product summary
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company name :
R&D Systems
product type :
antibody
product name :
CXCL1/GRO alpha/KC/CINC-1 Antibody
catalog :
MAB453-100
quantity :
100 ug
price :
431 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
48415
reactivity :
human
application :
western blot, ELISA, neutralization
more info or order :
citations: 46
Reference
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Seifert L, Werba G, Tiwari S, Giao Ly N, Alothman S, Alqunaibit D, et al. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature. 2016;532:245-9 pubmed publisher
Denney L, Byrne A, Shea T, Buckley J, Pease J, Herledan G, et al. Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function. Immunity. 2015;43:945-58 pubmed publisher
Lochhead R, Ma Y, Zachary J, Baltimore D, Zhao J, Weis J, et al. MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. PLoS Pathog. 2014;10:e1004212 pubmed publisher
West D, Del Rosso C, Yin X, Stuart P. CXCL1 but not IL-6 is required for recurrent herpetic stromal keratitis. J Immunol. 2014;192:1762-7 pubmed publisher
Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, et al. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol. 2013;190:5329-36 pubmed publisher
Junkins R, MacNeil A, Wu Z, McCormick C, Lin T. Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. J Immunol. 2013;190:5178-86 pubmed publisher
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Roy M, Richard J, Dumas A, Vallières L. CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis. J Neuroinflammation. 2012;9:18 pubmed publisher
Cheung R, Shen F, Phillips J, McGeachy M, Cua D, Heyworth P, et al. Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. J Clin Invest. 2011;121:4446-61 pubmed publisher
Kim J, Natarajan S, Vaickus L, Bouchard J, Beal D, Cruikshank W, et al. Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am J Pathol. 2011;179:2730-9 pubmed publisher
Summers S, van der Veen B, O Sullivan K, Gan P, Ooi J, Heeringa P, et al. Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney Int. 2010;78:1263-74 pubmed publisher
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Lemos H, Grespan R, Vieira S, Cunha T, Verri W, Fernandes K, et al. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A. 2009;106:5954-9 pubmed publisher
Wieland C, van der Windt G, Florquin S, McKenzie A, van der Poll T. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect. 2009;11:524-30 pubmed publisher
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Ramos C, Fernandes K, Canetti C, Teixeira M, Silva J, Cunha F. Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1alpha, TNF-alpha and LTB(4). Eur J Immunol. 2006;36:2025-34 pubmed
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Gao H, Hoesel L, Guo R, Rancilio N, Sarma J, Ward P. Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J Immunol. 2006;177:612-20 pubmed
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Guo R, Lentsch A, Warner R, Huber Lang M, Sarma J, Hlaing T, et al. Regulatory effects of eotaxin on acute lung inflammatory injury. J Immunol. 2001;166:5208-18 pubmed
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image
image 1 :
R&D Systems MAB453-100 image 1
Chemotaxis Induced by CXCL1/GROa/KC/CINC-1 and Neutralization by Mouse CXCL1/GROa/KC/CINC-1 Antibody.
product information
brand :
R&D Systems
master code :
MAB453
SKU :
MAB453-100
product name :
CXCL1/GRO alpha/KC/CINC-1 Antibody
unit size :
100 ug
description :
The Mouse CXCL1/GRO alpha/KC/CINC-1 Antibody from R&D Systems is a rat monoclonal antibody to CXCL1/GRO alpha/KC/CINC-1. This antibody reacts with mouse. The Mouse CXCL1/GRO alpha/KC/CINC-1 Antibody has been validated for the following applications: Western Blot, Neutralization.
target :
CXCL1/GRO alpha/KC/CINC-1
category :
Primary Antibodies
alt names :
CINC1, CINC-1, FSP, GRO alpha, GRO1, GROa, KC, MGSA, MGSA-a, MGSA-alpha, NAP-3, SCYB1
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
48415
conjugate :
Unconjugated
all available conjugate :
Unconjugated
host :
Rat
immunogen :
E. coli -derived recombinant mouse CXCL1/GRO alpha/KC/CINC-1, Arg20-Lys96, Accession # P12850
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Mouse
specificity :
Detects mouse CXCL1/GRO alpha/KC/CINC-1 in direct ELISAs and Western blots
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
gene symbol :
Cxcl1
endotoxin note :
<0.10 EU per 1 µg of the antibody by the LAL method.
accessionNumbers :
P12850
applications :
Western Blot, Neutralization, ELISA Capture (Matched Antibody Pair)
USD :
399
Jul-22 :
431 USD
sizes available :
100 ug (also 25 ug, 500 ug)
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.