product summary
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company name :
R&D Systems
product type :
antibody
product name :
Myosin Heavy Chain Antibody
catalog :
MAB4470
quantity :
100 ug
price :
421 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MF20
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
citations: 71
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:250; loading ...; fig 3a
Li Y, Zhang Y, Hu Q, Egranov S, Xing Z, Zhang Z, et al. Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects. Genome Med. 2021;13:137 pubmed publisher
Liu X, Zu E, Chang X, Ma X, Wang Z, Song X, et al. Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration. Dis Model Mech. 2021;14: pubmed publisher
Zhou M, Li B, Liu C, Hu M, Tang J, Min J, et al. M2 Macrophage-derived exosomal miR-501 contributes to pubococcygeal muscle regeneration. Int Immunopharmacol. 2021;101:108223 pubmed publisher
Park S, Jeong J, Oh S, Kim S, Kim H, Choi A, et al. Wharton's Jelly-Derived Mesenchymal Stem Cells Reduce Fibrosis in a Mouse Model of Duchenne Muscular Dystrophy by Upregulating microRNA 499. Biomedicines. 2021;9: pubmed publisher
Tan G, Kondo T, Imamura K, Suga M, Enami T, Nagahashi A, et al. Simple derivation of skeletal muscle from human pluripotent stem cells using temperature-sensitive Sendai virus vector. J Cell Mol Med. 2021;25:9586-9596 pubmed publisher
Ichimura E, Ojima K, Muroya S, Suzuki T, Kobayashi K, Nishimura T. The ubiquitin ligase Ozz decreases the replacement rate of embryonic myosin in myofibrils. Physiol Rep. 2021;9:e15003 pubmed publisher
Mennen R, Hallmark N, Pallardy M, Bars R, Tinwell H, Piersma A. Molecular neural crest cell markers enable discrimination of organophosphates in the murine cardiac embryonic stem cell test. Toxicol Rep. 2021;8:1513-1520 pubmed publisher
Lee B, Lee S, Lee Y, Park Y, Shim J. Emerin Represses STAT3 Signaling through Nuclear Membrane-Based Spatial Control. Int J Mol Sci. 2021;22: pubmed publisher
Niu M, Li L, Su Z, Wei L, Pu W, Zhao C, et al. An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models. Cell Death Dis. 2021;12:652 pubmed publisher
Yoshioka K, Nagahisa H, Miura F, Araki H, Kamei Y, Kitajima Y, et al. Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle. Sci Adv. 2021;7: pubmed publisher
Moustogiannis A, Philippou A, Taso O, Zevolis E, Pappa M, Chatzigeorgiou A, et al. The Effects of Muscle Cell Aging on Myogenesis. Int J Mol Sci. 2021;22: pubmed publisher
Knyazeva A, Khudiakov A, Vaz R, Muravyev A, Sukhareva K, Sejersen T, et al. FLNC Expression Level Influences the Activity of TEAD-YAP/TAZ Signaling. Genes (Basel). 2020;11: pubmed publisher
Shirakawa T, Miyawaki A, Matsubara T, Okumura N, Okamoto H, Nakai N, et al. Daily Oral Administration of Protease-Treated Royal Jelly Protects Against Denervation-Induced Skeletal Muscle Atrophy. Nutrients. 2020;12: pubmed publisher
Steil A, Kailing J, Armstrong C, Walgenbach D, Klein J. The calmodulin redox sensor controls myogenesis. PLoS ONE. 2020;15:e0239047 pubmed publisher
Ignatieva E, Ivanova O, Komarova M, Khromova N, Polev D, Kostareva A, et al. LMNA Mutations G232E and R482L Cause Dysregulation of Skeletal Muscle Differentiation, Bioenergetics, and Metabolic Gene Expression Profile. Genes (Basel). 2020;11: pubmed publisher
Lee J, Sutani A, Kaneko R, Takeuchi J, Sasano T, Kohda T, et al. In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix. Nat Commun. 2020;11:4283 pubmed publisher
Nakatake Y, Ko S, Sharov A, Wakabayashi S, Murakami M, Sakota M, et al. Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors. Cell Rep. 2020;31:107655 pubmed publisher
Xia B, Shi X, Xie B, Zhu M, Chen Y, Chu X, et al. Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice. PLoS Biol. 2020;18:e3000688 pubmed publisher
Lee S, Yang J, Park J, Shin H, Kim W, Kim S, et al. The MicroRNA-92a/Sp1/MyoD Axis Regulates Hypoxic Stimulation of Myogenic Lineage Differentiation in Mouse Embryonic Stem Cells. Mol Ther. 2020;28:142-156 pubmed publisher
Morisaka H, Yoshimi K, Okuzaki Y, Gee P, Kunihiro Y, Sonpho E, et al. CRISPR-Cas3 induces broad and unidirectional genome editing in human cells. Nat Commun. 2019;10:5302 pubmed publisher
Codato R, Perichon M, Divol A, Fung E, Sotiropoulos A, Bigot A, et al. The SMYD3 methyltransferase promotes myogenesis by activating the myogenin regulatory network. Sci Rep. 2019;9:17298 pubmed publisher
Nihashi Y, Umezawa K, Shinji S, Hamaguchi Y, Kobayashi H, Kono T, et al. Distinct cell proliferation, myogenic differentiation, and gene expression in skeletal muscle myoblasts of layer and broiler chickens. Sci Rep. 2019;9:16527 pubmed publisher
Huang Z, Fang Q, Ma W, Zhang Q, Qiu J, Gu X, et al. Skeletal Muscle Atrophy Was Alleviated by Salidroside Through Suppressing Oxidative Stress and Inflammation During Denervation. Front Pharmacol. 2019;10:997 pubmed publisher
Picchiarelli G, Demestre M, Zuko A, Been M, Higelin J, Dieterlé S, et al. FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis. Nat Neurosci. 2019;22:1793-1805 pubmed publisher
Lei S, She Y, Zeng J, Chen R, Zhou S, Shi H. Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo. Mol Med Rep. 2019;20:4175-4185 pubmed publisher
Zhang Y, Liu Y, Bi X, Hu C, Ding F, Ding W. Therapeutic Approaches in Mitochondrial Dysfunction, Inflammation, and Autophagy in Uremic Cachexia: Role of Aerobic Exercise. Mediators Inflamm. 2019;2019:2789014 pubmed publisher
Zhang Z, Zhang L, Zhou Y, Li L, Zhao J, Qin W, et al. Increase in HDAC9 suppresses myoblast differentiation via epigenetic regulation of autophagy in hypoxia. Cell Death Dis. 2019;10:552 pubmed publisher
Komatsu Y, Takeuchi D, Tokunaga T, Sakurai H, Makino A, Honda T, et al. RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs. Mol Ther Methods Clin Dev. 2019;14:47-55 pubmed publisher
Abbadi D, Yang M, Chenette D, Andrews J, Schneider R. Muscle development and regeneration controlled by AUF1-mediated stage-specific degradation of fate-determining checkpoint mRNAs. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Liu D, Qiao X, Ge Z, Shang Y, Li Y, Wang W, et al. IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway. Skelet Muscle. 2019;9:8 pubmed publisher
Fiedler L, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush P, et al. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019;24:579-591.e12 pubmed publisher
Bhat A, Palanichamy Kala M, Rao V, Pignata L, Lim H, Suriyamurthy S, et al. Epigenetic Regulation of the PTEN-AKT-RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma. Cancer Res. 2019;79:2232-2243 pubmed publisher
Ooi J, Langley S, Xu X, Utami K, Sim B, Huang Y, et al. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects. Cell Rep. 2019;26:2494-2508.e7 pubmed publisher
Estañ M, Fernández Núñez E, Zaki M, Esteban M, Donkervoort S, Hawkins C, et al. Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy. Nat Commun. 2019;10:797 pubmed publisher
Dmitrieva R, Lelyavina T, Komarova M, Galenko V, Ivanova O, Tikanova P, et al. Skeletal Muscle Resident Progenitor Cells Coexpress Mesenchymal and Myogenic Markers and Are Not Affected by Chronic Heart Failure-Induced Dysregulations. Stem Cells Int. 2019;2019:5690345 pubmed publisher
Sin T, Zhu J, Zhang G, Li Y. p300 Mediates Muscle Wasting in Lewis Lung Carcinoma. Cancer Res. 2019;79:1331-1342 pubmed publisher
Ling M, Quan L, Lai X, Lang L, Li F, Yang X, et al. VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway. Int J Mol Sci. 2021;22: pubmed publisher
Coleman M, Liu K, Pfeil A, Etigunta S, Tang X, Fabela S, et al. β-Hydroxy-β-Methylbutyrate Supplementation Promotes Antitumor Immunity in an Obesity Responsive Mouse Model of Pancreatic Ductal Adenocarcinoma. Cancers (Basel). 2021;13: pubmed publisher
Mennen R, Hallmark N, Pallardy M, Bars R, Tinwell H, Piersma A. Gene regulation by morpholines and piperidines in the cardiac embryonic stem cell test. Toxicol Appl Pharmacol. 2021;433:115781 pubmed publisher
Xu L, Zhang M, Shi L, Yang X, Chen L, Cao N, et al. Neural stemness contributes to cell tumorigenicity. Cell Biosci. 2021;11:21 pubmed publisher
Xiang X, Langlois S, St Pierre M, Barré J, Grynspan D, Purgina B, et al. Pannexin 1 inhibits rhabdomyosarcoma progression through a mechanism independent of its canonical channel function. Oncogenesis. 2018;7:89 pubmed publisher
Osaki T, Uzel S, Kamm R. Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons. Sci Adv. 2018;4:eaat5847 pubmed publisher
Sakane H, Akasaki K. The Major Lysosomal Membrane Proteins LAMP-1 and LAMP-2 Participate in Differentiation of C2C12 Myoblasts. Biol Pharm Bull. 2018;41:1186-1193 pubmed publisher
Sasaki T, Kuboyama A, Mita M, Murata S, Shimizu M, Inoue J, et al. The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice. J Biol Chem. 2018;293:10322-10332 pubmed publisher
Sakai Takemura F, Narita A, Masuda S, Wakamatsu T, Watanabe N, Nishiyama T, et al. Premyogenic progenitors derived from human pluripotent stem cells expand in floating culture and differentiate into transplantable myogenic progenitors. Sci Rep. 2018;8:6555 pubmed publisher
Yang R, Yang X, Liu S, Ming L, Zhou Z, Liang Y, et al. Activation of the Wnt/ β-catenin pathway by an inflammatory microenvironment affects the myogenic differentiation capacity of human laryngeal mucosa mesenchymal stromal cells. Stem Cells Dev. 2018;: pubmed publisher
Ojima K, Ichimura E, Suzuki T, Oe M, Muroya S, Nishimura T. HSP90 modulates the myosin replacement rate in myofibrils. Am J Physiol Cell Physiol. 2018;315:C104-C114 pubmed publisher
Kalbe B, Osterloh M, Schulz V, Altmuller J, Becker C, Osterloh S, et al. OR2H2 regulates the differentiation of human myoblast cells by its ligand aldehyde 13-13. Arch Biochem Biophys. 2018;645:72-80 pubmed publisher
Chen R, Xu J, She Y, Jiang T, Zhou S, Shi H, et al. Necrostatin-1 protects C2C12 myotubes from CoCl2-induced hypoxia. Int J Mol Med. 2018;41:2565-2572 pubmed publisher
Wattin M, Gaweda L, Muller P, Baritaud M, Scholtes C, Lozano C, et al. Modulation of Protein Quality Control and Proteasome to Autophagy Switch in Immortalized Myoblasts from Duchenne Muscular Dystrophy Patients. Int J Mol Sci. 2018;19: pubmed publisher
Koide M, Hagiwara Y, Tsuchiya M, Kanzaki M, Hatakeyama H, Tanaka Y, et al. Retained Myogenic Potency of Human Satellite Cells from Torn Rotator Cuff Muscles Despite Fatty Infiltration. Tohoku J Exp Med. 2018;244:15-24 pubmed publisher
Lee H, Lee S, Bae G, Baek N, Ryu J. Canadine from Corydalis turtschaninovii Stimulates Myoblast Differentiation and Protects against Myotube Atrophy. Int J Mol Sci. 2017;18: pubmed publisher
Zhang G, Liu Z, Ding H, Zhou Y, Doan H, Sin K, et al. Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90. Nat Commun. 2017;8:589 pubmed publisher
Cleary M, Mansoor A, Settelmeyer T, Ijiri Y, Ladner K, Svalina M, et al. NF?B signaling in alveolar rhabdomyosarcoma. Dis Model Mech. 2017;10:1109-1115 pubmed publisher
Kokabu S, Nakatomi C, Matsubara T, Ono Y, Addison W, Lowery J, et al. The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor. J Biol Chem. 2017;292:12885-12894 pubmed publisher
Han D, Yang W, Kao T. Dexamethasone Treatment at the Myoblast Stage Enhanced C2C12 Myocyte Differentiation. Int J Med Sci. 2017;14:434-443 pubmed publisher
Lacour F, Vezin E, Bentzinger C, Sincennes M, Giordani L, Ferry A, et al. R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways. Cell Rep. 2017;18:2320-2330 pubmed publisher
Ueki J, Nakamori M, Nakamura M, Nishikawa M, Yoshida Y, Tanaka A, et al. Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability. Sci Rep. 2017;7:42522 pubmed publisher
Phelps M, Bailey J, Vleeshouwer Neumann T, Chen E. CRISPR screen identifies the NCOR/HDAC3 complex as a major suppressor of differentiation in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016;113:15090-15095 pubmed publisher
Ding H, Zhang G, Sin K, Liu Z, Lin R, Li M, et al. Activin A induces skeletal muscle catabolism via p38? mitogen-activated protein kinase. J Cachexia Sarcopenia Muscle. 2017;8:202-212 pubmed publisher
Arai S, Ikeda M, Ide T, Matsuo Y, Fujino T, Hirano K, et al. Functional loss of DHRS7C induces intracellular Ca2+ overload and myotube enlargement in C2C12 cells via calpain activation. Am J Physiol Cell Physiol. 2017;312:C29-C39 pubmed publisher
Enoki Y, Watanabe H, Arake R, Sugimoto R, Imafuku T, Tominaga Y, et al. Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1. Sci Rep. 2016;6:32084 pubmed publisher
Choi J, Kang S, Kim Y, Park J, Yang S, Kim Y, et al. Novel Therapeutic Effects of Non-thermal atmospheric pressure plasma for Muscle Regeneration and Differentiation. Sci Rep. 2016;6:28829 pubmed publisher
Kim A, Im M, Gu M, Ma J. Citrus unshiu peel extract alleviates cancer-induced weight loss in mice bearing CT-26 adenocarcinoma. Sci Rep. 2016;6:24214 pubmed publisher
Vleeshouwer Neumann T, Phelps M, Bammler T, MacDonald J, Jenkins I, Chen E. Histone Deacetylase Inhibitors Antagonize Distinct Pathways to Suppress Tumorigenesis of Embryonal Rhabdomyosarcoma. PLoS ONE. 2015;10:e0144320 pubmed publisher
Boyle K, Patinkin Z, Shapiro A, Baker P, Dabelea D, Friedman J. Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project. Diabetes. 2016;65:647-59 pubmed publisher
Li V, Kirschner M. Molecular ties between the cell cycle and differentiation in embryonic stem cells. Proc Natl Acad Sci U S A. 2014;111:9503-8 pubmed publisher
Yaden B, Wang Y, Wilson J, Culver A, Milner A, Datta Mannan A, et al. Inhibition of activin A ameliorates skeletal muscle injury and rescues contractile properties by inducing efficient remodeling in female mice. Am J Pathol. 2014;184:1152-66 pubmed publisher
Goudenege S, LeBel C, Huot N, Dufour C, Fujii I, Gekas J, et al. Myoblasts derived from normal hESCs and dystrophic hiPSCs efficiently fuse with existing muscle fibers following transplantation. Mol Ther. 2012;20:2153-67 pubmed publisher
Joe M, Kee C, Tomarev S. Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex. J Biol Chem. 2012;287:13216-27 pubmed publisher
Ono Y, Masuda S, Nam H, Benezra R, Miyagoe Suzuki Y, Takeda S. Slow-dividing satellite cells retain long-term self-renewal ability in adult muscle. J Cell Sci. 2012;125:1309-17 pubmed publisher
image
image 1 :
R&D Systems MAB4470 image 1
Myosin Heavy Chain antibody in C2C12 Mouse Cell Line by Immunocytochemistry (ICC).
product information
brand :
R&D Systems
master code :
MAB4470
SKU :
MAB4470
product name :
Myosin Heavy Chain Antibody
unit size :
100 ug
description :
The Neuropeptide Y Recombinant Protein Antigen from Novus Biologicals is derived from E. coli. The Neuropeptide Y Recombinant Protein Antigen has been validated for the following applications: Antibody Competition.
target :
Myosin Heavy Chain
category :
Primary Antibodies
alt names :
DFNA4, FLJ13881, FLJ43092, KIAA2034DKFZp667A1311, MHC16, MYH14 variant protein, MYH17, MYHC, myosin, Myosin heavy chain 14, Myosin heavy chain, non-muscle IIc, myosin, heavy chain 14, myosin, heavy chain 14, non-muscle, myosin, heavy polypeptide 14, myosin-14, NMHC II-C, NMHC-II-C, nonmuscle myosin heavy chain II-C, Non-muscle myosin heavy chain IIc
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
MF20
concentration :
LYOPH
conjugate :
Unconjugated
all available conjugate :
Alexa Fluor 700
host :
Mouse
immunogen :
Chicken pectoralis-derived Myosin
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Multi-Species
specificity :
Detects Myosin Heavy Chain in human, mouse, rat and other mammalian, avian, and amphibian species
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
gene symbol :
MYH14
applications :
Western Blot, Immunohistochemistry, Immunocytochemistry
USD :
389
Jul-22 :
421 USD
sizes available :
100 ug (also 25 ug)
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.