product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human PTPN14 Antibody
catalog :
MAB4458
quantity :
100 ug (also 25 ug)
price :
439 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
448701
reactivity :
human
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 9
Reference
Wang L, Proulx M, Kim A, Lelarge V, McCaffrey L. A proximity proteomics screen in three-dimensional spheroid cultures identifies novel regulators of lumen formation. Sci Rep. 2021;11:22807 pubmed publisher
Díaz Valdivia N, Diaz J, Contreras P, Campos A, Rojas Celis V, Burgos Ravanal R, et al. The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis. Oncogene. 2020;39:3693-3709 pubmed publisher
Szelachowska J, Donizy P, Ratajczak Wielgomas K, Halon A, Zielecka Debska D, Lichon K, et al. The effect of YAP expression in tumor cells and tumor stroma on the prognosis of patients with squamous cell carcinoma of the oral cavity floor and oral surface of the tongue. Oncol Lett. 2019;18:3561-3570 pubmed publisher
Fearnley G, Young K, Edgar J, Antrobus R, Hay I, Liang W, et al. The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion. elife. 2019;8: pubmed publisher
Fan G, Aleem S, Yang M, Miller W, Tonks N. Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase. J Biol Chem. 2015;290:15934-47 pubmed publisher
Ramesh M, Krishnan N, Muthuswamy S, Tonks N. A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. J Biol Chem. 2015;290:9646-59 pubmed publisher
Fan G, Lin G, Lucito R, Tonks N. Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells. J Biol Chem. 2013;288:24923-34 pubmed publisher
Michaloglou C, Lehmann W, Martin T, Delaunay C, Hueber A, Barys L, et al. The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity. PLoS ONE. 2013;8:e61916 pubmed publisher
Huang J, Nagatomo I, Suzuki E, Mizuno T, Kumagai T, Berezov A, et al. YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14. Oncogene. 2013;32:2220-9 pubmed publisher
product information
master code :
MAB4458
SKU :
MAB4458
product name :
Human PTPN14 Antibody
unit size :
100 ug (also 25 ug)
description :
The Human PTPN14 Antibody from R&D Systems is a mouse monoclonal antibody to PTPN14/PTPD2. This antibody reacts with human. The Human PTPN14 Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin.
target :
PTPN14
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
448701
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant human PTPN14, Leu329-Leu900, Accession # Q15678.2
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects endogenous human PTPN14 in Western blots. In Western blots, this antibody does not cross-react with recombinant human (rh) PTPN13 or rhPTPN22.
gene symbol :
PTPN14
top caption :
Detection of Human PTPN14 antibody by Western Blot.
accessionNumbers :
Q15678.2
applications :
Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin
USD :
439 USD
alt names :
EC 3.1.3, EC 3.1.3.48, MGC126803, PEZ, PEZcytoskeletal-associated protein tyrosine phosphatase, protein tyrosine phosphatase, non-receptor type 14, Protein-tyrosine phosphatase pez, PTP36, tyrosine-protein phosphatase non-receptor type 14
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.