Human Lysine Hydroxylase 2/PLOD2 Antibody | R&D Systems MAB4445 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Lysine Hydroxylase 2/PLOD2 Antibody

catalog :

MAB4445

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

408105

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 6

Reference
Liu Q, Liu N, van der Noord V, van der Stel W, van de Water B, Danen E, et al. Differential response of luminal and basal breast cancer cells to acute and chronic hypoxia. Breast Cancer Res Treat. 2023;198:583-596 pubmed publisher
Brereton C, Yao L, Davies E, Zhou Y, Vukmirovic M, Bell J, et al. Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis. elife. 2022;11: pubmed publisher
Gjaltema R, Goubert D, Huisman C, Pilar García Tobilla C, Koncz M, Jellema P, et al. KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation. Int J Mol Sci. 2020;21: pubmed publisher
Greenhough A, Bagley C, Heesom K, Gurevich D, Gay D, Bond M, et al. Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. EMBO Mol Med. 2018;10: pubmed publisher
Chen Y, Guo H, Terajima M, Banerjee P, Liu X, Yu J, et al. Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space. J Biol Chem. 2016;291:25799-25808 pubmed
Chen Y, Terajima M, Yang Y, Sun L, Ahn Y, Panková D, et al. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest. 2015;125:1147-62 pubmed publisher

product information

master code :

MAB4445

SKU :

MAB4445

product name :

Human Lysine Hydroxylase 2/PLOD2 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Lysine Hydroxylase 2/PLOD2 Antibody from R&D Systems is a mouse monoclonal antibody to Lysine Hydroxylase 2/PLOD2. This antibody reacts with human,mouse. The Human Lysine Hydroxylase 2/PLOD2 Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Paraffin.

target :

Lysine Hydroxylase 2/PLOD2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

408105

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Lysine Hydroxylase 2/PLOD2, Ala26-Pro758, Accession # NP_891988

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human Lysine Hydroxylase 2/PLOD2 in direct ELISAs and Western blots.

gene symbol :

PLOD2

accessionNumbers :

NP_891988

applications :

Western Blot,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Paraffin

USD :

479 USD

alt names :

2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2, 2-oxoglutarate 5-dioxygenase 2, LH2, PLOD2, procollagen-lysine, telopeptide lysyl hydroxylase, TLH

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage