Mouse CD40/TNFRSF5 Antibody | R&D Systems MAB440-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse CD40/TNFRSF5 Antibody

catalog :

MAB440-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

1C10

reactivity :

human, mouse

application :

neutralization, immunoprecipitation, flow cytometry

more info or order :

R&D Systems product webpage

citations: 10

Reference
Ortega Molina A, Lebrero Fernández C, Sanz A, Deleyto Seldas N, Plata Gómez A, Menéndez C, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021;36:109372 pubmed publisher
Tivadar S, McIntosh R, Chua J, Moss R, Parsons T, Zaitoun A, et al. Monoclonal Antibody Targeting Sialyl-di-Lewisa-Containing Internalizing and Noninternalizing Glycoproteins with Cancer Immunotherapy Development Potential. Mol Cancer Ther. 2020;19:790-801 pubmed publisher
Ortega Molina A, Deleyto Seldas N, Carreras J, Sanz A, Lebrero Fernández C, Menéndez C, et al. Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR. Nat Metab. 2019;1:775-789 pubmed publisher
Obmolova G, Teplyakov A, Malia T, Wunderler N, Kwok D, Barone L, et al. Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography. Mol Immunol. 2017;83:92-99 pubmed publisher
Santulli Marotto S, Gervais A, Fisher J, Strake B, Ogden C, Riveley C, et al. Discovering Molecules That Regulate Efferocytosis Using Primary Human Macrophages and High Content Imaging. PLoS ONE. 2015;10:e0145078 pubmed publisher
Pierson E, Stromnes I, GOVERMAN J. B cells promote induction of experimental autoimmune encephalomyelitis by facilitating reactivation of T cells in the central nervous system. J Immunol. 2014;192:929-39 pubmed publisher
Hock M, Vaeth M, Rudolf R, Patra A, Pham D, Muhammad K, et al. NFATc1 induction in peripheral T and B lymphocytes. J Immunol. 2013;190:2345-53 pubmed publisher
Lechouane F, Bonaud A, Delpy L, Casola S, Oruc Z, Chemin G, et al. B-cell receptor signal strength influences terminal differentiation. Eur J Immunol. 2013;43:619-28 pubmed publisher
Liu J, Yoshida Y, Yamashita U. Suppressive effect of reactive oxygen species on CD40-induced B cell activation. FEBS Lett. 2007;581:5043-9 pubmed
de la Fuente M, Kumar L, Lu B, Geha R. 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol Cell Biol. 2006;26:5214-25 pubmed

product information

master code :

MAB440

SKU :

MAB440-100

product name :

Mouse CD40/TNFRSF5 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Mouse CD40/TNFRSF5 Antibody from R&D Systems is a rat monoclonal antibody to CD40/TNFRSF5. This antibody reacts with mouse,transgenic mouse. The Mouse CD40/TNFRSF5 Antibody has been validated for the following applications: Neutralization,Functional Assay,Bioassay,Flow Cytometry,In vivo assay,Immunoprecipitation,Agonist Activity,CyTOF-ready.

target :

CD40/TNFRSF5

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

1C10

conjugate :

Unconjugated

host :

Rat

immunogen :

COS-7 African green monkey SV40 transformed kidney fibroblast-like cell line-derived recombinant mouse CD40/TNFRSF5, Extracellular domain

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse

specificity :

Specifically binds mouse CD40/TNFRSF5 expressed on B cells.

gene symbol :

CD40

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

applications :

Bioassay,Flow Cytometry,Neutralization,Functional Assay,In vivo assay,Immunoprecipitation,Agonist Activity,CyTOF-ready

USD :

479 USD

alt names :

B cell surface antigen CD40, B-cell surface antigen CD40, Bp50B cell-associated molecule, CD40, CD40 antigen, CD40 molecule, TNF receptor superfamily member 5, CD40 type II isoform, CD40L receptor, CDw40, MGC9013, nerve growth factor receptor-related B-lymphocyte activation molecule, p50, TNFRSF5, TNFRSF5CD40 antigen (TNF receptor superfamily member 5), tumor necrosis factor receptor superfamily member 5, tumor necrosis factor receptor superfamily, member 5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage