product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human CXCR7/RDC-1 Antibody
catalog :
MAB42273
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
11G8
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 36
Reference
Hamshaw I, Ellahouny Y, Malusickis A, Newman L, Ortiz Jacobs D, Mueller A. The role of PKC and PKD in CXCL12 and CXCL13 directed malignant melanoma and acute monocytic leukemic cancer cell migration. Cell Signal. 2024;113:110966 pubmed publisher
D Alterio C, Giardino A, Scognamiglio G, Butturini G, Portella L, Guardascione G, et al. CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients. Cells. 2022;11: pubmed publisher
Hopkins B, Masuho I, Ren D, Iyamu I, Lv W, Malik N, et al. Effects of Small Molecule Ligands on ACKR3 Receptors. Mol Pharmacol. 2022;102:128-138 pubmed publisher
D Alterio C, Spina A, Arenare L, Chiodini P, Napolitano M, Galdiero F, et al. Biological Role of Tumor/Stromal CXCR4-CXCL12-CXCR7 in MITO16A/MaNGO-OV2 Advanced Ovarian Cancer Patients. Cancers (Basel). 2022;14: pubmed publisher
Mause S, Ritzel E, Deck A, Vogt F, Liehn E. Engagement of the CXCL12-CXCR4 Axis in the Interaction of Endothelial Progenitor Cell and Smooth Muscle Cell to Promote Phenotype Control and Guard Vascular Homeostasis. Int J Mol Sci. 2022;23: pubmed publisher
Meyrath M, Szpakowska M, Zeiner J, Massotte L, Merz M, Benkel T, et al. The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides. Nat Commun. 2020;11:3033 pubmed publisher
Wei S, Huang Y, Hsieh M, Lin Y, Shyu W, Chen H, et al. Atypical chemokine receptor ACKR3/CXCR7 controls postnatal vasculogenesis and arterial specification by mesenchymal stem cells via Notch signaling. Cell Death Dis. 2020;11:307 pubmed publisher
Pluchino N, Mamillapalli R, Shaikh S, Habata S, Tal A, Gaye M, et al. CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking. J Cell Mol Med. 2020;24:2464-2474 pubmed publisher
Ierano C, D Alterio C, Giarra S, Napolitano M, Rea G, Portella L, et al. CXCL12 loaded-dermal filler captures CXCR4 expressing melanoma circulating tumor cells. Cell Death Dis. 2019;10:562 pubmed publisher
Syu G, Wang S, Ma G, Liu S, Pearce D, Prakash A, et al. Development and application of a high-content virion display human GPCR array. Nat Commun. 2019;10:1997 pubmed publisher
Li S, Fong K, Gritsina G, Zhang A, Zhao J, Kim J, et al. Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer. Cancer Res. 2019;79:2580-2592 pubmed publisher
Xu S, Tang J, Wang C, Liu J, Fu Y, Luo Y. CXCR7 promotes melanoma tumorigenesis via Src kinase signaling. Cell Death Dis. 2019;10:191 pubmed publisher
Wang M, Yang X, Wei M, Wang Z. The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer. J Cancer. 2018;9:3898-3903 pubmed publisher
Gao X, Abdelkarim H, Albee L, Volkman B, Gaponenko V, Majetschak M. Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3. PLoS ONE. 2018;13:e0204041 pubmed publisher
Willems E, Dedobbeleer M, Digregorio M, Lombard A, Goffart N, Lumapat P, et al. Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration. Oncogene. 2019;38:73-87 pubmed publisher
Kaur G, Helmer R, Smith L, Martinez Zaguilan R, Dufour J, Chilton B. Alternative splicing of helicase-like transcription factor (Hltf): Intron retention-dependent activation of immune tolerance at the feto-maternal interface. PLoS ONE. 2018;13:e0200211 pubmed publisher
Pluchino N, Mamillapalli R, Moridi I, Tal R, Taylor H. G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis. Reprod Sci. 2018;25:1168-1174 pubmed publisher
D huys T, Claes S, Van Loy T, Schols D. CXCR7/ACKR3-targeting ligands interfere with X7 HIV-1 and HIV-2 entry and replication in human host cells. Heliyon. 2018;4:e00557 pubmed publisher
Montpas N, St Onge G, Nama N, Rhainds D, Benredjem B, Girard M, et al. Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3-mediated chemokine scavenging. J Biol Chem. 2018;293:893-905 pubmed publisher
Cheng Y, Eby J, Laporte H, Volkman B, Majetschak M. Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function. PLoS ONE. 2017;12:e0187949 pubmed publisher
Zhang M, Qiu L, Zhang Y, Xu D, Zheng J, Jiang L. CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells. Sci Rep. 2017;7:8289 pubmed publisher
Hira V, Verbovšek U, Breznik B, Srdič M, Novinec M, Kakar H, et al. Cathepsin K cleavage of SDF-1? inhibits its chemotactic activity towards glioblastoma stem-like cells. Biochim Biophys Acta Mol Cell Res. 2017;1864:594-603 pubmed publisher
Evans A, Tripathi A, Laporte H, Brueggemann L, Singh A, Albee L, et al. New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle. Int J Mol Sci. 2016;17: pubmed publisher
Flüh C, Hattermann K, Mehdorn H, Synowitz M, Held Feindt J. Differential expression of CXCR4 and CXCR7 with various stem cell markers in paired human primary and recurrent glioblastomas. Int J Oncol. 2016;48:1408-16 pubmed publisher
Tripathi A, Gaponenko V, Majetschak M. Commercially available antibodies directed against α-adrenergic receptor subtypes and other G protein-coupled receptors with acceptable selectivity in flow cytometry experiments. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:243-8 pubmed publisher
Mühlethaler Mottet A, Liberman J, Ascenção K, Flahaut M, Balmas Bourloud K, Yan P, et al. The CXCR4/CXCR7/CXCL12 Axis Is Involved in a Secondary but Complex Control of Neuroblastoma Metastatic Cell Homing. PLoS ONE. 2015;10:e0125616 pubmed publisher
Wester H, Keller U, Schottelius M, Beer A, Philipp Abbrederis K, Hoffmann F, et al. Disclosing the CXCR4 expression in lymphoproliferative diseases by targeted molecular imaging. Theranostics. 2015;5:618-30 pubmed publisher
Neve Polimeno M, Ierano C, D Alterio C, Simona Losito N, Napolitano M, Portella L, et al. CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not. Cell Mol Immunol. 2015;12:474-82 pubmed publisher
Walsh T, Harper M, Poole A. SDF-1α is a novel autocrine activator of platelets operating through its receptor CXCR4. Cell Signal. 2015;27:37-46 pubmed publisher
Liu Y, Carson Walter E, Walter K. Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells. PLoS ONE. 2014;9:e103938 pubmed publisher
Boudot A, Kerdivel G, Lecomte S, Flouriot G, Desille M, Godey F, et al. COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration. BMC Cancer. 2014;14:407 pubmed publisher
Walters M, Ebsworth K, Berahovich R, Penfold M, Liu S, Al Omran R, et al. Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats. Br J Cancer. 2014;110:1179-88 pubmed publisher
Ding B, Cao Z, Lis R, Nolan D, Guo P, Simons M, et al. Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature. 2014;505:97-102 pubmed publisher
Liberman J, Sartelet H, Flahaut M, Mühlethaler Mottet A, Coulon A, Nyalendo C, et al. Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma. PLoS ONE. 2012;7:e43665 pubmed publisher
Canals M, Scholten D, de Munnik S, Han M, Smit M, Leurs R. Ubiquitination of CXCR7 controls receptor trafficking. PLoS ONE. 2012;7:e34192 pubmed publisher
Naumann U, Cameroni E, Pruenster M, Mahabaleshwar H, Raz E, Zerwes H, et al. CXCR7 functions as a scavenger for CXCL12 and CXCL11. PLoS ONE. 2010;5:e9175 pubmed publisher
product information
brand :
R&D Systems
master code :
MAB42273
SKU :
MAB42273
product name :
Human CXCR7/RDC-1 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human CXCR7/RDC-1 Antibody from R&D Systems is a mouse monoclonal antibody to CXCR7/RDC-1. This antibody reacts with human,mouse,rat,transgenic mouse. The Human CXCR7/RDC-1 Antibody has been validated for the following applications: Immunohistochemistry,Immunocytochemistry,IHC-,Bioassay,Inhibition,Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,Functional Assay,Cell Selection,Immunohistochemistry-Paraffin,CyTOF-ready.
target :
CXCR7/RDC-1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
11G8
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 8-25 ug/mL, CyTOF-ready
host :
Mouse
immunogen :
Human CXCR7 encoding plasmid, Accession # P25106
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Rat
specificity :
Detects human CXCR7/RDC-1 in flow cytometry of five distinct human CXCR7 transfectants, but not their respective parental lines.
gene symbol :
CXCR7
top caption :
Detection of CXCR7/RDC-1 antibody in MCF-7 Human Cell Line antibody by Flow Cytometry.
accessionNumbers :
P25106
applications :
CyTOF-ready,Bioassay,Inhibition,IHC-,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry,Functional Assay,Cell Selection
USD :
499 USD
alt names :
ACKR3, chemokine (C-X-C motif) receptor 7, Chemokine orphan receptor 1CMKOR1C-X-C chemokine receptor type 7, CMKOR1, CXCR7, CXC-R7, CXCR-7, G protein-coupled receptor, GPR159, GPR159G-protein coupled receptor 159, RDC-1, RDC1G-protein coupled receptor RDC1 homolog
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.