Mouse GM-CSF Antibody | R&D Systems MAB415-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse GM-CSF Antibody

catalog :

MAB415-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

509 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MP122E9

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, neutralization

more info or order :

R&D Systems product webpage

citations: 17

Reference
Hillers Ziemer L, Williams A, Janquart A, Grogan C, Thompson V, Sánchez A, et al. Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis. Cancers (Basel). 2021;13: pubmed publisher
Iyer S, Zhang S, Yucel S, Horn H, Smith S, Reinhardt F, et al. Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy. Cancer Discov. 2021;11:384-407 pubmed publisher
Devette C, Gundlapalli H, Lai S, McMurtrey C, Hoover A, Gurung H, et al. A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer. Oncoimmunology. 2020;9:1685300 pubmed publisher
Braathen R, Spång H, Lindeberg M, Fossum E, Grødeland G, Fredriksen A, et al. The Magnitude and IgG Subclass of Antibodies Elicited by Targeted DNA Vaccines Are Influenced by Specificity for APC Surface Molecules. Immunohorizons. 2018;2:38-53 pubmed publisher
Yan J, Zhao Q, Gabrusiewicz K, Kong L, Xia X, Wang J, et al. FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nat Commun. 2019;10:448 pubmed publisher
Casanova Acebes M, Nicolás Ávila J, Li J, Garcia Silva S, Balachander A, Rubio Ponce A, et al. Neutrophils instruct homeostatic and pathological states in naive tissues. J Exp Med. 2018;215:2778-2795 pubmed publisher
McNamee E, Biette K, Hammer J, Harris R, Miyazawa H, Lee J, et al. Targeting granulocyte-macrophage colony-stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis. Allergy. 2017;72:1232-1242 pubmed publisher
Rothhammer V, Mascanfroni I, Bunse L, Takenaka M, Kenison J, Mayo L, et al. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med. 2016;22:586-97 pubmed publisher
Nata T, Basheer A, Cocchi F, van Besien R, Massoud R, Jacobson S, et al. Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum. J Biol Chem. 2015;290:22338-51 pubmed publisher
Tanabe N, Hoshino Y, Marumo S, Kiyokawa H, Sato S, Kinose D, et al. Thioredoxin-1 protects against neutrophilic inflammation and emphysema progression in a mouse model of chronic obstructive pulmonary disease exacerbation. PLoS ONE. 2013;8:e79016 pubmed publisher
Petrackova M, Staněk L, Mandys V, Dundr P, Vonka V. Properties of bcr-abl-transformed mouse 12B1 cells secreting interleukin-2 and granulocyte-macrophage colony stimulating factor (GM-CSF): II. Adverse effects of GM-CSF. Int J Oncol. 2012;40:1915-22 pubmed publisher
Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, et al. Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine. 2012;58:169-77 pubmed publisher
Cheung R, Shen F, Phillips J, McGeachy M, Cua D, Heyworth P, et al. Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. J Clin Invest. 2011;121:4446-61 pubmed publisher
Wengner A, Pitchford S, Furze R, Rankin S. The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood. 2008;111:42-9 pubmed
Dumas C, Muyombwe A, Roy G, Matte C, Ouellette M, Olivier M, et al. Recombinant Leishmania major secreting biologically active granulocyte-macrophage colony-stimulating factor survives poorly in macrophages in vitro and delays disease development in mice. Infect Immun. 2003;71:6499-509 pubmed
Pechová J, Stepánová G, Kovar L, Kopecky J. Tick salivary gland extract-activated transmission of Borrelia afzelii spirochaetes. Folia Parasitol (Praha). 2002;49:153-9 pubmed
Tomaki M, Zhao L, Sjöstrand M, Linden A, Ichinose M, Lotvall J. Comparison of effects of anti-IL-3, IL-5 and GM-CSF treatments on eosinophilopoiesis and airway eosinophilia induced by allergen. Pulm Pharmacol Ther. 2002;15:161-8 pubmed

product information

master code :

MAB415

SKU :

MAB415-100

product name :

Mouse GM-CSF Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Mouse GM-CSF Antibody from R&D Systems is a rat monoclonal antibody to GM-CSF. This antibody reacts with mouse,transgenic mouse. The Mouse GM-CSF Antibody has been validated for the following applications: Neutralization,ELISA Development,Luminex Development,In vivo assay,Immunocytochemistry,Western Blot,ELISA Capture (Matched Antibody Pair).

target :

GM-CSF

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

MP122E9

conjugate :

Unconjugated

host :

Rat

immunogen :

Yeast derived recombinant mouse GM-CSF, Accession # P01587

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse

specificity :

Detects mouse GM-CSF in ELISAs and Western blots. In Western blots, this antibody does not cross-react with recombinant human GM-CSF.

gene symbol :

CSF2

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Cell Proliferation Induced by GM-CSF and Neutralization by Mouse GM-CSF Antibody.

accessionNumbers :

P01587

applications :

ELISA Development,Luminex Development,Neutralization,In vivo assay,Immunocytochemistry,Western Blot,ELISA Capture (Matched Antibody Pair)

USD :

509 USD

alt names :

colony stimulating factor 2 (granulocyte-macrophage), Colony-stimulating factor, CSF, CSF2, CSF-2, GMCSF, GM-CSF, GMCSFgranulocyte-macrophage colony-stimulating factor, granulocyte-macrophage colony stimulating factor, MGC131935, MGC138897, Molgramostim, molgramostin, sargramostim

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage