G-CSF Antibody | R&D Systems MAB414-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

G-CSF Antibody

catalog :

MAB414-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

442 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

67604

reactivity :

mouse

application :

western blot, ELISA, neutralization

more info or order :

R&D Systems product webpage

citations: 35

Reference
Kwak D, Park D, Kim J. Leukotriene B4 Receptor 2 Mediates the Production of G-CSF That Plays a Critical Role in Steroid-Resistant Neutrophilic Airway Inflammation. Biomedicines. 2022;10: pubmed publisher
Goedhart M, Slot E, Pascutti M, Geerman S, Rademakers T, Nota B, et al. Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen. Cells. 2021;11: pubmed publisher
Yu H, Zhang T, Lu H, Ma Q, Zhao D, Sun J, et al. Granulocyte colony-stimulating factor (G-CSF) mediates bone resorption in periodontitis. BMC Oral Health. 2021;21:299 pubmed publisher
Umeshappa C, Solé P, Surewaard B, Yamanouchi J, Mohapatra S, Uddin M, et al. Liver-specific T regulatory type-1 cells program local neutrophils to suppress hepatic autoimmunity via CRAMP. Cell Rep. 2021;34:108919 pubmed publisher
Ouyang S, Liu C, Xiao J, Chen X, Lui A, Li X. Targeting IL-17A/glucocorticoid synergy to CSF3 expression in neutrophilic airway diseases. JCI Insight. 2020;5: pubmed publisher
Ubellacker J, Baryawno N, Severe N, Decristo M, Sceneay J, Hutchinson J, et al. Modulating Bone Marrow Hematopoietic Lineage Potential to Prevent Bone Metastasis in Breast Cancer. Cancer Res. 2018;78:5300-5314 pubmed publisher
Sparber F, Dolowschiak T, Mertens S, Lauener L, Clausen B, Joller N, et al. Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection. PLoS Pathog. 2018;14:e1007069 pubmed publisher
Meyer M, Baer J, Knolhoff B, Nywening T, Panni R, Su X, et al. Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance. Nat Commun. 2018;9:1250 pubmed publisher
Banuelos J, Cao Y, Shin S, Bochner B, Avila P, Li S, et al. Granulocyte colony-stimulating factor blockade enables dexamethasone to inhibit lipopolysaccharide-induced murine lung neutrophils. PLoS ONE. 2017;12:e0177884 pubmed publisher
Zhu H, Kwak H, Liu P, Bajrami B, Xu Y, Park S, et al. Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis. J Immunol. 2017;198:2854-2864 pubmed publisher
Campbell I, Leong D, Edwards K, Rayzman V, Ng M, Goldberg G, et al. Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis. J Immunol. 2016;197:4392-4402 pubmed
Moreau J, Mielnik M, Berger A, Furlonger C, Paige C. Tumor-secreted products repress B-cell lymphopoiesis in a murine model of breast cancer. Eur J Immunol. 2016;46:2835-2841 pubmed publisher
Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed publisher
Müller A, Dolowschiak T, Sellin M, Felmy B, Verbree C, Gadient S, et al. An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection. PLoS Pathog. 2016;12:e1005723 pubmed publisher
Bohannon J, Luan L, Hernandez A, Afzal A, Guo Y, Patil N, et al. Role of G-CSF in monophosphoryl lipid A-mediated augmentation of neutrophil functions after burn injury. J Leukoc Biol. 2016;99:629-40 pubmed publisher
Sivakumaran S, Henderson S, Ward S, Sousa P, Manzo T, Zhang L, et al. Depletion of CD11câº cells in the CD11c.DTR model drives expansion of unique CD64âº Ly6Câº monocytes that are poised to release TNF-Î±. Eur J Immunol. 2016;46:192-203 pubmed publisher
Cedervall J, Zhang Y, Huang H, Zhang L, Femel J, Dimberg A, et al. Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals. Cancer Res. 2015;75:2653-62 pubmed publisher
Agarwal S, Lakoma A, Chen Z, Hicks J, Metelitsa L, Kim E, et al. G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation. Cancer Res. 2015;75:2566-79 pubmed publisher
Coffelt S, Kersten K, Doornebal C, Weiden J, Vrijland K, Hau C, et al. IL-17-producing Î³Î´ T cells and neutrophils conspire to promote breast cancer metastasis. Nature. 2015;522:345-348 pubmed publisher
Brooks R, Iyer S, Akada H, Neelam S, Russo C, Chisholm J, et al. Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi. Stem Cells. 2015;33:848-58 pubmed publisher
Trautwein Weidner K, Gladiator A, Nur S, Diethelm P, LeibundGut Landmann S. IL-17-mediated antifungal defense in the oral mucosa is independent of neutrophils. Mucosal Immunol. 2015;8:221-31 pubmed publisher
Gardner J, Noel J, Nikolaidis N, Karns R, Aronow B, Ogle C, et al. G-CSF drives a posttraumatic immune program that protects the host from infection. J Immunol. 2014;192:2405-17 pubmed publisher
Taniguchi K, Arima K, Masuoka M, Ohta S, Shiraishi H, Ontsuka K, et al. Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1?/IL-6 loop. J Invest Dermatol. 2014;134:1295-1304 pubmed publisher
Kulkarni S, Singh P, Ghosh S, Posarac A, Singh V. Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure. Cytokine. 2013;62:278-85 pubmed publisher
Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, et al. Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine. 2012;58:169-77 pubmed publisher
Waight J, Hu Q, Miller A, Liu S, Abrams S. Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism. PLoS ONE. 2011;6:e27690 pubmed publisher
Cheung R, Shen F, Phillips J, McGeachy M, Cua D, Heyworth P, et al. Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. J Clin Invest. 2011;121:4446-61 pubmed publisher
Cain D, Snowden P, Sempowski G, Kelsoe G. Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism. PLoS ONE. 2011;6:e19957 pubmed publisher
Hegde V, Nagarkatti M, Nagarkatti P. Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties. Eur J Immunol. 2010;40:3358-71 pubmed publisher
Shojaei F, Wu X, Qu X, Kowanetz M, Yu L, Tan M, et al. G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc Natl Acad Sci U S A. 2009;106:6742-7 pubmed publisher
Furze R, Rankin S. The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse. FASEB J. 2008;22:3111-9 pubmed publisher
Brunner S, Zaruba M, Huber B, David R, Vallaster M, Assmann G, et al. Parathyroid hormone effectively induces mobilization of progenitor cells without depletion of bone marrow. Exp Hematol. 2008;36:1157-66 pubmed publisher
Shojaei F, Wu X, ZHONG C, Yu L, Liang X, Yao J, et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature. 2007;450:825-31 pubmed
Wengner A, Pitchford S, Furze R, Rankin S. The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood. 2008;111:42-9 pubmed
Ye P, Rodriguez F, Kanaly S, Stocking K, Schurr J, Schwarzenberger P, et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med. 2001;194:519-27 pubmed

image

image 1 :

Detection of G-CSF antibody in Mouse splenocytes antibody by Flow Cytometry.

product information

brand :

R&D Systems

master code :

MAB414

SKU :

MAB414-100

product name :

G-CSF Antibody

description :

The Mouse G-CSF Antibody from R&D Systems is a rat monoclonal antibody to G-CSF. This antibody reacts with mouse. The Mouse G-CSF Antibody has been validated for the following applications: Western Blot, Neutralization, Intracellular Staining by Flow Cytometry, ELISA Capture (Matched Antibody Pair).

target :

G-CSF

category :

Primary Antibodies

unit sizes :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

67604

conjugate :

Unconjugated

host :

Rat

immunogen :

E. coli -derived recombinant mouse G-CSF, Val31-Ala208, Accession # P09920

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse

specificity :

Detects mouse G-CSF in ELISAs and Western blots. In ELISAs, does not cross-react with recombinant human (rh) G-CSF, rhCNTF, rmIL-6, rmLIF, or rmOSM.

gene symbol :

CSF3

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

accessionNumbers :

P09920

applications :

Western Blot, Neutralization, Intracellular Staining by Flow Cytometry, ELISA Capture (Matched Antibody Pair)

USD :

442 USD

alt names :

C17orf33, chromosome 17 open reading frame 33, colony stimulating factor 3 (granulocyte), CSF3, CSF3OS, Filgrastim, GCSF, G-CSF, GCSFlenograstim, granulocyte colony-stimulating factor, Lenograstim, MGC45931, pluripoietin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage