Human HepaCAM Antibody | R&D Systems MAB4108 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human HepaCAM Antibody

catalog :

MAB4108

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

419305

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry

more info or order :

R&D Systems product webpage

citations: 16

Reference
Jin S, Tian Y, Hacker J, Chen X, Bertolio M, Reynolds C, et al. Inflammatory cytokines disrupt astrocyte exosomal HepaCAM-mediated protection against neuronal excitotoxicity in the SOD1G93A ALS model. Sci Adv. 2024;10:eadq3350 pubmed publisher
Wang M, Zhang L, Novak S, Yu J, Gallina I, Xu L, et al. Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain. Nat Biotechnol. 2024;: pubmed publisher
Jin S, Chen X, Tian Y, Jarvis R, Promes V, Yang Y. Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation. Nat Commun. 2023;14:5150 pubmed publisher
Voss A, Lanjewar S, Sampson M, King A, Hill E, Sing A, et al. Identification of ligand-receptor pairs that drive human astrocyte development. Nat Neurosci. 2023;26:1339-1351 pubmed publisher
Krawczyk M, Pan L, Zhang A, Zhang Y. Lymphocyte deficiency alters the transcriptomes of oligodendrocytes, but not astrocytes or microglia. PLoS ONE. 2023;18:e0279736 pubmed publisher
Pan L, Trimarco A, Zhang A, Fujimori K, Urade Y, Sun L, et al. Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination. elife. 2023;12: pubmed publisher
Sun J, Osenberg S, Irwin A, Ma L, Lee N, Xiang Y, et al. Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation. Cell Rep. 2023;42:111942 pubmed publisher
Nölle A, van Dijken I, Waelti C, Calini D, Bryois J, Lezan E, et al. Enrichment of Glial Cells From Human Post-mortem Tissue for Transcriptome and Proteome Analysis Using Immunopanning. Front Cell Neurosci. 2021;15:772011 pubmed publisher
Guttenplan K, Weigel M, Prakash P, Wijewardhane P, Hasel P, Rufen Blanchette U, et al. Neurotoxic reactive astrocytes induce cell death via saturated lipids. Nature. 2021;599:102-107 pubmed publisher
Li Z, Siddique I, Hadrovi x107 I, Kirupakaran A, Li J, Zhang Y, et al. Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes. Commun Biol. 2021;4:1076 pubmed publisher
Li J, Pan L, Pembroke W, Rexach J, Godoy M, Condro M, et al. Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. Nat Commun. 2021;12:3958 pubmed publisher
Baldwin K, Tan C, Strader S, Jiang C, Savage J, Elorza Vidal X, et al. HepaCAM controls astrocyte self-organization and coupling. Neuron. 2021;109:2427-2442.e10 pubmed publisher
Guttenplan K, Weigel M, Adler D, Couthouis J, Liddelow S, Gitler A, et al. Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model. Nat Commun. 2020;11:3753 pubmed publisher
Henrik Heiland D, Ravi V, Behringer S, Frenking J, Wurm J, Joseph K, et al. Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma. Nat Commun. 2019;10:2541 pubmed publisher
Li J, Khankan R, Caneda C, Godoy M, Haney M, Krawczyk M, et al. Astrocyte-to-astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation. Glia. 2019;67:1571-1597 pubmed publisher
Wu M, Moh M, Schwarz H. HepaCAM associates with connexin 43 and enhances its localization in cellular junctions. Sci Rep. 2016;6:36218 pubmed publisher

product information

master code :

MAB4108

SKU :

MAB4108

product name :

Human HepaCAM Antibody

unit size :

100 ug (also 25 ug)

description :

The Human HepaCAM Antibody from R&D Systems is a mouse monoclonal antibody to HepaCAM. This antibody reacts with human,mouse,transgenic mouse,xenograft. The Human HepaCAM Antibody has been validated for the following applications: Immunocytochemistry,Immunohistochemistry,Immunopanning,Bioassay,Flow Cytometry,Immunoprecipitation,Western Blot,Cell Culture.

target :

HepaCAM

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

419305

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human HepaCAM, Val34-Tyr242, Accession # Q14CZ8

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Transgenic Mouse,Xenograft

specificity :

Detects human HepaCAM in direct ELISAs and Western blots.

gene symbol :

HEPACAM

top caption :

Detection of Human HepaCAM antibody by Western Blot.

accessionNumbers :

Q14CZ8

applications :

Immunopanning,Immunohistochemistry,Bioassay,Flow Cytometry,Immunoprecipitation,Western Blot,Cell Culture

USD :

489 USD

alt names :

cancer susceptibility, FLJ25530, glial cell adhesion molecule, GLIALCAM, hepaCAM, hepatic and glial cell adhesion molecule, hepatocyte cell adhesion molecule, Protein hepaCAM

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage