Human/Mouse Patched 1/PTCH (First Extracellular Loop) Antibody | R&D Systems MAB41051 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse Patched 1/PTCH (First Extracellular Loop) Antibody

catalog :

MAB41051

quantity :

100 ug (also 25 ug)

price :

459 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

413220

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 10

Reference
Suppiah S, Mansouri S, Mamatjan Y, Liu J, Bhunia M, Patil V, et al. Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities. Nat Commun. 2023;14:2696 pubmed publisher
Guahmich N, Man L, Wang J, Arazi L, Kallinos E, Topper Kroog A, et al. Human theca arises from ovarian stroma and is comprised of three discrete subtypes. Commun Biol. 2023;6:7 pubmed publisher
Feliz Morel x, Hasanovic A, Morin A, Prunier C, Magnone V, Lebrigand K, et al. Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched. Pharmaceutics. 2022;14: pubmed publisher
Tanigawa S, Fujita M, Moyama C, Ando S, Ii H, Kojima Y, et al. Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model. Cancer Gene Ther. 2021;: pubmed publisher
Tessier S, Madhu V, Johnson Z, Shapiro I, Risbud M. NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis. Dev Biol. 2019;: pubmed publisher
Sharon N, Vanderhooft J, Straubhaar J, Mueller J, Chawla R, Zhou Q, et al. Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development. Cell Rep. 2019;27:2281-2291.e5 pubmed publisher
Bonavita R, Vincent K, Pinelli R, Dahia C. Formation of the sacrum requires down-regulation of sonic hedgehog signaling in the sacral intervertebral discs. Biol Open. 2018;7: pubmed publisher
Gordon R, Zhang L, Peri S, Kuo Y, Du F, Egleston B, et al. Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma. Clin Cancer Res. 2018;24:1375-1388 pubmed publisher
Vitte J, Gao F, Coppola G, Judkins A, Giovannini M. Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development. Nat Commun. 2017;8:300 pubmed publisher
Lancaster M, Gopal D, Kim J, Saleem S, Silhavy J, Louie C, et al. Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome. Nat Med. 2011;17:726-31 pubmed publisher

product information

master code :

MAB41051

SKU :

MAB41051

product name :

Human/Mouse Patched 1/PTCH (First Extracellular Loop) Antibody

unit size :

100 ug (also 25 ug)

description :

The Human/Mouse Patched 1/PTCH (First Extracellular Loop) Antibody from R&D Systems is a rat monoclonal antibody to Patched 1/PTCH. This antibody reacts with human,mouse. The Human/Mouse Patched 1/PTCH (First Extracellular Loop) Antibody has been validated for the following applications: Western Blot,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

Patched 1/PTCH

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

413220

concentration :

LYOPH

conjugate :

Unconjugated

host :

Rat

immunogen :

E. coli -derived recombinant mouse Patched 1/PTCH, Glu108-Asp422, Accession # Q61115

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects mouse Patched 1/PTCH (First Extracellular Loop) in direct ELISAs and Western blots. In direct ELISAs and Western blots, 15% cross-reactivity with recombinant human Patched 2 is observed.

gene symbol :

PTCH1

top caption :

Detection of Mouse Patched 1/PTCH antibody by Western Blot.

accessionNumbers :

Q61115

applications :

Flow Cytometry,Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

459 USD

alt names :

BCNS, BCNSFLJ42602, FLJ26746, HPE7, mes, NBCCS, patched (Drosophila) homolog, patched 1, patched homolog (Drosophila), patched homolog 1, patched homolog 1 (Drosophila), protein patched homolog 1, PTC, PTC1, PTCH, PTCH protein +12b, PTCH protein +4', PTCH protein -10, PTCH1, PTCH11

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage