product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse/Rat FRS2 Antibody
catalog :
MAB4069
quantity :
100 ug (also 25 ug)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
462910
reactivity :
human, mouse, rat
application :
western blot
more info or order :
R&D Systems product webpage
citations: 13
Reference
O Loughlin E, Zhang Y, Chiasson MacKenzie C, Dave P, Rheinbay E, Stott S, et al. Distinct phenotypic consequences of cholangiocarcinoma-associated FGFR2 alterations depend on biliary epithelial maturity. bioRxiv. 2024;: pubmed publisher
Wang Z, Muthusamy V, Petrylak D, Anderson K. Tackling FGFR3-driven bladder cancer with a promising synergistic FGFR/HDAC targeted therapy. NPJ Precis Oncol. 2023;7:70 pubmed publisher
Subbiah V, Sahai V, Maglic D, Bruderek K, Tour xe9 B, Zhao S, et al. RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations. Cancer Discov. 2023;13:2012-2031 pubmed publisher
Nicholson H, Sawers L, Clarke R, Hiom K, Ferguson M, Smith G. Fibroblast growth factor signalling influences homologous recombination-mediated DNA damage repair to promote drug resistance in ovarian cancer. Br J Cancer. 2022;127:1340-1351 pubmed publisher
Raman R, Villefranc J, Ullmann T, Thiesmeyer J, Anelli V, Yao J, et al. Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer. J Exp Med. 2022;219: pubmed publisher
Liu D, Liu W, Chen X, Yin J, Ma L, Liu M, et al. circKCNN2 suppresses the recurrence of hepatocellular carcinoma at least partially via regulating miR-520c-3p/methyl-DNA-binding domain protein 2 axis. Clin Transl Med. 2022;12:e662 pubmed publisher
Xiang H, Chan A, Ahene A, Bellovin D, Deng R, Hsu A, et al. Preclinical characterization of bemarituzumab, an anti-FGFR2b antibody for the treatment of cancer. MAbs. 2021;13:1981202 pubmed publisher
Wu S, Ou T, Xing N, Lu J, Wan S, Wang C, et al. Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer. Nat Commun. 2019;10:720 pubmed publisher
Terzuoli E, Corti F, Nannelli G, Giachetti A, Donnini S, Ziche M. Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1. Int J Mol Sci. 2018;19: pubmed publisher
Xu L, Meng X, Xu N, Fu W, Tan H, Zhang L, et al. Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth. Cell Death Dis. 2018;9:262 pubmed publisher
Elzi D, Song M, Blackman B, Weintraub S, Lopez Terrada D, Chen Y, et al. FGF19 functions as autocrine growth factor for hepatoblastoma. Genes Cancer. 2016;7:125-35 pubmed publisher
Spichtig D, Zhang H, Mohebbi N, Pavik I, Petzold K, Stange G, et al. Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney disease. Kidney Int. 2014;85:1340-50 pubmed publisher
Bryant M, Marta C, Kim F, Bansal R. Phosphorylation and lipid raft association of fibroblast growth factor receptor-2 in oligodendrocytes. Glia. 2009;57:935-46 pubmed publisher
product information
master code :
MAB4069
SKU :
MAB4069
product name :
Human/Mouse/Rat FRS2 Antibody
unit size :
100 ug (also 25 ug)
description :
The Human/Mouse/Rat FRS2 Antibody from R&D Systems is a mouse monoclonal antibody to FRS2. This antibody reacts with human,mouse,rat,transgenic mouse. The Human/Mouse/Rat FRS2 Antibody has been validated for the following applications: Western Blot.
target :
FRS2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
462910
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant human FRS2, Asn121-Asn449, Accession # Q8WU20
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Rat
specificity :
Detects human, mouse, and rat FRS2 in Western blots.
gene symbol :
FRS2
top caption :
Detection of Human/Mouse/Rat FRS2 antibody by Western Blot.
accessionNumbers :
Q8WU20
applications :
Western Blot
USD :
479 USD
alt names :
FGFR signalling adaptor, FGFR-signaling adaptor SNT, fibroblast growth factor receptor substrate 2, FRS2A, FRS2alpha, SNT, SNT1, SNT-1FGFR substrate 2, Suc1-associated neurotrophic factor target 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.