product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse IL-1▀/IL-1F2 Antibody
catalog :
MAB4011-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
469 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
166926
reactivity :
human, mouse
application :
western blot, immunoprecipitation
more info or order :
R&D Systems product webpage
citations: 10
Reference
Chowdhury D, Gardner J, Satpati A, Nookala S, Mukundan S, Porollo A, et al. Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity. Front Immunol. 2021;12:755961 pubmed publisher
Gomez Lopez N, Romero R, Garcia Flores V, Leng Y, Miller D, Hassan S, et al. Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth, and adverse neonatal outcomes†. Biol Reprod. 2019;100:1306-1318 pubmed publisher
Faro J, Romero R, Schwenkel G, Garcia Flores V, Arenas Hernandez M, Leng Y, et al. Inflammation-Induced Intra-Amniotic inflammation induces preterm birth by Activating the NLRP3 inflammasome. Biol Reprod. 2018;: pubmed publisher
Burgy O, Bellaye P, Causse S, Beltramo G, Wettstein G, Boutanquoi P, et al. Pleural inhibition of the caspase-1/IL-1? pathway diminishes profibrotic lung toxicity of bleomycin. Respir Res. 2016;17:162 pubmed
Kataoka K, Matsumoto H, Kaneko H, Notomi S, Takeuchi K, Sweigard J, et al. Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death. Cell Death Dis. 2015;6:e1731 pubmed publisher
Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, et al. Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gin. J Biol Chem. 2014;289:15621-30 pubmed publisher
Shin J, Fattah E, Bhattacharya A, Ko S, Eissa N. Inflammasome activation by altered proteostasis. J Biol Chem. 2013;288:35886-95 pubmed publisher
Bruchard M, Mignot G, Derangère V, Chalmin F, Chevriaux A, Vegran F, et al. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med. 2013;19:57-64 pubmed publisher
Dunne A, Ross P, Pospisilova E, Masin J, Meaney A, Sutton C, et al. Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis. J Immunol. 2010;185:1711-9 pubmed publisher
Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell R, et al. Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. J Immunol. 2009;183:7890-7 pubmed publisher
product information
master code :
MAB4011
SKU :
MAB4011-100
product name :
Mouse IL-1▀/IL-1F2 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Mouse IL-1ß/IL-1F2 Antibody from R&D Systems is a rat monoclonal antibody to IL-1 beta/IL-1F2. This antibody reacts with bacteria - porphyromonas gingivalis,human,mouse. The Mouse IL-1ß/IL-1F2 Antibody has been validated for the following applications: Western Blot,Immunoprecipitation.
target :
IL-1 beta/IL-1F2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
166926
conjugate :
Unconjugated
host :
Rat
immunogen :
E. coli -derived recombinant mouse IL-1▀, Val118-Ser269, Accession # P10749
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Bacteria - Porphyromonas gingivalis,Human,Mouse
specificity :
Detects mouse IL-1▀ in direct ELISAs and Western blots. In direct ELISAs and Western blots, 25-100% cross-reactivity with human, rat, and cotton rat IL-1▀ is obseved and no cross-reactivity with recombinant porcine IL-1▀, recombinant mouse (rm) IL-1 alpha , or rmIL-18 is observed.
gene symbol :
IL1B
top caption :
Detection of Mouse IL-1ss/IL-1F2 antibody by Western Blot.
accessionNumbers :
P10749
applications :
Western Blot,Immunoprecipitation
USD :
469 USD
alt names :
catabolin, IL-1, IL1 beta, IL-1 beta, IL-1b, IL1B, IL1-BETA, IL-1F2, IL1F2IL-1 beta, interleukin 1, beta, interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.