IL-1 beta/IL-1F2 Antibody | R&D Systems MAB401-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

IL-1 beta/IL-1F2 Antibody

catalog :

MAB401-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

453 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

30311

reactivity :

mouse

application :

ELISA, neutralization

more info or order :

R&D Systems product webpage

citations: 35

Reference
Hwang Y, Kim H, Shin E. Effect of rottlerin on astrocyte phenotype polarization after trimethyltin insult in the dentate gyrus of mice. J Neuroinflammation. 2022;19:142 pubmed publisher
Shippy D, Wilhelm C, Viharkumar P, Raife T, Ulland T. β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology. J Neuroinflammation. 2020;17:280 pubmed publisher
Cai S, Ge M, Mennone A, Hoque R, Ouyang X, Boyer J. Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct-Ligated Mouse. Cell Mol Gastroenterol Hepatol. 2020;9:679-688 pubmed publisher
Kim D, Choi J, Jo I, Kim M, Lee H, Hong S, et al. Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway. Mol Med Rep. 2020;21:258-266 pubmed publisher
Pang Z, Raudonis R, McCormick C, Cheng Z. Early Growth Response 1 Deficiency Protects the Host against Pseudomonas aeruginosa Lung Infection. Infect Immun. 2019;88: pubmed publisher
Sul O, Rajasekaran M, Park H, Suh J, Choi H. MicroRNA-29b Enhances Osteoclast Survival by Targeting BCL-2-Modifying Factor after Lipopolysaccharide Stimulation. Oxid Med Cell Longev. 2019;2019:6018180 pubmed publisher
Polykratis A, Martens A, Eren R, Shirasaki Y, Yamagishi M, Yamaguchi Y, et al. A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain. Nat Cell Biol. 2019;21:731-742 pubmed publisher
Kolb R, Kluz P, Tan Z, Borcherding N, Bormann N, Vishwakarma A, et al. Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Oncogene. 2019;38:2351-2363 pubmed publisher
Zhong Z, Liang S, Sanchez Lopez E, He F, Shalapour S, Lin X, et al. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018;560:198-203 pubmed publisher
Mehta A, Doherty T, Broide D, Croft M. Tumor necrosis factor family member LIGHT acts with IL-1β and TGF-β to promote airway remodeling during rhinovirus infection. Allergy. 2018;73:1415-1424 pubmed publisher
Pang Z, Junkins R, MacNeil A, McCormick C, Cheng Z, Chen W, et al. The calcineurin-NFAT axis contributes to host defense during Pseudomonas aeruginosa lung infection. J Leukoc Biol. 2017;: pubmed publisher
Oh Y, Kwon Y, Jung B. Anti-inflammatory Effects of the Natural Compounds Cortex Phellodendri and Humulus japonicus on Pelvic Inflammatory Disease in Mice. Int J Med Sci. 2017;14:729-734 pubmed publisher
Zhang L, Tian Z, Li W, Wang X, Man Z, Sun S. Inhibitory effect ofquercetinon titaniumparticle-inducedendoplasmic reticulum stress (ERS)-related apoptosisandin vivoosteolysis. Biosci Rep. 2017;: pubmed publisher
Nam S, Kim K, Kim M, Jang J, Rah S, Chae H, et al. Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan. Pharm Biol. 2017;55:1856-1862 pubmed publisher
Dhar P, Ng G, Dunne E, Sutton P. Mucin 1 protects against severe Streptococcus pneumoniae infection. Virulence. 2017;8:1631-1642 pubmed publisher
Dempsey C, Rubio Araiz A, Bryson K, Finucane O, Larkin C, Mills E, et al. Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-? and cognitive function in APP/PS1 mice. Brain Behav Immun. 2017;61:306-316 pubmed publisher
Ha S, Sung J, Choi I, Kim Y. Oryza sativa (Rice) Hull Extract Inhibits Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages by Suppressing Extracellular Signal-regulated Kinase, c-Jun N-terminal Kinase, and Nuclear Factor-κB Activation. Pharmacogn Mag. 2016;12:295-301 pubmed
Kim L, Morita R, Kobayashi Y, Eisenbarth S, Lee C, Elias J, et al. AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites. Proc Natl Acad Sci U S A. 2015;112:E2891-9 pubmed publisher
Lalani A, Moore C, Luo C, Kreider B, Liu Y, Morse H, et al. Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice. J Immunol. 2015;194:334-48 pubmed publisher
Ingham V, Williams A, Bate C. Glimepiride reduces CD14 expression and cytokine secretion from macrophages. J Neuroinflammation. 2014;11:115 pubmed publisher
Bakker P, Butter L, Claessen N, Teske G, Sutterwala F, Florquin S, et al. A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion. Am J Pathol. 2014;184:2013-22 pubmed publisher
Benahmed F, Chyou S, Dasoveanu D, Chen J, Kumar V, Iwakura Y, et al. Multiple CD11c+ cells collaboratively express IL-1? to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth. J Immunol. 2014;192:4153-63 pubmed publisher
Junkins R, MacNeil A, Wu Z, McCormick C, Lin T. Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. J Immunol. 2013;190:5178-86 pubmed publisher
Eisenbarth S, Williams A, Colegio O, Meng H, Strowig T, Rongvaux A, et al. NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2012;484:510-3 pubmed publisher
Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, et al. Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine. 2012;58:169-77 pubmed publisher
Wu W, Mehta H, Chakrabarty K, Booth J, Duggan E, Patel K, et al. Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin. J Immunol. 2009;183:5799-806 pubmed publisher
Scatizzi J, Mavers M, Hutcheson J, Young B, Shi B, Pope R, et al. The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages. Eur J Immunol. 2009;39:820-5 pubmed publisher
Maelfait J, Vercammen E, Janssens S, Schotte P, Haegman M, Magez S, et al. Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J Exp Med. 2008;205:1967-73 pubmed publisher
Smith S, Li J, Garbett K, Mirnics K, Patterson P. Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci. 2007;27:10695-702 pubmed
Cunha T, Verri W, Fukada S, Guerrero A, Santodomingo Garzon T, Poole S, et al. TNF-alpha and IL-1beta mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor. Eur J Pharmacol. 2007;573:221-9 pubmed
Penido C, Conte F, Chagas M, Rodrigues C, Pereira J, Henriques M. Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice. Inflamm Res. 2006;55:457-64 pubmed
Osuchowski M, Welch K, Siddiqui J, Remick D. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol. 2006;177:1967-74 pubmed
Dajee M, Muchamuel T, Schryver B, Oo A, Alleman Sposeto J, De Vry C, et al. Blockade of experimental atopic dermatitis via topical NF-kappaB decoy oligonucleotide. J Invest Dermatol. 2006;126:1792-803 pubmed
Osuchowski M, Siddiqui J, Copeland S, Remick D. Sequential ELISA to profile multiple cytokines from small volumes. J Immunol Methods. 2005;302:172-81 pubmed
Ellaban E, Bolgos G, Remick D. Selective macrophage suppression during sepsis. Cell Immunol. 2004;231:103-11 pubmed

image

image 1 :

Cell Proliferation Induced by IL-1ss/IL-1F2 and Neutral-ization by Mouse IL-1ss/IL-1F2 Antibody.

product information

brand :

R&D Systems

master code :

MAB401

SKU :

MAB401-100

product name :

IL-1 beta/IL-1F2 Antibody

description :

The Mouse IL-1 beta/IL-1F2 Antibody from R&D Systems is a rat monoclonal antibody to IL-1 beta/IL-1F2. This antibody reacts with mouse. The Mouse IL-1 beta/IL-1F2 Antibody has been validated for the following applications: Neutralization, ELISA Capture (Matched Antibody Pair).

target :

IL-1 beta/IL-1F2

category :

Primary Antibodies

unit sizes :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

30311

conjugate :

Unconjugated

host :

Rat

immunogen :

E. coli -derived recombinant mouse IL-1 beta/IL-1F2, Val118-Ser269, Accession # P10749

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse

specificity :

Detects mouse IL-1 beta/IL-1F2 in ELISAs.

gene symbol :

IL1B

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

accessionNumbers :

P10749

applications :

Neutralization, ELISA Capture (Matched Antibody Pair)

USD :

453 USD

alt names :

catabolin, IL-1, IL1 beta, IL-1 beta, IL-1b, IL1B, IL1-BETA, IL-1F2, IL1F2IL-1 beta, interleukin 1, beta, interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage