TrkB Antibody | R&D Systems MAB397-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

TrkB Antibody

catalog :

MAB397-100

quantity :

100 ug (also 500 ug, 25 ug)

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

75133

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

R&D Systems product webpage

citations: 6

Reference
Xiong J, Liao J, Liu X, Zhang Z, Adams J, Pacifici R, et al. A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin. Nat Commun. 2022;13:4820 pubmed publisher
Wang Z, Xiang J, Liu X, Yu S, Manfredsson F, Sandoval I, et al. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell Rep. 2019;28:655-669.e5 pubmed publisher
Tanaka K, Okugawa Y, Toiyama Y, Inoue Y, Saigusa S, Kawamura M, et al. Brain-derived neurotrophic factor (BDNF)-induced tropomyosin-related kinase B (Trk B) signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal cancer. PLoS ONE. 2014;9:e96410 pubmed publisher
Rossing K, Novak N, Mommert S, Pfab F, Gehring M, Wedi B, et al. Brain-derived neurotrophic factor is increased in serum and skin levels of patients with chronic spontaneous urticaria. Clin Exp Allergy. 2011;41:1392-9 pubmed publisher
Raap U, Fokkens W, Bruder M, Hoogsteden H, Kapp A, Braunstahl G. Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis. Allergy. 2008;63:468-75 pubmed publisher
Gleissner C, Zastrow A, Klingenberg R, Kluger M, Konstandin M, Celik S, et al. IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells. Eur J Immunol. 2007;37:177-92 pubmed

image

image 1 :

Detection of Human, Mouse, and Rat TrkB antibody by Western Blot.

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

MAB397

SKU :

MAB397-100

product name :

TrkB Antibody

Description :

The Human/Mouse/Rat TrkB Antibody from R&D Systems is a mouse monoclonal antibody to TrkB. This antibody reacts with human, mouse, rat. The Human/Mouse/Rat TrkB Antibody has been validated for the following applications: Western Blot, Immunohistochemistry.

target :

TrkB

category :

Primary Antibodies

unit size :

100 ug (also 500 ug, 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

75133

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human TrkB, Cys32-His430, Accession # Q16620

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human, Mouse, Rat

specificity :

Detects human TrkB in direct ELISAs. Detects human, mouse, and rat TrkB in Western blots. In ELISAs and Western blots, no cross-reactivity with recombinant human (rh) TrkA, rhTrkC, or recombinant rat TrkA is observed.

gene symbol :

NTRK2

accessionNumbers :

Q16620

applications :

Western Blot, Immunohistochemistry

USD :

459 USD

alt names :

BDNF/NT-3 growth factors receptor, EC 2.7.10, EC 2.7.10.1, GP145-TrkB, Neurotrophic tyrosine kinase receptor type 2, neurotrophic tyrosine kinase, receptor, type 2, NTRK2, trk-B, TrkB tyrosine kinase, TRKBBDNF-tropomyosine receptor kinase B, tyrosine kinase receptor B

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage