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company name :
R&D Systems
product type :
antibody
product name :
Human Nrf2 Antibody
catalog :
MAB3925
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
383727
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, neutralization
more info or order :
citations: 37
Reference
Jramne Saleem Y, Danilenko M. Roles of Glutathione and AP-1 in the Enhancement of Vitamin D-Induced Differentiation by Activators of the Nrf2 Signaling Pathway in Acute Myeloid Leukemia Cells. Int J Mol Sci. 2024;25: pubmed publisher
Park J, Park C. Effects of In Vitro Combination of Nitric Oxide Donors and Hypochlorite on Acanthamoeba castellanii Viability. Transl Vis Sci Technol. 2023;12:23 pubmed publisher
Guerrero Bobadilla C, Y xe1 xf1 ez S xe1 nchez I, Franco xc1 vila T, Mart xed nez Rizo A, Dom xed nguez Rosales A, Alvarez Rodr xed guez B, et al. Reduction of NrF2 as coadjuvant during the development of persistent periapical lesions. Med Oral Patol Oral Cir Bucal. 2023;28:e404-e411 pubmed publisher
Mas G, Man N, Nakata Y, Martinez Caja C, Karl D, Beckedorff F, et al. The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression. J Clin Invest. 2023;133: pubmed publisher
Park J, Lee K, Park C. Effect of Magnetic Microparticles on Cultivated Human Corneal Endothelial Cells. Transl Vis Sci Technol. 2023;12:14 pubmed publisher
Sasaki S, Negishi T, Tsuzuki T, Yukawa K. Diphenylarsinic acid induced activation of MAP kinases, transcription factors, and oxidative stress-responsive factors and hypersecretion of cytokines in cultured normal human cerebellar astrocytes. Neurotoxicology. 2022;88:196-207 pubmed publisher
Mikul x10d i x107 M, Tabrizi Wizsy N, Bernhart E, Asslaber M, Trummer C, Windischhofer W, et al. 15d-PGJ2 Promotes ROS-Dependent Activation of MAPK-Induced Early Apoptosis in Osteosarcoma Cell In Vitro and in an Ex Ovo CAM Assay. Int J Mol Sci. 2021;22: pubmed publisher
Sayed W. Quercetin Alleviates Red Bull Energy Drink-Induced Cerebral Cortex Neurotoxicity via Modulation of Nrf2 and HO-1. Oxid Med Cell Longev. 2021;2021:9482529 pubmed publisher
Zhao S, Chen W, Li W, Yu W, Li S, Rao T, et al. LncRNA TUG1 attenuates ischaemia-reperfusion-induced apoptosis of renal tubular epithelial cells by sponging miR-144-3p via targeting Nrf2. J Cell Mol Med. 2021;25:9767-9783 pubmed publisher
Kaufman G, Skrtic D. N-Acetyl Cysteine Modulates the Inflammatory and Oxidative Stress Responses of Rescued Growth-Arrested Dental Pulp Microtissues Exposed to TEGDMA in ECM. Int J Mol Sci. 2020;21: pubmed publisher
Roy A, Sharma A, Nellore K, Narkar V, Kumar A. TAK1 preserves skeletal muscle mass and mitochondrial function through redox homeostasis. FASEB Bioadv. 2020;2:538-553 pubmed publisher
Yuan X, Fu Z, Ji P, Guo L, Al Ghamdy A, Alkandiri A, et al. Selenium Nanoparticles Pre-Treatment Reverse Behavioral, Oxidative Damage, Neuronal Loss and Neurochemical Alterations in Pentylenetetrazole-Induced Epileptic Seizures in Mice. Int J Nanomedicine. 2020;15:6339-6353 pubmed publisher
Eve A, Liu X, Wang Y, Miller M, Jeffery E, Madak Erdogan Z. Biomarkers of Broccoli Consumption: Implications for Glutathione Metabolism and Liver Health. Nutrients. 2020;12: pubmed publisher
Chaves Cayuela N, Kiyomi Koike M, Jacysyn J, Rasslan R, Azevedo Cerqueira A, Pereira Costa S, et al. N-Acetylcysteine Reduced Ischemia and Reperfusion Damage Associated with Steatohepatitis in Mice. Int J Mol Sci. 2020;21: pubmed publisher
Manivanh R, Mehrbach J, Charron A, Grassetti A, Cerón S, Taylor S, et al. Herpes Simplex Virus 1 ICP34.5 Alters Mitochondrial Dynamics in Neurons. J Virol. 2020;94: pubmed publisher
Shytaj I, Lucic B, Forcato M, Penzo C, Billingsley J, Laketa V, et al. Alterations of redox and iron metabolism accompany the development of HIV latency. EMBO J. 2020;39:e102209 pubmed publisher
Al Megrin W, Soliman D, Kassab R, Metwally D, Ahmed E Abdel Moneim -, El Khadragy M. Coenzyme Q10 Activates the Antioxidant Machinery and Inhibits the Inflammatory and Apoptotic Cascades Against Lead Acetate-Induced Renal Injury in Rats. Front Physiol. 2020;11:64 pubmed publisher
Al Megrin W, Alkhuriji A, Yousef A, Metwally D, Habotta O, Kassab R, et al. Antagonistic Efficacy of Luteolin against Lead Acetate Exposure-Associated with Hepatotoxicity is Mediated via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Activities. Antioxidants (Basel). 2019;9: pubmed publisher
Almeer R, AlBasher G, Alarifi S, Alkahtani S, Ali D, Abdel Moneim A. Royal jelly attenuates cadmium-induced nephrotoxicity in male mice. Sci Rep. 2019;9:5825 pubmed publisher
Wang J, Zhao J, Cui X, Mysona B, Navneet S, Saul A, et al. The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2. Free Radic Biol Med. 2019;134:604-616 pubmed publisher
Zhao H, Wang R, Ye M, Zhang L. Genipin protects against H2O2-induced oxidative damage in retinal pigment epithelial cells by promoting Nrf2 signaling. Int J Mol Med. 2019;43:936-944 pubmed publisher
Peris E, Micallef P, Paul A, Palsdottir V, Enejder A, Bauzá Thorbrügge M, et al. Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes. J Biol Chem. 2019;294:2340-2352 pubmed publisher
Biernacki M, Ambrożewicz E, Gęgotek A, Toczek M, Skrzydlewska E. Long-term administration of fatty acid amide hydrolase inhibitor (URB597) to rats with spontaneous hypertension disturbs liver redox balance and phospholipid metabolism. Adv Med Sci. 2019;64:15-23 pubmed publisher
Biernacki M, Łuczaj W, Jarocka Karpowicz I, Ambrożewicz E, Toczek M, Skrzydlewska E. The Effect of Long-Term Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism in the Heart of Rats with Primary and Secondary Hypertension. Molecules. 2018;23: pubmed publisher
Liu B, Xu L, Yu X, Li W, Sun X, Xiao S, et al. Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF‑α. Mol Med Rep. 2018;18:1987-1994 pubmed publisher
Weyemi U, Paul B, Snowman A, Jailwala P, Nussenzweig A, Bonner W, et al. Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis. Nat Commun. 2018;9:1526 pubmed publisher
Fu Z, Wang Z, Liu C, Gong Y, Cakir B, Liegl R, et al. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018;67:974-985 pubmed publisher
He W, Xu Y, Zhang C, Lü J, Li J, Xiang D, et al. Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes. Drug Des Devel Ther. 2017;11:3449-3460 pubmed publisher
Kontostathi G, Zoidakis J, Makridakis M, Lygirou V, Mermelekas G, Papadopoulos T, et al. Cervical Cancer Cell Line Secretome Highlights the Roles of Transforming Growth Factor-Beta-Induced Protein ig-h3, Peroxiredoxin-2, and NRF2 on Cervical Carcinogenesis. Biomed Res Int. 2017;2017:4180703 pubmed publisher
Lin J, Xu F, Wang G, Kong L, Luo Q, Lv Y, et al. Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke. Evid Based Complement Alternat Med. 2016;2016:1698379 pubmed publisher
Liśkiewicz A, Kasprowska D, Wojakowska A, Polański K, Lewin Kowalik J, Kotulska K, et al. Long-term High Fat Ketogenic Diet Promotes Renal Tumor Growth in a Rat Model of Tuberous Sclerosis. Sci Rep. 2016;6:21807 pubmed publisher
Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, et al. Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions. J Biol Chem. 2015;290:9738-52 pubmed publisher
Shan Y, Akram A, Amatullah H, Zhou D, Gali P, Maron Gutierrez T, et al. ATF3 protects pulmonary resident cells from acute and ventilator-induced lung injury by preventing Nrf2 degradation. Antioxid Redox Signal. 2015;22:651-68 pubmed publisher
Toosi S, Orlow S, Manga P. Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8. J Invest Dermatol. 2012;132:2601-9 pubmed publisher
Vomhof DeKrey E, Picklo M. NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes. Free Radic Biol Med. 2012;53:690-700 pubmed publisher
Cross S, Cook D, Chi A, Vance P, Kolson L, Wong B, et al. Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. J Immunol. 2011;187:5015-25 pubmed publisher
Scofield V, Yan M, Kuang X, Kim S, Wong P. The drug monosodium luminol (GVT) preserves crypt-villus epithelial organization and allows survival of intestinal T cells in mice infected with the ts1 retrovirus. Immunol Lett. 2009;122:150-8 pubmed publisher
product information
brand :
R&D Systems
master code :
MAB3925
SKU :
MAB3925
product name :
Human Nrf2 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Nrf2 Antibody from R&D Systems is a mouse monoclonal antibody to Nrf2. This antibody reacts with human,mouse,rat. The Human Nrf2 Antibody has been validated for the following applications: Western Blot,Neutralization,Immunocytochemistry.
target :
Nrf2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
383727
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL
host :
Mouse
immunogen :
E. coli -derived recombinant human Nrf2, Met17-Asn605, Accession # Q16236
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Rat
specificity :
Detects human Nrf2 in Western blots. In Western blots, no cross-reactivity with mouse and rat Nrf2 and human Nrf1 is observed.
gene symbol :
NFE2L2
top caption :
Detection of Human Nrf2 antibody by Western Blot.
accessionNumbers :
Q16236
applications :
Western Blot,Neutralization,Immunocytochemistry
USD :
499 USD
alt names :
HEBP1, NFE2L2, NF-E2-related factor 2, NFE2-related factor 2, NRF2 erythroid derived 2, like 2, nuclear factor (erythroid-derived 2)-like 2, nuclear factor erythroid 2-related factor 2, nuclear factor erythroid-derived 2-like 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.