Human/Mouse IGF-I R/IGF1R Antibody | R&D Systems MAB391 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse IGF-I R/IGF1R Antibody

catalog :

MAB391

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

33255

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments

citations: 19

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; loading ...; fig s2a	Crosby P, Hamnett R, Putker M, Hoyle N, Reed M, Karam C, et al. Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time. Cell. 2019;177:896-909.e20 pubmed publisher
blocking or activating experiments; human; fig 3d	Bekkering S, Arts R, Novakovic B, Kourtzelis I, van der Heijden C, Li Y, et al. Metabolic Induction of Trained Immunity through the Mevalonate Pathway. Cell. 2018;172:135-146.e9 pubmed publisher
flow cytometry; human; 1:50; loading ...; fig s2b	Ebbing E, Medema J, Damhofer H, Meijer S, Krishnadath K, van Berge Henegouwen M, et al. ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3. Oncotarget. 2016;7:10243-54 pubmed publisher
	Li J, Weber E, Guth Gundel S, Schuleit M, Kuttler A, Halleux C, et al. Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs. Adv Healthc Mater. 2018;7:e1701393 pubmed publisher
	Neuzillet Y, Chapeaublanc E, Krucker C, de Koning L, Lebret T, Radvanyi F, et al. IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer. BMC Cancer. 2017;17:636 pubmed publisher
	Puvanenthiran S, Essapen S, Seddon A, Modjtahedi H. Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase inhibitors and cytotoxic drugs. Int J Oncol. 2016;49:1825-1838 pubmed publisher
	Gschweitl M, Ulbricht A, Barnes C, Enchev R, Stoffel Studer I, Meyer Schaller N, et al. A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes. elife. 2016;5:e13841 pubmed publisher
	Garwood C, Ratcliffe L, Morgan S, Simpson J, Owens H, Vazquez VillaseÃ±or I, et al. Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Mol Brain. 2015;8:51 pubmed publisher
	Cardillo T, Trisal P, Arrojo R, Goldenberg D, Chang C. Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro. BMC Cancer. 2013;13:170 pubmed publisher
	Suh H, Zhao M, Derico L, Choi N, Lee S. Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators. J Neuroinflammation. 2013;10:37 pubmed publisher
	Jacques C, Holzenberger M, Mladenovic Z, Salvat C, Pecchi E, Berenbaum F, et al. Proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (Nampt) involve regulation of insulin signaling pathway and Nampt enzymatic activity. J Biol Chem. 2012;287:15100-8 pubmed publisher
	Massoner P, Ladurner Rennau M, Heidegger I, Kloss Brandstätter A, Summerer M, Reichhart E, et al. Expression of the IGF axis is decreased in local prostate cancer but enhanced after benign prostate epithelial differentiation and TGF-? treatment. Am J Pathol. 2011;179:2905-19 pubmed publisher
	Wang N, Fallavollita L, Nguyen L, Burnier J, Rafei M, Galipeau J, et al. Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases. Mol Ther. 2009;17:1241-9 pubmed publisher
	Bäck K, Arnqvist H. Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes. Growth Horm IGF Res. 2009;19:101-11 pubmed publisher
	Riccioni R, Senese M, Diverio D, Riti V, Mariani G, Boe A, et al. Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels. Leuk Res. 2008;32:1244-58 pubmed publisher
	Garderet L, Mazurier C, Chapel A, Ernou I, Boutin L, Holy X, et al. Mesenchymal stem cell abnormalities in patients with multiple myeloma. Leuk Lymphoma. 2007;48:2032-41 pubmed
	Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, et al. Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. Stem Cells. 2007;25:1862-71 pubmed
	Spicer L, Aad P. Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor. Biol Reprod. 2007;77:18-27 pubmed
	Quirk S, Cowan R, Harman R. The susceptibility of granulosa cells to apoptosis is influenced by oestradiol and the cell cycle. J Endocrinol. 2006;189:441-53 pubmed

product information

brand :

R&D Systems

master code :

MAB391

SKU :

MAB391-100

product name :

Human/Mouse IGF-I R/IGF1R Antibody

description :

The Human/Mouse IGF-I R/IGF1R Antibody from R&D Systems is a mouse monoclonal antibody to IGF-I R/IGF1R. This antibody reacts with human, mouse. The Human/Mouse IGF-I R/IGF1R Antibody has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Neutralization, Immunocytochemistry, ELISA Capture (Matched Antibody Pair).

target :

IGF-I R/IGF1R

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

33255

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21 -derived recombinant human IGF-I R/IGF1R, Glu31-Asn932, Accession # P08069

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human, Mouse

specificity :

Detects human IGF-I R/IGF1R in sandwich ELISAs and Western blots. Detects mouse IGF-I R/IGF1R in Immunohistochemistry. In sandwich immunoassays, less than 0.15% cross-reactivity or interference was observed with recombinant human (rh) IGF-I, rhIGF-II, rhIL-3 R alpha , rhIL-9 R, and rhTGF-beta RII.

gene symbol :

IGF1R

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB391

accessionNumbers :

P08069

applications :

Western Blot, Flow Cytometry, Immunohistochemistry, Neutralization, Immunocytochemistry, ELISA Capture (Matched Antibody Pair)

2020 USD :

339

2021 USD :

369 USD

alt names :

CD221, CD221 antigen, EC 2.7.10, EC 2.7.10.1, IGF1R, IGF-1R, IGF-I receptor, IGFIR, IGF-IR, IGFR, insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, JTK13, MGC142170, MGC142172, MGC18216, soluble IGF1R variant 1, soluble IGF1R variant 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.