Human/Mouse IGF-I R/IGF1R Antibody | R&D Systems MAB391-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse IGF-I R/IGF1R Antibody

catalog :

MAB391-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

33255

reactivity :

human, mouse, bovine

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 32

Reference
Ishihara H, Otani Y, Tanaka K, Miyajima H, Ngo H, Fujitani M. Blocking insulin-like growth factor 1 receptor signaling pathway inhibits neuromuscular junction regeneration after botulinum toxin-A treatment. Cell Death Dis. 2023;14:609 pubmed publisher
Miyagawa K, Tenshin H, Mulcrone P, Delgado Calle J, Subler M, Windle J, et al. Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation. JCI Insight. 2023;8: pubmed publisher
Jdeed S, Erd x151 s E, B xe1 lint B, Uray I. The Role of ARID1A in the Nonestrogenic Modulation of IGF-1 Signaling. Mol Cancer Res. 2022;20:1071-1082 pubmed publisher
Khan T, Seddon A, Dalgleish A, Khelwatty S, Ioannou N, Mudan S, et al. Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations: Implications for future clinical trials in pancr. Oncol Rep. 2020;44:2581-2594 pubmed publisher
Crosby P, Hamnett R, Putker M, Hoyle N, Reed M, Karam C, et al. Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time. Cell. 2019;177:896-909.e20 pubmed publisher
Ratcliffe L, Vázquez Villaseñor I, Jennings L, Heath P, Mortiboys H, Schwartzentruber A, et al. Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons. Neuroscience. 2018;390:46-59 pubmed publisher
Li J, Weber E, Guth Gundel S, Schuleit M, Kuttler A, Halleux C, et al. Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs. Adv Healthc Mater. 2018;7:e1701393 pubmed publisher
Neuzillet Y, Chapeaublanc E, Krucker C, de Koning L, Lebret T, Radvanyi F, et al. IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer. BMC Cancer. 2017;17:636 pubmed publisher
Puvanenthiran S, Essapen S, Seddon A, Modjtahedi H. Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase inhibitors and cytotoxic drugs. Int J Oncol. 2016;49:1825-1838 pubmed publisher
Yu V, Lymperi S, Oki T, Jones A, Swiatek P, Vasic R, et al. Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow. Stem Cell Reports. 2016;7:220-35 pubmed publisher
Gschweitl M, Ulbricht A, Barnes C, Enchev R, Stoffel Studer I, Meyer Schaller N, et al. A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes. elife. 2016;5:e13841 pubmed publisher
Thomsen J, Hjortebjerg R, Espelund U, Ã˜rtoft G, Vestergaard P, Magnusson N, et al. PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma. Oncotarget. 2015;6:32266-78 pubmed publisher
Garwood C, Ratcliffe L, Morgan S, Simpson J, Owens H, Vazquez VillaseÃ±or I, et al. Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Mol Brain. 2015;8:51 pubmed publisher
Lovly C, McDonald N, Chen H, Ortiz Cuaran S, Heukamp L, Yan Y, et al. Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer. Nat Med. 2014;20:1027-34 pubmed publisher
Renna M, Bento C, Fleming A, Menzies F, Siddiqi F, Ravikumar B, et al. IGF-1 receptor antagonism inhibits autophagy. Hum Mol Genet. 2013;22:4528-44 pubmed publisher
Rettew A, Young E, Lev D, Kleinerman E, Abdul Karim F, Getty P, et al. Multiple receptor tyrosine kinases promote the in vitro phenotype of metastatic human osteosarcoma cell lines. Oncogenesis. 2012;1:e34 pubmed publisher
Bid H, London C, Gao J, Zhong H, Hollingsworth R, Fernandez S, et al. Dual targeting of the type 1 insulin-like growth factor receptor and its ligands as an effective antiangiogenic strategy. Clin Cancer Res. 2013;19:2984-94 pubmed publisher
Cardillo T, Trisal P, Arrojo R, Goldenberg D, Chang C. Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro. BMC Cancer. 2013;13:170 pubmed publisher
Suh H, Zhao M, Derico L, Choi N, Lee S. Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators. J Neuroinflammation. 2013;10:37 pubmed publisher
Chang C, Wang Y, Trisal P, Li R, Rossi D, Nair A, et al. Evaluation of a novel hexavalent humanized anti-IGF-1R antibody and its bivalent parental IgG in diverse cancer cell lines. PLoS ONE. 2012;7:e44235 pubmed publisher
Jacques C, Holzenberger M, Mladenovic Z, Salvat C, Pecchi E, Berenbaum F, et al. Proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (Nampt) involve regulation of insulin signaling pathway and Nampt enzymatic activity. J Biol Chem. 2012;287:15100-8 pubmed publisher
Massoner P, Ladurner Rennau M, Heidegger I, Kloss Brandstätter A, Summerer M, Reichhart E, et al. Expression of the IGF axis is decreased in local prostate cancer but enhanced after benign prostate epithelial differentiation and TGF-? treatment. Am J Pathol. 2011;179:2905-19 pubmed publisher
Vishwamitra D, Shi P, Wilson D, Manshouri R, Vega F, Schlette E, et al. Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma. Haematologica. 2011;96:871-80 pubmed publisher
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Xu L, Hausmann M, Dietmaier W, Kellermeier S, Pesch T, Stieber Gunckel M, et al. Expression of growth factor receptors and targeting of EGFR in cholangiocarcinoma cell lines. BMC Cancer. 2010;10:302 pubmed publisher
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product information

brand :

R&D Systems

master code :

MAB391

SKU :

MAB391-100

product name :

Human/Mouse IGF-I R/IGF1R Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human/Mouse IGF-I R/IGF1R Antibody from R&D Systems is a mouse monoclonal antibody to IGF-I R/IGF1R. This antibody reacts with bovine,human,mouse. The Human/Mouse IGF-I R/IGF1R Antibody has been validated for the following applications: Neutralization,ELISA Development,Flow Cytometry,Western Blot,ELISA Capture,Immunohistochemistry-Paraffin,In vivo assay,Immunocytochemistry,Immunohistochemistry,ELISA Capture (Matched Antibody Pair).

target :

IGF-I R/IGF1R

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

33255

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 5-25 ug/mL, Neutralization, Immunocytochemistry 3-25 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21 -derived recombinant human IGF-I R/IGF1R, Glu31-Asn932, Accession # P08069

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Bovine,Human,Mouse

specificity :

Detects human IGF-I R/IGF1R in sandwich ELISAs and Western blots. Detects mouse IGF-I R/IGF1R in Immunohistochemistry. In sandwich immunoassays, less than 0.15% cross-reactivity or interference was observed with recombinant human (rh) IGF-I, rhIGF-II, rhIL-3 R alpha , rhIL-9 R, and rhTGF┐▀ RII.

gene symbol :

IGF1R

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Human IGF-I R/IGF1R antibody by Western Blot.

accessionNumbers :

P08069

applications :

Immunohistochemistry,ELISA Capture (Matched Antibody Pair),ELISA Development,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,In vivo assay,Neutralization,Immunocytochemistry,ELISA Capture

USD :

499 USD

alt names :

CD221, CD221 antigen, EC 2.7.10, EC 2.7.10.1, IGF1R, IGF-1R, IGF-I receptor, IGFIR, IGF-IR, IGFR, insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, JTK13, MGC142170, MGC142172, MGC18216, soluble IGF1R variant 1, soluble IGF1R variant 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage