Human Neuregulin-1/NRG1 Antibody | R&D Systems MAB377 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Neuregulin-1/NRG1 Antibody

catalog :

MAB377

quantity :

100 ug (also 25 ug, 500 ug)

price :

359 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

147724

reactivity :

human, mouse

application :

western blot, immunohistochemistry - frozen section

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s6b	Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, et al. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nat Commun. 2019;10:1365 pubmed publisher
	Shi D, Li L, Bian X, Shi X, Lu L, Zhou H, et al. miR-296-5p suppresses EMT of hepatocellular carcinoma via attenuating NRG1/ERBB2/ERBB3 signaling. J Exp Clin Cancer Res. 2018;37:294 pubmed publisher
	Rahim T, Becquart P, Baeva M, Quandt J. Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis. J Neuroinflammation. 2018;15:270 pubmed publisher
	Rhyasen G, Yao Y, Zhang J, Dulak A, Castriotta L, Jacques K, et al. BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors. PLoS ONE. 2018;13:e0200826 pubmed publisher
	Choi Y, Maki T, Mandeville E, Koh S, Hayakawa K, Arai K, et al. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016;22:1335-1341 pubmed publisher
	Capparelli C, Rosenbaum S, Berger A, Aplin A. Fibroblast-derived neuregulin 1 promotes compensatory ErbB3 receptor signaling in mutant BRAF melanoma. J Biol Chem. 2015;290:24267-77 pubmed publisher
	Paul B, Blanchard Z, Ridgway M, ElShamy W. BRCA1-IRIS inactivation sensitizes ovarian tumors to cisplatin. Oncogene. 2015;34:3036-52 pubmed publisher
	Chua Y, Ito Y, Pole J, Newman S, Chin S, Stein R, et al. The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene. Oncogene. 2009;28:4041-52 pubmed publisher
	Heinisch S, Kirby L. Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuroscience. 2009;164:1210-23 pubmed publisher

product information

brand :

R&D Systems

master code :

MAB377

SKU :

MAB377-100

product name :

Human Neuregulin-1/NRG1 Antibody

description :

The Human Neuregulin-1/NRG1 Antibody from R&D Systems is a mouse monoclonal antibody to Neuregulin-1/NRG1. This antibody reacts with human. The Human Neuregulin-1/NRG1 Antibody has been validated for the following applications: Western Blot.

target :

Neuregulin-1/NRG1

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

147724

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human Neuregulin-1/NRG1, Ser2-Lys246, Accession # AAA58639

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human Neuregulin-1/NRG1 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with the EGF-like domains of recombinant human (rh) NRG1-beta 1 (aa 176-246) or rhNRG1-alpha (aa 177-241). Therefore, this antibody recognizes an epitope located within aa 2-176 segment N-terminal to the EGF-like domain. This segment is present in all NRG1-alpha , beta and gamma isoforms and in NDF43 and glial growth factor (GGF). It is absent from the NRG1 gene products GGF2 and SMDF.

gene symbol :

NRG1

catalog number base :

MAB377

accessionNumbers :

AAA58639

applications :

Western Blot

2020 USD :

339

2021 USD :

359 USD

alt names :

ARIA, GGF2, GGFglial growth factor, Heregulin-1, HGL, HGLneu differentiation factor, HRG, HRG1, HRG1-alpha, HRG1-beta 1, HRGAneuregulin 1 type IV beta 1a, MST131, MSTP131, NDFheregulin, alpha (45kD, ERBB2 p185-activator), neuregulin 1, neuregulin 1 type IV beta 3, Neuregulin1, NRG1, pro-neuregulin-1, membrane-bound isoform, pro-NRG1, sensory and motor neuron derived factor, SMDF

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.