Human TRAIL/TNFSF10 Antibody | R&D Systems MAB375-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TRAIL/TNFSF10 Antibody

catalog :

MAB375-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

75411

reactivity :

human, mouse

application :

ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 21

Reference
Yagolovich A, Isakova A, Artykov A, Vorontsova Y, Mazur D, Antipova N, et al. DR5-Selective TRAIL Variant DR5-B Functionalized with Tumor-Penetrating iRGD Peptide for Enhanced Antitumor Activity against Glioblastoma. Int J Mol Sci. 2022;23: pubmed publisher
Yagolovich A, Artykov A, Isakova A, Vorontsova Y, Dolgikh D, Kirpichnikov M, et al. Optimized Heterologous Expression and Efficient Purification of a New TRAIL-Based Antitumor Fusion Protein SRH-DR5-B with Dual VEGFR2 and DR5 Receptor Specificity. Int J Mol Sci. 2022;23: pubmed publisher
Rajaratnam N, Ditlevsen N, Sloth J, Bæk R, Jørgensen M, Christiansen O. Extracellular Vesicles: An Important Biomarker in Recurrent Pregnancy Loss?. J Clin Med. 2021;10: pubmed publisher
Wu G, Cheney C, Huang Q, Hazuda D, Howell B, Zuck P. Improved Detection of HIV Gag p24 Protein Using a Combined Immunoprecipitation and Digital ELISA Method. Front Microbiol. 2021;12:636703 pubmed publisher
Lalaoui N, Merino D, Giner G, Vaillant F, Chau D, Liu L, et al. Targeting triple-negative breast cancers with the Smac-mimetic birinapant. Cell Death Differ. 2020;27:2768-2780 pubmed publisher
Jørgensen M, Bæk R, Sloth J, Varming K, Christiansen O, Ditlevsen N, et al. Treatment with intravenous immunoglobulin increases the level of small EVs in plasma of pregnant women with recurrent pregnancy loss. J Reprod Immunol. 2020;140:103128 pubmed publisher
Arnold N, Pickworth J, West L, Dawson S, Carvalho J, Casbolt H, et al. A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. Nat Commun. 2019;10:5183 pubmed publisher
Vickman R, Yang J, Lanman N, Cresswell G, Zheng F, Zhang C, et al. Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNFα in Castration-Resistant Prostate Cancer. Mol Cancer Res. 2019;17:1253-1263 pubmed publisher
Brunetti G, Di Benedetto A, Posa F, Colaianni G, Faienza M, Ballini A, et al. High expression of TRAIL by osteoblastic differentiated dental pulp stem cells affects myeloma cell viability. Oncol Rep. 2018;39:2031-2039 pubmed publisher
Tanzer M, Khan N, Rickard J, Etemadi N, Lalaoui N, Spall S, et al. Combination of IAP antagonist and IFNÎ³ activates novel caspase-10- and RIPK1-dependent cell death pathways. Cell Death Differ. 2017;24:481-491 pubmed publisher
Radke D, Ungefroren H, Helm O, Voigt S, Alp G, Braun H, et al. Negative control of TRAIL-R1 signaling by transforming growth factor ?1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1. Cell Signal. 2016;28:1652-62 pubmed publisher
Singh S, Ajay A, Mohammad N, Malvi P, Chaube B, Meena A, et al. Proteasomal inhibition sensitizes cervical cancer cells to mitomycin C-induced bystander effect: the role of tumor microenvironment. Cell Death Dis. 2015;6:e1934 pubmed publisher
Robinet P, Baychelier F, Fontaine T, Picard C, Debre P, Vieillard V, et al. A polysaccharide virulence factor of a human fungal pathogen induces neutrophil apoptosis via NK cells. J Immunol. 2014;192:5332-42 pubmed publisher
Tel J, Smits E, Anguille S, Joshi R, Figdor C, de Vries I. Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities. Blood. 2012;120:3936-44 pubmed publisher
Kalb M, Glaser A, Stary G, Koszik F, Stingl G. TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-?-mediated antitumor reactivity. J Immunol. 2012;188:1583-91 pubmed publisher
Inglefield J, Dumitru C, Alkan S, Gibson S, Lipson K, Tomai M, et al. TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN. J Interferon Cytokine Res. 2008;28:253-63 pubmed publisher
Kavurma M, Schoppet M, Bobryshev Y, Khachigian L, Bennett M. TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappaB and induction of insulin-like growth factor-1 receptor. J Biol Chem. 2008;283:7754-62 pubmed publisher
Krysov S, Rowley T, Al Shamkhani A. Inhibition of p38 mitogen-activated protein kinase unmasks a CD30-triggered apoptotic pathway in anaplastic large cell lymphoma cells. Mol Cancer Ther. 2007;6:703-11 pubmed
Georgopoulos N, Steele L, Thomson M, Selby P, Southgate J, Trejdosiewicz L. A novel mechanism of CD40-induced apoptosis of carcinoma cells involving TRAF3 and JNK/AP-1 activation. Cell Death Differ. 2006;13:1789-801 pubmed
Brando C, Mukhopadhyay S, Kovacs E, Medina R, Patel P, Catina T, et al. Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104. J Leukoc Biol. 2005;78:359-71 pubmed
Armeanu S, Lauer U, Smirnow I, Schenk M, Weiss T, Gregor M, et al. Adenoviral gene transfer of tumor necrosis factor-related apoptosis-inducing ligand overcomes an impaired response of hepatoma cells but causes severe apoptosis in primary human hepatocytes. Cancer Res. 2003;63:2369-72 pubmed

product information

master code :

MAB375

SKU :

MAB375-100

product name :

Human TRAIL/TNFSF10 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human TRAIL/TNFSF10 Antibody from R&D Systems is a mouse monoclonal antibody to TRAIL/TNFSF10. This antibody reacts with human,mouse. The Human TRAIL/TNFSF10 Antibody has been validated for the following applications: Bioassay,ELISA (Capture),Neutralization,ELISA Capture,ELISA Detection,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry.

target :

TRAIL/TNFSF10

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

75411

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human TRAIL/TNFSF10, Thr95-Gly281, Accession # P50591

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human,Mouse

specificity :

Detects human TRAIL/TNFSF10 in direct ELISAs.

gene symbol :

TNFSF10

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Cytotoxicity Induced by TRAIL/TNFSF10 and Neutralization by Human TRAIL/TNFSF10 Antibody.

accessionNumbers :

P50591

applications :

Bioassay,ELISA (Capture),Neutralization,ELISA Capture,ELISA Detection,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry

USD :

489 USD

alt names :

Apo-2 ligand, APO2L, Apo-2Ltumor necrosis factor (ligand) family, member 10, APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta, CD253, CD253 antigen, Protein TRAIL, TL2, TNF-related apoptosis-inducing ligand, TNFSF10, TRAILTNF-related apoptosis inducing ligand TRAIL, tumor necrosis factor (ligand) superfamily, member 10, tumor necrosis factor ligand superfamily member 10

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage