product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human CX3CL1/Fractalkine Chemokine Domain Antibody
catalog :
MAB3652-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
81506
reactivity :
human
application :
western blot, ELISA, neutralization, flow cytometry
more info or order :
R&D Systems product webpage
citations: 10
Reference
Li J, Wuethrich A, Sina A, Cheng H, Wang Y, Behren A, et al. A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy. Nat Commun. 2021;12:1087 pubmed publisher
Brown M, Johnson L, Leone D, Májek P, Vaahtomeri K, Senfter D, et al. Lymphatic exosomes promote dendritic cell migration along guidance cues. J Cell Biol. 2018;217:2205-2221 pubmed publisher
Babendreyer A, Molls L, Dreymueller D, Uhlig S, Ludwig A. Shear Stress Counteracts Endothelial CX3CL1 Induction and Monocytic Cell Adhesion. Mediators Inflamm. 2017;2017:1515389 pubmed publisher
Quillinan N, Clark K, Youl B, Vernes J, McIntosh D, Haq S, et al. Multiplex serum protein analysis reveals potential mechanisms and markers of response to hyperimmune caprine serum in systemic sclerosis. Arthritis Res Ther. 2017;19:45 pubmed publisher
Kassianos A, Wang X, Sampangi S, Afrin S, Wilkinson R, Healy H. Fractalkine-CX3CR1-dependent recruitment and retention of human CD1c+ myeloid dendritic cells by in vitro-activated proximal tubular epithelial cells. Kidney Int. 2015;87:1153-63 pubmed publisher
Denoyer A, Godefroy D, Celerier I, Frugier J, Riancho L, Baudouin F, et al. CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation. Mucosal Immunol. 2012;5:702-11 pubmed publisher
Nevo I, Sagi Assif O, Meshel T, Ben Baruch A, Johrer K, Greil R, et al. The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells. Cancer Lett. 2009;273:127-39 pubmed publisher
Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet T. Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration. J Leukoc Biol. 2008;84:215-23 pubmed publisher
Hundhausen C, Schulte A, Schulz B, Andrzejewski M, Schwarz N, von Hundelshausen P, et al. Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes. J Immunol. 2007;178:8064-72 pubmed
Lavergne E, Combadiere B, Bonduelle O, Iga M, Gao J, Maho M, et al. Fractalkine mediates natural killer-dependent antitumor responses in vivo. Cancer Res. 2003;63:7468-74 pubmed
product information
master code :
MAB3652
SKU :
MAB3652-100
product name :
Human CX3CL1/Fractalkine Chemokine Domain Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human CX3CL1/Fractalkine Chemokine Domain Antibody from R&D Systems is a mouse monoclonal antibody to CX3CL1/Fractalkine. This antibody reacts with human. The Human CX3CL1/Fractalkine Chemokine Domain Antibody has been validated for the following applications: ELISA Development,ELISA Development (Capture),Flow Cytometry,Western Blot,Neutralization,Functional Assay,ELISA Capture (Matched Antibody Pair),Intracellular Staining by Flow Cytometry,CyTOF-ready.
target :
CX3CL1/Fractalkine
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
81506
conjugate :
Unconjugated
host :
Mouse
immunogen :
NS0-derived and E. coli -derived Recombinant Human CX3CL1/Fracktalkine, Gln25-Arg339, Accession # P78423
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human CX3CL1/Fractalkine in ELISAs. In sandwich immunoassays, less than 10% cross-reactivity with recombinant mouse CXCL6 and less than 0.2% cross-reactivity with recombinant human (rh) CXCL6, rhCXCL9, and recombinant rat CX3CL1 is observed.
gene symbol :
CX3CL1
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Chemotaxis Induced by CX3CL1/Fractalkine and Neutralization by Human CX3CL1/Fractalkine Antibody.
accessionNumbers :
P78423
applications :
ELISA Development,ELISA Development (Capture),Flow Cytometry,Western Blot,Neutralization,Functional Assay,ELISA Capture (Matched Antibody Pair),Intracellular Staining by Flow Cytometry,CyTOF-ready
USD :
469 USD
alt names :
ABCD-3, C3Xkine, chemokine (C-X3-C motif) ligand 1, CX3C membrane-anchored chemokine, CXC3, CXC3C, FKN, fractalkine, Neurotactin, neurotactin), NTNsmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, NTTSmall-inducible cytokine D1, SCYD1C-X3-C motif chemokine 1, small inducible cytokine subfamily D (Cys-X3-Cys), member-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.