product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human CX3CL1/Fractalkine Chemokine Domain Antibody
catalog :
MAB365-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
459 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
51637
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 12
Reference
Tsai W, Chang S, Lin Y, Hsu H. CX3CL1(+) Microparticles-Induced MFG-E8 Enhances Apoptotic Cell Clearance by Alveolar Macrophages. Cells. 2021;10: pubmed publisher
Babendreyer A, Molls L, Dreymueller D, Uhlig S, Ludwig A. Shear Stress Counteracts Endothelial CX3CL1 Induction and Monocytic Cell Adhesion. Mediators Inflamm. 2017;2017:1515389 pubmed publisher
Tsai W, Shih C, Feng S, Li I, Chang S, Lin Y, et al. CX3CL1(+) microparticles mediate the chemoattraction of alveolar macrophages toward apoptotic acute promyelocytic leukemic cells. Cell Physiol Biochem. 2014;33:594-604 pubmed publisher
Gordon J, Sariyer I, de la Fuente Granada M, Augelli B, Otte J, Azizi S, et al. Neural Crest Cells Isolated from the Bone Marrow of Transgenic Mice Express JCV T-Antigen. PLoS ONE. 2013;8:e65947 pubmed publisher
Fujita M, Takada Y, Takada Y. Integrins ?v?3 and ?4?1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1. J Immunol. 2012;189:5809-19 pubmed publisher
Suzuki F, Kubota T, Miyazaki Y, Ishikawa K, Ebisawa M, Hirohata S, et al. Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity. Arthritis Res Ther. 2012;14:R48 pubmed publisher
Truman L, Ford C, Pasikowska M, Pound J, Wilkinson S, Dumitriu I, et al. CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood. 2008;112:5026-36 pubmed publisher
Dame T, Orenzoff B, Palmer L, Furie M. IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation. J Immunol. 2007;178:1172-9 pubmed
Faure V, Cerini C, Paul P, Berland Y, Dignat George F, Brunet P. The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro. Int Immunol. 2006;18:1453-9 pubmed
Deiva K, Geeraerts T, Salim H, Leclerc P, Hery C, Hugel B, et al. Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. Eur J Neurosci. 2004;20:3222-32 pubmed
Chazaud B, Sonnet C, Lafuste P, Bassez G, Rimaniol A, Poron F, et al. Satellite cells attract monocytes and use macrophages as a support to escape apoptosis and enhance muscle growth. J Cell Biol. 2003;163:1133-43 pubmed
Lucas A, Chadwick N, Warren B, Jewell D, Gordon S, Powrie F, et al. The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo. Am J Pathol. 2001;158:855-66 pubmed
product information
master code :
MAB365
SKU :
MAB365-100
product name :
Human CX3CL1/Fractalkine Chemokine Domain Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human CX3CL1/Fractalkine Chemokine Domain Antibody from R&D Systems is a mouse monoclonal antibody to CX3CL1/Fractalkine. This antibody reacts with human. The Human CX3CL1/Fractalkine Chemokine Domain Antibody has been validated for the following applications: Cell-based ELISA,Flow Cytometry,Western Blot,Neutralization,Functional Assay,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry,Intracellular Staining by Flow Cytometry,CyTOF-ready.
target :
CX3CL1/Fractalkine
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
51637
conjugate :
Unconjugated
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human CX3CL1/Fractalkine Chemokine Domain, Gln25-Arg339 (Ser199Asn) (predicted), Accession # P78423
isotype :
IgG1
purity :
Protein A or G purified from ascites
species :
Human
specificity :
Detects human CX3CL1/Fractalkine Chemokine Domain in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse CX3CL1 or recombinant rat CX3CL1 is observed.
gene symbol :
CX3CL1
accessionNumbers :
P78423
applications :
Cell-based ELISA,Flow Cytometry,Western Blot,Neutralization,Functional Assay,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry,Intracellular Staining by Flow Cytometry,CyTOF-ready
USD :
459 USD
alt names :
ABCD-3, C3Xkine, chemokine (C-X3-C motif) ligand 1, CX3C membrane-anchored chemokine, CXC3, CXC3C, FKN, fractalkine, Neurotactin, neurotactin), NTNsmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, NTTSmall-inducible cytokine D1, SCYD1C-X3-C motif chemokine 1, small inducible cytokine subfamily D (Cys-X3-Cys), member-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.