Human VEGFR2/KDR/Flk-1 Antibody | R&D Systems MAB3572 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human VEGFR2/KDR/Flk-1 Antibody

catalog :

MAB3572

quantity :

100 ug (also 25 ug, 500 ug)

price :

359 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

89106

reactivity :

human

application :

neutralization, flow cytometry, blocking or activating experiments

citations: 21

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; tbl 1	Monsuur H, Weijers E, Niessen F, Gefen A, Koolwijk P, Gibbs S, et al. Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering. PLoS ONE. 2016;11:e0167056 pubmed publisher
blocking or activating experiments; human	Arnott C, Punnia Moorthy G, Tan J, Sadeghipour S, Bursill C, Patel S. The Vascular Endothelial Growth Factor Inhibitors Ranibizumab and Aflibercept Markedly Increase Expression of Atherosclerosis-Associated Inflammatory Mediators on Vascular Endothelial Cells. PLoS ONE. 2016;11:e0150688 pubmed publisher
flow cytometry; human; 1:100; fig 2g	Abe S, Yamaguchi S, Sato Y, Harada K. Sphere-Derived Multipotent Progenitor Cells Obtained From Human Oral Mucosa Are Enriched in Neural Crest Cells. Stem Cells Transl Med. 2016;5:117-28 pubmed publisher
	Tamari T, Kawar Jaraisy R, Doppelt O, Giladi B, Sabbah N, Zigdon Giladi H. The Paracrine Role of Endothelial Cells in Bone Formation via CXCR4/SDF-1 Pathway. Cells. 2020;9: pubmed publisher
	Koehler L, Ruiz Gómez G, Balamurugan K, Rother S, Freyse J, Moller S, et al. Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A. Sci Rep. 2019;9:18143 pubmed publisher
	Toledo Pons N, Noell G, Jahn A, Iglesias A, Durán M, Iglesias J, et al. Bone marrow characterization in COPD: a multi-level network analysis. Respir Res. 2018;19:118 pubmed publisher
	Odent Grigorescu G, Rosca A, Preda M, Tutuianu R, Simionescu M, Burlacu A. Synergic effects of VEGF-A and SDF-1 on the angiogenic properties of endothelial progenitor cells. J Tissue Eng Regen Med. 2017;11:3241-3252 pubmed publisher
	Silva I, Salhi A, Giles K, Vogelsang M, Han S, Ismaili N, et al. Identification of a Novel Pathogenic Germline KDR Variant in Melanoma. Clin Cancer Res. 2016;22:2377-85 pubmed publisher
	Jarajapu Y, Hazra S, Segal M, Li Calzi S, LiCalzi S, Jadhao C, et al. Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms. PLoS ONE. 2014;9:e93965 pubmed publisher
	Goretti E, Rolland Turner M, Léonard F, Zhang L, Wagner D, Devaux Y. MicroRNA-16 affects key functions of human endothelial progenitor cells. J Leukoc Biol. 2013;93:645-55 pubmed publisher
	Facciabene A, Peng X, Hagemann I, Balint K, Barchetti A, Wang L, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature. 2011;475:226-30 pubmed publisher
	Byeon S, Lee S, Choi S, Lee H, Lee J, Chu Y, et al. Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/Akt. Invest Ophthalmol Vis Sci. 2010;51:1190-7 pubmed publisher
	Riccioni R, Senese M, Diverio D, Riti V, Mariani G, Boe A, et al. Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels. Leuk Res. 2008;32:1244-58 pubmed publisher
	Ohsaka A, Hirota Komatsu S, Shibata M, Ezaki J, Shinohara F, Yoshida T. Specific association of increased vascular endothelial growth factor expression and its receptors with macrophage differentiation of HL-60 leukemia cells. Biochem Biophys Res Commun. 2008;368:543-9 pubmed publisher
	Lin Y, Liang Y, Chiang B. Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. J Leukoc Biol. 2007;82:1473-80 pubmed
	Ball S, Shuttleworth C, Kielty C. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J Cell Biol. 2007;177:489-500 pubmed
	Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, et al. Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. Stem Cells. 2007;25:1862-71 pubmed
	Rajesh D, Chinnasamy N, Mitalipov S, Wolf D, Slukvin I, Thomson J, et al. Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells. 2007;25:490-9 pubmed
	Caldas H, Fangusaro J, Boue D, Holloway M, Altura R. Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis. Blood. 2007;109:1479-89 pubmed
	Sreekumar P, Kannan R, de Silva A, Burton R, Ryan S, Hinton D. Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells. Biochem Biophys Res Commun. 2006;346:1200-6 pubmed
	Hirakawa S, Kodama S, Kunstfeld R, Kajiya K, Brown L, Detmar M. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med. 2005;201:1089-99 pubmed

product information

brand :

R&D Systems

master code :

MAB3572

SKU :

MAB3572-100

product name :

Human VEGFR2/KDR/Flk-1 Antibody

description :

The Human VEGFR2/KDR/Flk-1 Antibody from R&D Systems is a mouse monoclonal antibody to VEGFR2/KDR/Flk-1. This antibody reacts with human. The Human VEGFR2/KDR/Flk-1 Antibody has been validated for the following applications: Flow Cytometry, Neutralization, CyTOF-ready.

target :

VEGFR2/KDR/Flk-1

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

89106

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human VEGFR2/KDR/Flk-1, Ala20-Glu764, Accession # P35968

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human VEGFR2/KDR/Flk-1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) VEGFR1, rhVEGFR3 or recombinant mouse VEGFR2 is observed.

gene symbol :

KDR

details of functionality :

ActivityAssaywCitation not found None None

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB3572

accessionNumbers :

P35968

applications :

Flow Cytometry, Neutralization, CyTOF-ready

2020 USD :

339

2021 USD :

359 USD

alt names :

CD309, CD309 antigen, EC 2.7.10, EC 2.7.10.1, Fetal liver kinase 1, fetal liver kinase-1, Flk1, Flk-1, FLK1tyrosine kinase growth factor receptor, KDR, Kinase insert domain receptor, kinase insert domain receptor (a type III receptor tyrosine kinase), KRD1, Ly73, Protein-tyrosine kinase receptor flk-1, soluble VEGFR2, vascular endothelial growth factor receptor 2, VEGF R2, VEGFR, VEGFR2, VEGFR-2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.