Human BMP-2/BMP-4 Antibody | R&D Systems MAB3552-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human BMP-2/BMP-4 Antibody

catalog :

MAB3552-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

100230

reactivity :

human, mouse, chicken

application :

western blot, immunohistochemistry, neutralization, immunoprecipitation, blocking or activating experiments

more info or order :

R&D Systems product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 2 ug/ml; loading ...; fig 4f	Chen W, Foo S, Hong E, Wu C, Lee W, Lee S, et al. Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses. Nat Microbiol. 2021;6:455-466 pubmed publisher
	Nagel S, Pommerenke C, Meyer C, MacLeod R. The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia. Int J Mol Sci. 2022;23: pubmed publisher
	Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. elife. 2020;9: pubmed publisher
	Canali S, Wang C, Zumbrennen Bullough K, Bayer A, Babitt J. Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6. Am J Hematol. 2017;92:1204-1213 pubmed publisher
	Wang C, Core A, Canali S, Zumbrennen Bullough K, Ozer S, Umans L, et al. Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice. Blood. 2017;130:73-83 pubmed publisher
	MartÃnez V, SacedÃ³n R, Hidalgo L, Valencia J, FernÃ¡ndez Sevilla L, HernÃ¡ndez LÃ³pez C, et al. The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis. PLoS ONE. 2015;10:e0131453 pubmed publisher
	Boswell B, Musil L. Synergistic interaction between the fibroblast growth factor and bone morphogenetic protein signaling pathways in lens cells. Mol Biol Cell. 2015;26:2561-72 pubmed publisher
	Hamilton P, Jansen M, Ganesan S, Benson R, Hyde Deruyscher R, Beyer W, et al. Improved bone morphogenetic protein-2 retention in an injectable collagen matrix using bifunctional peptides. PLoS ONE. 2013;8:e70715 pubmed publisher
	Kramann R, Couson S, Neuss S, Kunter U, Bovi M, Bornemann J, et al. Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells. Arterioscler Thromb Vasc Biol. 2011;31:e45-54 pubmed publisher
	Stefanovic S, Abboud N, Désilets S, Nury D, Cowan C, Puceat M. Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol. 2009;186:665-73 pubmed publisher
	Boswell B, Overbeek P, Musil L. Essential role of BMPs in FGF-induced secondary lens fiber differentiation. Dev Biol. 2008;324:202-12 pubmed publisher
	Southwood M, Jeffery T, Yang X, Upton P, Hall S, Atkinson C, et al. Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J Pathol. 2008;214:85-95 pubmed
	Lin L, Valore E, Nemeth E, Goodnough J, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007;110:2182-9 pubmed
	Rydziel S, Stadmeyer L, Zanotti S, Durant D, Smerdel Ramoya A, Canalis E. Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. J Biol Chem. 2007;282:19762-72 pubmed
	Zhao M, Zhao Z, Koh J, Jin T, Franceschi R. Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7. J Cell Biochem. 2005;95:1-16 pubmed

product information

master code :

MAB3552

SKU :

MAB3552-100

product name :

Human BMP-2/BMP-4 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human BMP-2/BMP-4 Antibody from R&D Systems is a mouse monoclonal antibody to BMP-2/BMP-4. This antibody reacts with avian - chicken,human,mouse,transgenic mouse. The Human BMP-2/BMP-4 Antibody has been validated for the following applications: Neutralization,Bioassay,Immunoprecipitation,Western Blot,Cell Culture,Immunohistochemistry.

target :

BMP-2/BMP-4

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

100230

conjugate :

Unconjugated

host :

Mouse

immunogen :

Chinese hamster ovary cell line CHO-derived recombinant human BMP-2, Gln283-Arg396, Accession # P12643

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Avian - Chicken,Human,Mouse

specificity :

Detects human BMP-2 and human BMP-4 in direct ELISAs and Western blots. In direct ELISAs, 100% cross-reactivity with recombinant zebra fish (rzf) BMP-2 and rhBMP-4, 20%-40% cross-reactivity with rhBMP-3, -3b, -6, and no cross-reactivity with rhBMP-5, -7, -10, or -15 is observed.

gene symbol :

BMP2

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Alkaline Phosphatase Production Induced by BMP-2 and Neutralization by Human BMP-2/BMP-4 Antibody.

accessionNumbers :

P12643

applications :

Bioassay,Immunoprecipitation,Western Blot,Neutralization,Cell Culture,Immunohistochemistry

USD :

469 USD

alt names :

BDA2, BMP2, BMP-2, BMP2A, BMP-2A, BMP2ABone morphogenetic protein 2A, BMP2B, BMP2B1, BMP4, bone morphogenetic protein 2, MCOPS6, OFC11, SSFSC

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage