Human BMP-2 Antibody | R&D Systems MAB3551-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human BMP-2 Antibody

catalog :

MAB3551-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

100221

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 14

Reference
Grotheer V, Skrynecki N, Oezel L, Windolf J, Grassmann J. Osteogenic differentiation of human mesenchymal stromal cells and fibroblasts differs depending on tissue origin and replicative senescence. Sci Rep. 2021;11:11968 pubmed publisher
Kim M, Kim C, Kim Y, Jang J, Lee G. Selective endocytosis of recombinant human BMPs through cell surface heparan sulfate proteoglycans in CHO cells: BMP-2 and BMP-7. Sci Rep. 2021;11:3378 pubmed publisher
Cheng Z, Alba Perez A, González García C, Donnelly H, Llopis Hernández V, Jayawarna V, et al. Nanoscale Coatings for Ultralow Dose BMP-2-Driven Regeneration of Critical-Sized Bone Defects. Adv Sci (Weinh). 2019;6:1800361 pubmed publisher
Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
Chang C, Yeh S, Lee B, Chen C, Su C, Lin Y, et al. Osteogenic Surface Modification Based on Functionalized Poly-P-Xylylene Coating. PLoS ONE. 2015;10:e0137017 pubmed publisher
Lowery J, Amich J, Andonian A, Rosen V. N-linked glycosylation of the bone morphogenetic protein receptor type 2 (BMPR2) enhances ligand binding. Cell Mol Life Sci. 2014;71:3165-72 pubmed publisher
Sharma A, Meyer F, Hyvonen M, Best S, Cameron R, Rushton N. Osteoinduction by combining bone morphogenetic protein (BMP)-2 with a bioactive novel nanocomposite. Bone Joint Res. 2012;1:145-51 pubmed publisher
Du Y, Xiao Q, Yip H. Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade. Invest Ophthalmol Vis Sci. 2010;51:3764-73 pubmed publisher
Chen Y, Chen P, Jeng L, Huang C, Yang L, Chung H, et al. Periodontal regeneration using ex vivo autologous stem cells engineered to express the BMP-2 gene: an alternative to alveolaplasty. Gene Ther. 2008;15:1469-77 pubmed publisher
Kane R, Godson C, O Brien C. Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Mol Vis. 2008;14:1138-48 pubmed
Sengle G, Charbonneau N, Ono R, Sasaki T, Alvarez J, Keene D, et al. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008;283:13874-88 pubmed publisher
Kuns Hashimoto R, Kuninger D, Nili M, Rotwein P. Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin. Am J Physiol Cell Physiol. 2008;294:C994-C1003 pubmed publisher
Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller E. Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism. Cancer Res. 2005;65:8274-85 pubmed
Kayed H, Kleeff J, Keleg S, Guo J, Ketterer K, Berberat P, et al. Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer. Int J Cancer. 2004;110:668-76 pubmed

product information

brand :

R&D Systems

master code :

MAB3551

SKU :

MAB3551-100

product name :

Human BMP-2 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human BMP-2 Antibody from R&D Systems is a mouse monoclonal antibody to BMP-2. This antibody reacts with hamster,human,mouse,primate - chlorocebus pygerythrus (vervet monkey),rabbit. The Human BMP-2 Antibody has been validated for the following applications: Bioassay,Immunoprecipitation,Western Blot,Neutralization,Immunohistochemistry,Immunocytochemistry,ELISA Capture (Matched Antibody Pair).

target :

BMP-2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

100221

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL

host :

Mouse

immunogen :

Chinese hamster ovary cell line CHO-derived recombinant human BMP-2, Gln283-Arg396, Accession # P12643

isotype :

IgG2b

purity :

Protein A or G purified from ascites

species :

Hamster,Human,Mouse,Primate - Chlorocebus pygerythrus (Vervet Monkey),Rabbit

specificity :

Detects human BMP-2 in ELISAs and Western blots. In Western blots, this antibody shows less than 1% cross-reactivity with recombinant human (rh) BMP-3, rhBMP-4, rhBMP-5, rhBMP-6, or rhBMP-7.

gene symbol :

BMP2

accessionNumbers :

P12643

applications :

ELISA Capture (Matched Antibody Pair),Bioassay,Immunohistochemistry,Immunoprecipitation,Western Blot,Neutralization,Immunocytochemistry

USD :

469 USD

alt names :

BDA2, BMP2, BMP-2, BMP-2A, BMP2ABone morphogenetic protein 2A, bone morphogenetic protein 2, SSFSC

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage