Human/Mouse CXCL12/SDF-1 Antibody | R&D Systems MAB350 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse CXCL12/SDF-1 Antibody

catalog :

MAB350

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

79018

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 80

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 10 ug/ml; loading ...; fig 1	Zheng J, Qu D, Wang C, Ding L, Zhou W. Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling. BMC Pregnancy Childbirth. 2020;20:87 pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig 3b	Atif S, Mack D, McKee A, Rangel Moreno J, Martin A, Getahun A, et al. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019;5: pubmed publisher
immunohistochemistry - paraffin section; human; 1:250	Rickelt S, Hynes R. Antibodies and methods for immunohistochemistry of extracellular matrix proteins. Matrix Biol. 2018;71-72:10-27 pubmed publisher
immunohistochemistry - paraffin section; rat; 1:40; loading ...; fig st14	Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
immunohistochemistry - frozen section; human; loading ...; fig 4	Ujiie I, Fujita Y, Nakayama C, Matsumura W, Suzuki S, Shinkuma S, et al. Altered balance of epidermis-related chemokines in epidermolysis bullosa. J Dermatol Sci. 2017;86:37-45 pubmed publisher
flow cytometry; human; loading ...; fig 2d	Pangrazzi L, Meryk A, Naismith E, Koziel R, Lair J, Krismer M, et al. "Inflamm-aging" influences immune cell survival factors in human bone marrow. Eur J Immunol. 2017;47:481-492 pubmed publisher
	Tsai C, Yu S, Lee C, Pang J, Wu C, Lin S, et al. SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo. Oncogene. 2020;39:4695-4710 pubmed publisher
	Baci D, Bruno A, Cascini C, Gallazzi M, Mortara L, Sessa F, et al. Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies. J Exp Clin Cancer Res. 2019;38:464 pubmed publisher
	Liu X, Tonello R, Ling Y, Gao Y, Berta T. Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1. J Neuroinflammation. 2019;16:209 pubmed publisher
	Kalpana G, Figy C, Yeung M, Yeung K. Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling. Sci Rep. 2019;9:16351 pubmed publisher
	Pansy K, Feichtinger J, Ehall B, Uhl B, Sedej M, Roula D, et al. The CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In Vitro. Int J Mol Sci. 2019;20: pubmed publisher
	Lee G, Jeong S, Lee H, Oh I. Age-related differences in the bone marrow stem cell niche generate specialized microenvironments for the distinct regulation of normal hematopoietic and leukemia stem cells. Sci Rep. 2019;9:1007 pubmed publisher
	Wang M, Yang X, Wei M, Wang Z. The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer. J Cancer. 2018;9:3898-3903 pubmed publisher
	Yoon J, Kim Y, Kwon S, Kim M, Kim Y, Kim J, et al. Senescent fibroblasts drive ageing pigmentation: A potential therapeutic target for senile lentigo. Theranostics. 2018;8:4620-4632 pubmed publisher
	Marques C, Santos A, Gameiro A, Correia J, Ferreira F. CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors. BMC Cancer. 2018;18:741 pubmed publisher
	Raschioni C, Bottai G, Sagona A, Errico V, Testori A, Gatzemeier W, et al. CXCR4/CXCL12 Signaling and Protumor Macrophages in Primary Tumors and Sentinel Lymph Nodes Are Involved in Luminal B Breast Cancer Progression. Dis Markers. 2018;2018:5018671 pubmed publisher
	Baci D, Bruno A, Bassani B, Tramacere M, Mortara L, Albini A, et al. Acetyl-l-carnitine is an anti-angiogenic agent targeting the VEGFR2 and CXCR4 pathways. Cancer Lett. 2018;429:100-116 pubmed publisher
	Chau M, Deveau T, Gu X, Kim Y, Xu Y, Yu S, et al. Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice. BMC Neurosci. 2018;19:20 pubmed publisher
	Kitawaki Y, Nakamura Y, Kubota Nakayama F, Yamazaki Y, Miki Y, Hata S, et al. Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. Hum Pathol. 2018;77:88-97 pubmed publisher
	Tang W, Chen Y, Wang X, Chen Y, Zhang J, Lin Z. Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema. Oncol Lett. 2018;15:2501-2507 pubmed publisher
	Zhang J, Liu C, Mo X, Shi H, Li S. Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer. Oncol Lett. 2018;15:1771-1776 pubmed publisher
	Venkatesh A, Nandigam H, Muccioli M, Singh M, Loftus T, Lewis D, et al. Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells. Immunobiology. 2018;223:466-476 pubmed publisher
	De Colle C, Mönnich D, Welz S, Boeke S, Sipos B, Fend F, et al. SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy. Clin Transl Radiat Oncol. 2017;5:28-36 pubmed publisher
	Pollok K, Mothes R, Ulbricht C, Liebheit A, Gerken J, Uhlmann S, et al. The chronically inflamed central nervous system provides niches for long-lived plasma cells. Acta Neuropathol Commun. 2017;5:88 pubmed publisher
	Omland S, Wettergren E, Mollerup S, Asplund M, Mourier T, Hansen A, et al. Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin. BMC Cancer. 2017;17:675 pubmed publisher
	Zboralski D, Hoehlig K, Eulberg D, Frömming A, Vater A. Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade. Cancer Immunol Res. 2017;5:950-956 pubmed publisher
	McClendon J, Jansing N, Redente E, Gandjeva A, Ito Y, Colgan S, et al. Hypoxia-Inducible Factor 1? Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury. Am J Pathol. 2017;187:1772-1786 pubmed publisher
	Lovshin J, Rajasekeran H, Lytvyn Y, Lovblom L, Khan S, Alemu R, et al. Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1Î±1-67 in Patients With Type 2 Diabetes. Diabetes Care. 2017;40:1073-1081 pubmed publisher
	Bromage D, Taferner S, Pillai M, Yellon D, Davidson S. A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies. PLoS ONE. 2017;12:e0174447 pubmed publisher
	Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, et al. Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. EMBO J. 2017;36:840-853 pubmed publisher
	Pierce H, Zhang D, Magnon C, Lucas D, Christin J, Huggins M, et al. Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay. Cell Stem Cell. 2017;20:648-658.e4 pubmed publisher
	Zhu X, Bai Q, Lu Y, Lu Y, Zhu L, Zhou X, et al. Expression and function of CXCL12/CXCR4/CXCR7 in thyroid cancer. Int J Oncol. 2016;48:2321-9 pubmed publisher
	Siddiqi F, Chen L, Advani S, Thai K, Batchu S, Alghamdi T, et al. CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney. Endocrinology. 2015;156:1121-32 pubmed publisher
	Sangaletti S, Tripodo C, Portararo P, Dugo M, Vitali C, Botti L, et al. Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies. Oncoimmunology. 2014;3:e28989 pubmed
	Batsi O, Giannopoulou I, Nesseris I, Valavanis C, Gakiopoulou H, Patsouris E, et al. Immunohistochemical evaluation of CXCL12-CXCR4 axis and VEGFR3 expression in primary urothelial cancer and its recurrence. Anticancer Res. 2014;34:3537-42 pubmed
	Hu W, Liu Y, Zhou W, Si L, Ren L. CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro. PLoS ONE. 2014;9:e99056 pubmed publisher
	Geherin S, Wilson R, Jennrich S, Debes G. CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph. PLoS ONE. 2014;9:e95626 pubmed publisher
	Zhang W, He L, Shi X, Wu S, Zhang B, Mei L, et al. Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease. Respir Res. 2014;15:33 pubmed publisher
	Chen L, Advani S, Thai K, Kabir M, Sood M, Gibson I, et al. SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease. PLoS ONE. 2014;9:e92227 pubmed publisher
	Roy I, Zimmerman N, Mackinnon A, Tsai S, Evans D, Dwinell M. CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. PLoS ONE. 2014;9:e90400 pubmed publisher
	Pinto S, Martinez Romero A, O Connor J, Gil Benso R, San Miguel T, Terrádez L, et al. Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation. BMC Cancer. 2014;14:118 pubmed publisher
	Walters M, Ebsworth K, Berahovich R, Penfold M, Liu S, Al Omran R, et al. Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats. Br J Cancer. 2014;110:1179-88 pubmed publisher
	D Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, et al. A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients. Int J Cancer. 2014;135:379-90 pubmed publisher
	Klink B, Miletic H, Stieber D, Huszthy P, Campos Valenzuela J, Valenzuela J, et al. A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1. PLoS ONE. 2013;8:e59773 pubmed publisher
	Akhtar S, Gremse F, Kiessling F, Weber C, Schober A. CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice. Arterioscler Thromb Vasc Biol. 2013;33:679-86 pubmed publisher
	Liberman J, Sartelet H, Flahaut M, Mühlethaler Mottet A, Coulon A, Nyalendo C, et al. Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma. PLoS ONE. 2012;7:e43665 pubmed publisher
	Kayali A, Lopez A, Hao E, Hinton A, Hayek A, King C. The SDF-1?/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells. PLoS ONE. 2012;7:e38721 pubmed publisher
	Kulbe H, Chakravarty P, Leinster D, Charles K, Kwong J, Thompson R, et al. A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. Cancer Res. 2012;72:66-75 pubmed publisher
	Roy H, Bhardwaj S, Babu M, Lähteenvuo J, Yla Herttuala S. VEGF-DdeltaNdeltaC mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits. Eur J Clin Invest. 2010;40:422-32 pubmed publisher
	Eberlein J, Nguyen T, Victorino F, Golden Mason L, Rosen H, Homann D. Comprehensive assessment of chemokine expression profiles by flow cytometry. J Clin Invest. 2010;120:907-23 pubmed publisher
	Sayyed S, Hägele H, Kulkarni O, Endlich K, Segerer S, Eulberg D, et al. Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes. Diabetologia. 2009;52:2445-54 pubmed publisher
	Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur J, Hollenberg M, et al. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J. 2009;23:2928-41 pubmed publisher
	Diamond P, Labrinidis A, Martin S, Farrugia A, Gronthos S, To L, et al. Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss. J Bone Miner Res. 2009;24:1150-61 pubmed publisher
	Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, et al. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J Exp Med. 2009;206:249-58 pubmed publisher
	Struyf S, Noppen S, Loos T, Mortier A, Gouwy M, Verbeke H, et al. Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4. J Immunol. 2009;182:666-74 pubmed
	Gilbert D, Chandler I, McIntyre A, Goddard N, Gabe R, Huddart R, et al. Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents. J Pathol. 2009;217:94-102 pubmed publisher
	Biancotto A, Iglehart S, Lisco A, Vanpouille C, Grivel J, Lurain N, et al. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res Hum Retroviruses. 2008;24:453-62 pubmed publisher
	Struckmann K, Mertz K, Steu S, Storz M, Staller P, Krek W, et al. pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma. J Pathol. 2008;214:464-71 pubmed publisher
	Kleinman M, Greives M, Churgin S, Blechman K, Chang E, Ceradini D, et al. Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma. Arterioscler Thromb Vasc Biol. 2007;27:2664-70 pubmed
	Petty J, Sueblinvong V, Lenox C, Jones C, Cosgrove G, Cool C, et al. Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury. J Immunol. 2007;178:8148-57 pubmed
	Grivel J, Elliott J, Lisco A, Biancotto A, Condack C, Shattock R, et al. HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS. 2007;21:1263-72 pubmed
	Biancotto A, Grivel J, Iglehart S, Vanpouille C, Lisco A, Sieg S, et al. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood. 2007;109:4272-9 pubmed
	Tait L, Pauley R, Santner S, Heppner G, Heng H, Rak J, et al. Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts. Int J Cancer. 2007;120:2127-34 pubmed
	Peng H, Erdmann N, Whitney N, Dou H, Gorantla S, Gendelman H, et al. HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta. Glia. 2006;54:619-29 pubmed
	Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, et al. Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF. Cardiovasc Res. 2006;71:455-65 pubmed
	Marchal Sommé J, Uzunhan Y, Marchand Adam S, Valeyre D, Soumelis V, Crestani B, et al. Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis. J Immunol. 2006;176:5735-9 pubmed
	Massberg S, Konrad I, Schürzinger K, Lorenz M, Schneider S, Zohlnhoefer D, et al. Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med. 2006;203:1221-33 pubmed
	Yasumoto K, Koizumi K, Kawashima A, Saitoh Y, Arita Y, Shinohara K, et al. Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res. 2006;66:2181-7 pubmed
	Infantino S, Moepps B, Thelen M. Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. J Immunol. 2006;176:2197-207 pubmed
	Jung Y, Wang J, Schneider A, Sun Y, Koh Paige A, Osman N, et al. Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing. Bone. 2006;38:497-508 pubmed
	Lisignoli G, Cristino S, Piacentini A, Cavallo C, Caplan A, Facchini A. Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54. J Cell Physiol. 2006;207:364-73 pubmed
	Narducci M, Scala E, Bresin A, Caprini E, Picchio M, Remotti D, et al. Skin homing of Sézary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV. Blood. 2006;107:1108-15 pubmed
	Tanaka K, Sata M, Fukuda D, Suematsu Y, Motomura N, Takamoto S, et al. Age-associated aortic stenosis in apolipoprotein E-deficient mice. J Am Coll Cardiol. 2005;46:134-41 pubmed
	Liao T, Yurgelun M, Chang S, Zhang H, Murakami K, Blaine T, et al. Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone. J Orthop Res. 2005;23:203-9 pubmed
	Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
	Misslitz A, Pabst O, Hintzen G, Ohl L, Kremmer E, Petrie H, et al. Thymic T cell development and progenitor localization depend on CCR7. J Exp Med. 2004;200:481-91 pubmed
	Wald O, Pappo O, Safadi R, Dagan Berger M, Beider K, Wald H, et al. Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus. Eur J Immunol. 2004;34:1164-74 pubmed
	Levesque J, Liu F, Simmons P, Betsuyaku T, Senior R, Pham C, et al. Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood. 2004;104:65-72 pubmed
	Ueda Y, Yang K, Foster S, Kondo M, Kelsoe G. Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. J Exp Med. 2004;199:47-58 pubmed
	Villalba S, Salvucci O, Aoki Y, De La Luz Sierra M, Gupta G, Davis D, et al. Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo. J Leukoc Biol. 2003;74:880-8 pubmed

product information

brand :

R&D Systems

master code :

MAB350

SKU :

MAB350-100

product name :

Human/Mouse CXCL12/SDF-1 Antibody

description :

The Human/Mouse CXCL12/SDF-1 Antibody from R&D Systems is a mouse monoclonal antibody to CXCL12/SDF-1. This antibody reacts with human, mouse. The Human/Mouse CXCL12/SDF-1 Antibody has been validated for the following applications: Immunohistochemistry, Intracellular Staining by Flow Cytometry, Immunocytochemistry, CyTOF-ready, Dual RNAscope ISH-IHC, ELISA Capture (Matched Antibody Pair), ELISA Capture (Matched Antibody Pair).

target :

CXCL12/SDF-1

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

79018

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human CXCL12/SDF-1 alpha , Lys22-Lys89, Accession # Q6ICW0

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human, Mouse

specificity :

Detects human and mouse CXCL12/SDF-1 alpha and CXCL12/SDF-1 beta in ELISAs.

gene symbol :

CXCL12

details of functionality :

ActivityAssaywCitation not found None None None None None

catalog number base :

MAB350

accessionNumbers :

Q6ICW0

applications :

Immunohistochemistry, Intracellular Staining by Flow Cytometry, Immunocytochemistry, CyTOF-ready, Dual RNAscope ISH-IHC, ELISA Capture (Matched Antibody Pair), ELISA Capture (Matched Antibody Pair)

2020 USD :

339

2021 USD :

369 USD

alt names :

chemokine (C-X-C motif) ligand 12, C-X-C motif chemokine 12, hIRH, hSDF-1, Intercrine reduced in hepatomas, IRH, PBSF, PBSFSDF-1a, Pre-B cell growth-stimulating factor, SCYB12, SDF1, SDF-1, SDF1A, SDF1B, SDF1SDF-1b, stromal cell-derived factor 1, TLSF, TLSF-a, TLSF-b, TPAR1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.