product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse CXCL12/SDF-1 Antibody
catalog :
MAB350-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
489 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
79018
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 148
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:50; fig 5j
Verginadis I, Avgousti H, Monslow J, Skoufos G, Chinga F, Kim K, et al. A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression. Nat Cell Biol. 2022;24:940-953 pubmed publisher
  • immunohistochemistry; mouse; loading ...
Lee Y, Kim T, Kim Y, Kim S, Lee S, Seo S, et al. Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells. Exp Mol Med. 2021;53:1319-1331 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:150; loading ...; fig 5h
B xe9 nard A, Jacobsen A, Brunner M, Krautz C, Kl xf6 sch B, Swierzy I, et al. Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections. Nat Commun. 2021;12:1112 pubmed publisher
Donnelly H, Ross E, Xiao Y, Hermantara R, Taqi A, Doherty Boyd W, et al. Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells. Nat Commun. 2024;15:5791 pubmed publisher
Li A, Yi J, Li X, Dong L, Ostrow L, Ma J, et al. Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice. elife. 2024;12: pubmed publisher
Frenz Wiessner S, Fairley S, Buser M, Goek I, Salewskij K, Jönsson G, et al. Generation of complex bone marrow organoids from human induced pluripotent stem cells. Nat Methods. 2024;21:868-881 pubmed publisher
Zheng M, Kim M, Park S, Kim W, Oh S, Sung J. CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata. Int J Mol Sci. 2024;25: pubmed publisher
Pu T, Wang J, Wei J, Zeng A, Zhang J, Chen J, et al. Stromal-derived MAOB promotes prostate cancer growth and progression. Sci Adv. 2024;10:eadi4935 pubmed publisher
Nguyen J, Mohan E, Pandya G, Ali U, Tan C, Kofler J, et al. CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery. J Neuroinflammation. 2023;20:232 pubmed publisher
Williamson M, Le S, Franzen R, Donlan N, Rosow J, Nicot Cartsonis M, et al. Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke. Nat Commun. 2023;14:6341 pubmed publisher
Chen S, Xing Z, Geng M, Zhao R, Yang X, Zhu X, et al. Macrophage fusion event as one prerequisite for inorganic nanoparticle-induced antitumor response. Sci Adv. 2023;9:eadd9871 pubmed publisher
Kudo A, Sawahata H, Yoshimoto S, Yamauchi A, Oshita R, Kanai E, et al. Evaluation of the influence of the C-X-C motif chemokine ligand 12 / C-X-C chemokine receptor 4 axis on canine mammary gland tumor cell migration. J Vet Med Sci. 2023;85:837-843 pubmed publisher
Suvas P, Setia M, Rana M, Chakraborty A, Suvas S. Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas. Ocul Surf. 2023;28:99-107 pubmed publisher
Doolittle M, Saul D, Kaur J, Rowsey J, Vos S, Pavelko K, et al. Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton. bioRxiv. 2023;: pubmed publisher
Lunardi F, Abbrescia D, Vedovelli L, Pezzuto F, Fortarezza F, Comacchio G, et al. Molecular Profiling of Tissue Samples with Chronic Rejection from Patients with Chronic Lung Allograft Dysfunction: A Pilot Study in Cystic Fibrosis Patients. Biomolecules. 2023;13: pubmed publisher
D Alterio C, Giardino A, Scognamiglio G, Butturini G, Portella L, Guardascione G, et al. CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients. Cells. 2022;11: pubmed publisher
Wikstr xf6 m P, Bergstr xf6 m S, Josefsson A, Semenas J, Nordstrand A, Thysell E, et al. Epithelial and Stromal Characteristics of Primary Tumors Predict the Bone Metastatic Subtype of Prostate Cancer and Patient Survival after Androgen-Deprivation Therapy. Cancers (Basel). 2022;14: pubmed publisher
Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, et al. Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease. Immunity. 2022;55:2285-2299.e7 pubmed publisher
Roy I, Anu P, Zaunz S, Reddi S, Giri A, Sankar R, et al. Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function. iScience. 2022;25:105171 pubmed publisher
Dai Y, Ma J, Jiang R, Zhan X, Chen S, Feng L, et al. Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization. Cell Rep. 2022;40:111361 pubmed publisher
Holter J, Chang C, Avendano A, Garg A, Verma A, Charan M, et al. Fibroblast-derived CXCL12 increases vascular permeability in a 3-D microfluidic model independent of extracellular matrix contractility. Front Bioeng Biotechnol. 2022;10:888431 pubmed publisher
Liu C, Zhao J, Fu Y, Inoue Y, Ren Y, Chen Y, et al. Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function. Nat Neurosci. 2022;25:1020-1033 pubmed publisher
D Alterio C, Spina A, Arenare L, Chiodini P, Napolitano M, Galdiero F, et al. Biological Role of Tumor/Stromal CXCR4-CXCL12-CXCR7 in MITO16A/MaNGO-OV2 Advanced Ovarian Cancer Patients. Cancers (Basel). 2022;14: pubmed publisher
Pereira A, Trivanovi x107 D, Stahlhut P, Rudert M, Groll J, Herrmann M. Preservation of the naïve features of mesenchymal stromal cells in vitro: Comparison of cell- and bone-derived decellularized extracellular matrix. J Tissue Eng. 2022;13:20417314221074453 pubmed publisher
Fielding C, García García A, Korn C, Gadomski S, Fang Z, Reguera J, et al. Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis. Nat Commun. 2022;13:543 pubmed publisher
Jiang Z, Li H, Schroer S, Voisin V, Ju Y, Pacal M, et al. Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes. EMBO J. 2022;41:e106825 pubmed publisher
Cantini G, Fei L, Canu L, Lazzeri E, Sottili M, Francalanci M, et al. Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression. J Pers Med. 2021;11: pubmed publisher
Suárez López L, Kong Y, Sriram G, Patterson J, Rosenberg S, Morandell S, et al. MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer. Front Immunol. 2020;11:607891 pubmed publisher
Benet Z, Jing Z, Fooksman D. Plasma cell dynamics in the bone marrow niche. Cell Rep. 2021;34:108733 pubmed publisher
Kim J, Lee S, Park K. CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands. Int J Mol Sci. 2021;22: pubmed publisher
Yashiro M, Kinoshita H, Tsujio G, Fukuoka T, Yamamoto Y, Sera T, et al. SDF1α/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment. Oncol Lett. 2021;21:38 pubmed publisher
Biasci D, Smoragiewicz M, Connell C, Wang Z, Gao Y, Thaventhiran J, et al. CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response. Proc Natl Acad Sci U S A. 2020;117:28960-28970 pubmed publisher
D Alterio C, Zannetti A, Trotta A, Ierano C, Napolitano M, Rea G, et al. New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer. Cancers (Basel). 2020;12: pubmed publisher
Dong R, Bai Y, Dai J, Deng M, Zhao C, Tian Z, et al. Engineered scaffolds based on mesenchymal stem cells/preosteoclasts extracellular matrix promote bone regeneration. J Tissue Eng. 2020;11:2041731420926918 pubmed publisher
Tsai C, Yu S, Lee C, Pang J, Wu C, Lin S, et al. SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo. Oncogene. 2020;39:4695-4710 pubmed publisher
Chen Y, Li S, Lu H, Lo C. Prognostic Value of SDF-1α Expression in Patients with Esophageal Squamous Cell Carcinoma Receiving Esophagectomy. Cancers (Basel). 2020;12: pubmed publisher
Zheng J, Qu D, Wang C, Ding L, Zhou W. Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling. BMC Pregnancy Childbirth. 2020;20:87 pubmed publisher
Li L, Shirkey M, Zhang T, Xiong Y, Piao W, Saxena V, et al. The lymph node stromal laminin α5 shapes alloimmunity. J Clin Invest. 2020;130:2602-2619 pubmed publisher
Baci D, Bruno A, Cascini C, Gallazzi M, Mortara L, Sessa F, et al. Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies. J Exp Clin Cancer Res. 2019;38:464 pubmed publisher
Liu X, Tonello R, Ling Y, Gao Y, Berta T. Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1. J Neuroinflammation. 2019;16:209 pubmed publisher
Kalpana G, Figy C, Yeung M, Yeung K. Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling. Sci Rep. 2019;9:16351 pubmed publisher
Yamada M, Hokazono C, Tokizawa K, Marui S, Iwata M, Lira V, et al. Muscle-derived SDF-1α/CXCL12 modulates endothelial cell proliferation but not exercise training-induced angiogenesis. Am J Physiol Regul Integr Comp Physiol. 2019;317:R770-R779 pubmed publisher
Pansy K, Feichtinger J, Ehall B, Uhl B, Sedej M, Roula D, et al. The CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In Vitro. Int J Mol Sci. 2019;20: pubmed publisher
Miyata T, Yamashita Y, Yoshizumi T, Shiraishi M, Ohta M, Eguchi S, et al. CXCL12 expression in intrahepatic cholangiocarcinoma is associated with metastasis and poor prognosis. Cancer Sci. 2019;110:3197-3203 pubmed publisher
Sayo K, Aoki S, Kojima N. Fabrication of bone marrow-like tissue in vitro from dispersed-state bone marrow cells. Regen Ther. 2016;3:32-37 pubmed publisher
Lee G, Jeong S, Lee H, Oh I. Age-related differences in the bone marrow stem cell niche generate specialized microenvironments for the distinct regulation of normal hematopoietic and leukemia stem cells. Sci Rep. 2019;9:1007 pubmed publisher
Wang M, Yang X, Wei M, Wang Z. The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer. J Cancer. 2018;9:3898-3903 pubmed publisher
Cecchinato V, D Agostino G, Raeli L, Nerviani A, Schiraldi M, Danelon G, et al. Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis. Front Immunol. 2018;9:2118 pubmed publisher
Yoon J, Kim Y, Kwon S, Kim M, Kim Y, Kim J, et al. Senescent fibroblasts drive ageing pigmentation: ​A potential therapeutic target for senile lentigo. Theranostics. 2018;8:4620-4632 pubmed publisher
Shim B, Jin M, Moon J, Park I, Ryu H. High Cytoplasmic CXCR4 Expression Predicts Prolonged Survival in Triple-Negative Breast Cancer Patients Treated with Adjuvant Chemotherapy. J Pathol Transl Med. 2018;52:369-377 pubmed publisher
Marques C, Santos A, Gameiro A, Correia J, Ferreira F. CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors. BMC Cancer. 2018;18:741 pubmed publisher
Raschioni C, Bottai G, Sagona A, Errico V, Testori A, Gatzemeier W, et al. CXCR4/CXCL12 Signaling and Protumor Macrophages in Primary Tumors and Sentinel Lymph Nodes Are Involved in Luminal B Breast Cancer Progression. Dis Markers. 2018;2018:5018671 pubmed publisher
Chau M, Deveau T, Gu X, Kim Y, Xu Y, Yu S, et al. Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice. BMC Neurosci. 2018;19:20 pubmed publisher
Kitawaki Y, Nakamura Y, Kubota Nakayama F, Yamazaki Y, Miki Y, Hata S, et al. Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. Hum Pathol. 2018;77:88-97 pubmed publisher
De Colle C, Mönnich D, Welz S, Boeke S, Sipos B, Fend F, et al. SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy. Clin Transl Radiat Oncol. 2017;5:28-36 pubmed publisher
Maltese M, Stanic J, Tassone A, Sciamanna G, Ponterio G, Vanni V, et al. Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatum. elife. 2018;7: pubmed publisher
Tang W, Chen Y, Wang X, Chen Y, Zhang J, Lin Z. Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema. Oncol Lett. 2018;15:2501-2507 pubmed publisher
Zhang J, Liu C, Mo X, Shi H, Li S. Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer. Oncol Lett. 2018;15:1771-1776 pubmed publisher
Venkatesh A, Nandigam H, Muccioli M, Singh M, Loftus T, Lewis D, et al. Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells. Immunobiology. 2018;223:466-476 pubmed publisher
Fujita M, Davari P, Takada Y, Takada Y. Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4. Biochem J. 2018;475:723-732 pubmed publisher
Pollok K, Mothes R, Ulbricht C, Liebheit A, Gerken J, Uhlmann S, et al. The chronically inflamed central nervous system provides niches for long-lived plasma cells. Acta Neuropathol Commun. 2017;5:88 pubmed publisher
Sánchez N, Quinn K, Ashley A, Ashley R. In the ovine pituitary, CXCR4 is localized in gonadotropes and somatotropes and increases with elevated serum progesterone. Domest Anim Endocrinol. 2018;62:88-97 pubmed publisher
Katsura M, Shoji F, Okamoto T, Shimamatsu S, Hirai F, Toyokawa G, et al. Correlation between CXCR4/CXCR7/CXCL12 chemokine axis expression and prognosis in lymph-node-positive lung cancer patients. Cancer Sci. 2018;109:154-165 pubmed publisher
Omland S, Wettergren E, Mollerup S, Asplund M, Mourier T, Hansen A, et al. Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin. BMC Cancer. 2017;17:675 pubmed publisher
Zboralski D, Hoehlig K, Eulberg D, Frömming A, Vater A. Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade. Cancer Immunol Res. 2017;5:950-956 pubmed publisher
Seemann S, Zohles F, Lupp A. Comprehensive comparison of three different animal models for systemic inflammation. J Biomed Sci. 2017;24:60 pubmed publisher
McClendon J, Jansing N, Redente E, Gandjeva A, Ito Y, Colgan S, et al. Hypoxia-Inducible Factor 1? Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury. Am J Pathol. 2017;187:1772-1786 pubmed publisher
Lovshin J, Rajasekeran H, Lytvyn Y, Lovblom L, Khan S, Alemu R, et al. Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α1-67 in Patients With Type 2 Diabetes. Diabetes Care. 2017;40:1073-1081 pubmed publisher
Samarendra H, Jones K, Petrinic T, Silva M, Reddy S, Soonawalla Z, et al. A meta-analysis of CXCL12 expression for cancer prognosis. Br J Cancer. 2017;117:124-135 pubmed publisher
Kim Y, Choi Y, Lee J, Soh E, Kim J, Park T. Senescent tumor cells lead the collective invasion in thyroid cancer. Nat Commun. 2017;8:15208 pubmed publisher
Bromage D, Taferner S, Pillai M, Yellon D, Davidson S. A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies. PLoS ONE. 2017;12:e0174447 pubmed publisher
Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, et al. Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. EMBO J. 2017;36:840-853 pubmed publisher
Pierce H, Zhang D, Magnon C, Lucas D, Christin J, Huggins M, et al. Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay. Cell Stem Cell. 2017;20:648-658.e4 pubmed publisher
Uchi Y, Takeuchi H, Matsuda S, Saikawa Y, Kawakubo H, Wada N, et al. CXCL12 expression promotes esophageal squamous cell carcinoma proliferation and worsens the prognosis. BMC Cancer. 2016;16:514 pubmed publisher
Inoue Y, Saigusa S, Hiro J, Toiyama Y, Araki T, Tanaka K, et al. Clinical significance of enlarged lateral pelvic lymph nodes before and after preoperative chemoradiotherapy for rectal cancer. Mol Clin Oncol. 2016;4:994-1002 pubmed
Zhu X, Bai Q, Lu Y, Lu Y, Zhu L, Zhou X, et al. Expression and function of CXCL12/CXCR4/CXCR7 in thyroid cancer. Int J Oncol. 2016;48:2321-9 pubmed publisher
Kruizinga R, van Marion D, den Dunnen W, de Groot J, Hoving E, Oosting S, et al. Difference in CXCR4 expression between sporadic and VHL-related hemangioblastoma. Fam Cancer. 2016;15:607-16 pubmed publisher
Seemann S, Lupp A. Administration of a CXCL12 Analog in Endotoxemia Is Associated with Anti-Inflammatory, Anti-Oxidative and Cytoprotective Effects In Vivo. PLoS ONE. 2015;10:e0138389 pubmed publisher
Gibson D, Greaves E, Critchley H, Saunders P. Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2. Hum Reprod. 2015;30:1290-301 pubmed publisher
Shen C, Lie P, Miao T, Yu M, Lu Q, Feng T, et al. Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis. Mol Med Rep. 2015;12:20-30 pubmed publisher
Siddiqi F, Chen L, Advani S, Thai K, Batchu S, Alghamdi T, et al. CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney. Endocrinology. 2015;156:1121-32 pubmed publisher
Neve Polimeno M, Ierano C, D Alterio C, Simona Losito N, Napolitano M, Portella L, et al. CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not. Cell Mol Immunol. 2015;12:474-82 pubmed publisher
Wang X, Zhang H, He H, Shen Z, Tang Z, Xu J, et al. Prognostic value of stromal cell-derived factor 1 expression in patients with gastric cancer after surgical resection. Cancer Sci. 2014;105:1447-56 pubmed publisher
Sangaletti S, Tripodo C, Portararo P, Dugo M, Vitali C, Botti L, et al. Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies. Oncoimmunology. 2014;3:e28989 pubmed
Noort A, van Zoest K, Weijers E, Koolwijk P, Maracle C, Novack D, et al. NF-?B-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis. J Pathol. 2014;234:375-85 pubmed publisher
Batsi O, Giannopoulou I, Nesseris I, Valavanis C, Gakiopoulou H, Patsouris E, et al. Immunohistochemical evaluation of CXCL12-CXCR4 axis and VEGFR3 expression in primary urothelial cancer and its recurrence. Anticancer Res. 2014;34:3537-42 pubmed
Wheat R, Roberts C, Waterboer T, Steele J, Marsden J, Steven N, et al. Inflammatory cell distribution in primary merkel cell carcinoma. Cancers (Basel). 2014;6:1047-64 pubmed publisher
Hu W, Liu Y, Zhou W, Si L, Ren L. CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro. PLoS ONE. 2014;9:e99056 pubmed publisher
Geherin S, Wilson R, Jennrich S, Debes G. CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph. PLoS ONE. 2014;9:e95626 pubmed publisher
Zhang W, He L, Shi X, Wu S, Zhang B, Mei L, et al. Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease. Respir Res. 2014;15:33 pubmed publisher
Chen L, Advani S, Thai K, Kabir M, Sood M, Gibson I, et al. SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease. PLoS ONE. 2014;9:e92227 pubmed publisher
Roy I, Zimmerman N, Mackinnon A, Tsai S, Evans D, Dwinell M. CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. PLoS ONE. 2014;9:e90400 pubmed publisher
Pinto S, Martinez Romero A, O Connor J, Gil Benso R, San Miguel T, Terrádez L, et al. Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation. BMC Cancer. 2014;14:118 pubmed publisher
O Shaughnessy P, Monteiro A, Fowler P, Morris I. Identification of Leydig cell-specific mRNA transcripts in the adult rat testis. Reproduction. 2014;147:671-82 pubmed publisher
Walters M, Ebsworth K, Berahovich R, Penfold M, Liu S, Al Omran R, et al. Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats. Br J Cancer. 2014;110:1179-88 pubmed publisher
D Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, et al. A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients. Int J Cancer. 2014;135:379-90 pubmed publisher
Klink B, Miletic H, Stieber D, Huszthy P, Campos Valenzuela J, Valenzuela J, et al. A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1. PLoS ONE. 2013;8:e59773 pubmed publisher
Akhtar S, Gremse F, Kiessling F, Weber C, Schober A. CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice. Arterioscler Thromb Vasc Biol. 2013;33:679-86 pubmed publisher
Warner J, Zwezdaryk K, Day B, Sullivan D, Pridjian G, Morris C. Human cytomegalovirus infection inhibits CXCL12- mediated migration and invasion of human extravillous cytotrophoblasts. Virol J. 2012;9:255 pubmed publisher
Wang L, Chen W, Gao L, Yang Q, Liu B, Wu Z, et al. High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma. World J Surg Oncol. 2012;10:212 pubmed publisher
Lee H, Huang S, Kim H, Oh Y, Hwang J, Liang Z, et al. Evaluation of the combined expression of chemokine SDF-1? and its receptor CXCR4 as a prognostic marker for gastric cancer. Exp Ther Med. 2011;2:499-504 pubmed
Liberman J, Sartelet H, Flahaut M, Mühlethaler Mottet A, Coulon A, Nyalendo C, et al. Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma. PLoS ONE. 2012;7:e43665 pubmed publisher
Song I, Liang Z, Lee J, Huang S, Kim H, Oh Y, et al. Expression of stromal cell-derived factor-1? is an independent risk factor for lymph node metastasis in early gastric cancer. Oncol Lett. 2011;2:1197-1202 pubmed
Kayali A, Lopez A, Hao E, Hinton A, Hayek A, King C. The SDF-1?/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells. PLoS ONE. 2012;7:e38721 pubmed publisher
Najbauer J, Huszthy P, Barish M, Garcia E, Metz M, Myers S, et al. Cellular host responses to gliomas. PLoS ONE. 2012;7:e35150 pubmed publisher
Popple A, Durrant L, Spendlove I, Rolland P, Scott I, Deen S, et al. The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer. Br J Cancer. 2012;106:1306-13 pubmed publisher
D Alterio C, Barbieri A, Portella L, Palma G, Polimeno M, Riccio A, et al. Inhibition of stromal CXCR4 impairs development of lung metastases. Cancer Immunol Immunother. 2012;61:1713-20 pubmed
Harris R, Chianese Bullock K, Petroni G, Schaefer J, Brill L, Molhoek K, et al. The vaccine-site microenvironment induced by injection of incomplete Freund's adjuvant, with or without melanoma peptides. J Immunother. 2012;35:78-88 pubmed publisher
Kulbe H, Chakravarty P, Leinster D, Charles K, Kwong J, Thompson R, et al. A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. Cancer Res. 2012;72:66-75 pubmed publisher
Dorfmuller P, Chaumais M, Giannakouli M, Durand Gasselin I, Raymond N, Fadel E, et al. Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension. Respir Res. 2011;12:119 pubmed publisher
Guo L, Cui Z, Zhang J, Huang Y. Chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 correlate with lymph node metastasis in epithelial ovarian carcinoma. Chin J Cancer. 2011;30:336-43 pubmed
Yan M, Jene N, Byrne D, Millar E, O Toole S, McNeil C, et al. Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers. Breast Cancer Res. 2011;13:R47 pubmed publisher
Chow A, Lucas D, Hidalgo A, Mendez Ferrer S, Hashimoto D, Scheiermann C, et al. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med. 2011;208:261-71 pubmed publisher
Kerr W. Inhibitor and activator: dual functions for SHIP in immunity and cancer. Ann N Y Acad Sci. 2011;1217:1-17 pubmed publisher
Toullec A, Gerald D, Despouy G, Bourachot B, Cardon M, Lefort S, et al. Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol Med. 2010;2:211-30 pubmed publisher
Roy H, Bhardwaj S, Babu M, Lähteenvuo J, Yla Herttuala S. VEGF-DdeltaNdeltaC mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits. Eur J Clin Invest. 2010;40:422-32 pubmed publisher
Lee W, Suzuki Y, Graves S, Iwata M, Venkataraman G, Mielcarek M, et al. Canine bone marrow-derived mesenchymal stromal cells suppress alloreactive lymphocyte proliferation in vitro but fail to enhance engraftment in canine bone marrow transplantation. Biol Blood Marrow Transplant. 2011;17:465-75 pubmed publisher
Eberlein J, Nguyen T, Victorino F, Golden Mason L, Rosen H, Homann D. Comprehensive assessment of chemokine expression profiles by flow cytometry. J Clin Invest. 2010;120:907-23 pubmed publisher
Margaritopoulos G, Antoniou K, Soufla G, Karagiannis K, Proklou A, Lasithiotaki I, et al. Upregulation of stromal cell derived factor-1alpha in collagen vascular diseases-associated interstitial pneumonias (CVDs-IPs). Pulm Pharmacol Ther. 2010;23:115-20 pubmed publisher
Sayyed S, Hägele H, Kulkarni O, Endlich K, Segerer S, Eulberg D, et al. Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes. Diabetologia. 2009;52:2445-54 pubmed publisher
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product information
brand :
R&D Systems
master code :
MAB350
SKU :
MAB350-100
product name :
Human/Mouse CXCL12/SDF-1 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The Human/Mouse CXCL12/SDF-1 Antibody from R&D Systems is a mouse monoclonal antibody to CXCL12/SDF-1. This antibody reacts with feline,human,mouse,rabbit,rat,transgenic mouse,xenograft. The Human/Mouse CXCL12/SDF-1 Antibody has been validated for the following applications: Immunohistochemistry,Immunocytochemistry,ELISA Development,ELISA Development (Capture),ELISA Development (Detection),Luminex Development,Flow Cytometry,Western Blot,Mass Spectrometry,Neutralization,Functional Assay,ELISA Capture,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,ELISA Capture (Matched Antibody Pair),Intracellular Staining by Flow Cytometry,CyTOF-ready,Dual RNAscope ISH-IHC Compatible.
target :
CXCL12/SDF-1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
79018
conjugate :
Unconjugated
dilution :
Immunohistochemistry 8-25 ug/mL, Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells, Immunocytochemistry 8-15 ug/mL, CyTOF-ready, Dual RNAscope ISH-IHC 5-25 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
host :
Mouse
immunogen :
E. coli -derived recombinant human CXCL12/SDF-1 alpha , Lys22-Lys89, Accession # Q6ICW0
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Feline,Human,Mouse,Rabbit,Rat,Transgenic Mouse,Xenograft
specificity :
Detects human and mouse CXCL12/SDF-1 alpha and CXCL12/SDF-1▀ in ELISAs.
gene symbol :
CXCL12
Antibody validation :
Orthogonal Validation
top caption :
CXCL12/SDF-1 antibody in Human PBMCs and K562 Human Cell Line by Immunocytochemistry (ICC).
accessionNumbers :
Q6ICW0
applications :
ELISA Capture (Matched Antibody Pair),Intracellular Staining by Flow Cytometry,CyTOF-ready,Dual RNAscope ISH-IHC Compatible,ELISA Development,ELISA Development (Capture),ELISA Development (Detection),Luminex Development,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,Mass Spectrometry,Neutralization,Immunocytochemistry,Functional Assay,ELISA Capture
USD :
489 USD
alt names :
chemokine (C-X-C motif) ligand 12, C-X-C motif chemokine 12, hIRH, hSDF-1, Intercrine reduced in hepatomas, IRH, PBSF, PBSFSDF-1a, Pre-B cell growth-stimulating factor, SCYB12, SDF1, SDF-1, SDF1A, SDF1B, SDF1SDF-1b, stromal cell-derived factor 1, TLSF, TLSF-a, TLSF-b, TPAR1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.