Human CD28 Antibody | R&D Systems MAB342 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CD28 Antibody

catalog :

MAB342

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

37407

reactivity :

human

application :

western blot

citations: 31

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 5f	Levy R, Rotfogel Z, Hillman D, Popugailo A, Arad G, Supper E, et al. Superantigens hyperinduce inflammatory cytokines by enhancing the B7-2/CD28 costimulatory receptor interaction. Proc Natl Acad Sci U S A. 2016;113:E6437-E6446 pubmed
	Tiirikainen M, Woetmann A, Norsgaard H, Santamaria Babi L, Lovato P. Ex vivo culture of lesional psoriasis skin for pharmacological testing. J Dermatol Sci. 2020;97:109-116 pubmed publisher
	Lu Y, Yoo B, Ng A, Kim J, Yeom S, TANG J, et al. 4D electron microscopy of T cell activation. Proc Natl Acad Sci U S A. 2019;116:22014-22019 pubmed publisher
	Chamcheu J, Esnault S, Adhami V, Noll A, Banang Mbeumi S, Roy T, et al. Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models. Cells. 2019;8: pubmed publisher
	Zhou N, Wang K, Fu Z. Effect of morphine and a low dose of ketamine on the T cells of patients with refractory cancer pain in vitro. Oncol Lett. 2019;18:4230-4236 pubmed publisher
	Bensch F, van der Veen E, Lub de Hooge M, Jorritsma Smit A, Boellaard R, Kok I, et al. 89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer. Nat Med. 2018;24:1852-1858 pubmed publisher
	Giacomet V, Masetti M, Nannini P, Forlanini F, Clerici M, Zuccotti G, et al. Humoral and cell-mediated immune responses after a booster dose of HBV vaccine in HIV-infected children, adolescents and young adults. PLoS ONE. 2018;13:e0192638 pubmed publisher
	Caer C, Rouault C, Le Roy T, Poitou C, Aron Wisnewsky J, Torcivia A, et al. Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue. Sci Rep. 2017;7:3000 pubmed publisher
	Nakachi S, Sumitomo S, Tsuchida Y, Tsuchiya H, Kono M, Kato R, et al. Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis. Arthritis Res Ther. 2017;19:97 pubmed publisher
	Tao C, Shao H, Zhang W, Bo H, Wu F, Shen H, et al. ??TCR immunoglobulin constant region domain exchange in human ??TCRs improves TCR pairing without altering TCR gene-modified T cell function. Mol Med Rep. 2017;15:1555-1564 pubmed publisher
	Van Belle T, Vanherwegen A, Feyaerts D, De Clercq P, Verstuyf A, Korf H, et al. 1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients. PLoS ONE. 2014;9:e109194 pubmed publisher
	Zhu L, Huang Z, Stålesen R, Hansson G, Li N. Platelets provoke distinct dynamics of immune responses by differentially regulating CD4+ T-cell proliferation. J Thromb Haemost. 2014;12:1156-65 pubmed publisher
	Foley M, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, et al. High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function. PLoS ONE. 2014;9:e87873 pubmed publisher
	Dalmas E, Venteclef N, Caer C, Poitou C, Cremer I, Aron Wisnewsky J, et al. T cell-derived IL-22 amplifies IL-1?-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes. Diabetes. 2014;63:1966-77 pubmed publisher
	Renand A, Milpied P, Rossignol J, Bruneau J, Lemonnier F, Dussiot M, et al. Neuropilin-1 expression characterizes T follicular helper (Tfh) cells activated during B cell differentiation in human secondary lymphoid organs. PLoS ONE. 2013;8:e85589 pubmed publisher
	Gironi M, Saresella M, Rovaris M, Vaghi M, Nemni R, Clerici M, et al. A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis. Immun Ageing. 2013;10:1 pubmed publisher
	Wolk K, Witte E, Warszawska K, Schulze Tanzil G, Witte K, Philipp S, et al. The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur J Immunol. 2009;39:3570-81 pubmed publisher
	Hirosako S, Goto E, Fujii K, Tsumori K, Hirata N, Tsumura S, et al. Human bronchial intraepithelial T cells produce interferon-gamma and stimulate epithelial cells. Clin Exp Immunol. 2009;155:266-74 pubmed publisher
	Lazer G, Pe er L, Schapira V, Richard S, Katzav S. The association of Sam68 with Vav1 contributes to tumorigenesis. Cell Signal. 2007;19:2479-86 pubmed
	Celis E. Overlapping human leukocyte antigen class I/II binding peptide vaccine for the treatment of patients with stage IV melanoma: evidence of systemic immune dysfunction. Cancer. 2007;110:203-14 pubmed
	Sakthivel P, Shively V, Kakoulidou M, Pearce W, Lefvert A. The soluble forms of CD28, CD86 and CTLA-4 constitute possible immunological markers in patients with abdominal aortic aneurysm. J Intern Med. 2007;261:399-407 pubmed
	Bayry J, Triebel F, Kaveri S, Tough D. Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. J Immunol. 2007;178:4184-93 pubmed
	Srinivasan M, Eri R, Zunt S, Summerlin D, Brand D, Blum J. Suppression of immune responses in collagen-induced arthritis by a rationally designed CD80-binding peptide agent. Arthritis Rheum. 2007;56:498-508 pubmed
	Piconi S, Trabattoni D, Saresella M, Iemoli E, Schenal M, Fusi A, et al. Effects of specific immunotherapy on the B7 family of costimulatory molecules in allergic inflammation. J Immunol. 2007;178:1931-7 pubmed
	Mamoni R, Blotta M. Flow-cytometric analysis of cytokine production in human paracoccidioidomycosis. Cytokine. 2006;35:207-16 pubmed
	Neuber K, Mähnss B, Hubner C, Gergely H, Weichenthal M. Autoantibodies against CD28 are associated with atopic diseases. Clin Exp Immunol. 2006;146:262-9 pubmed
	Ogilvie R, Abelson M, Hau H, Vlasova I, Blackshear P, Bohjanen P. Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay. J Immunol. 2005;174:953-61 pubmed
	Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R. IL-22 increases the innate immunity of tissues. Immunity. 2004;21:241-54 pubmed
	Wang P, Zhang J, Bian H, Wu P, Kuvelkar R, Kung T, et al. Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor. Biochem J. 2004;380:425-33 pubmed
	Janardhan A, Swigut T, Hill B, Myers M, Skowronski J. HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis. PLoS Biol. 2004;2:E6 pubmed
	Wolk K, Kunz S, Asadullah K, Sabat R. Cutting edge: immune cells as sources and targets of the IL-10 family members?. J Immunol. 2002;168:5397-402 pubmed

product information

brand :

R&D Systems

master code :

MAB342

SKU :

MAB342-100

product name :

Human CD28 Antibody

description :

The Human CD28 Antibody from R&D Systems is a mouse monoclonal antibody to CD28. This antibody reacts with human. The Human CD28 Antibody has been validated for the following applications: Western Blot, Agonist Activity.

target :

CD28

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

37407

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human CD28, Asn19-Pro152, Accession # P10747

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human CD28 in Western blots. In Western blots, this antibody does not cross-react with recombinant mouse (rm) CD28, rhCTLA4, or rmCTLA4.

gene symbol :

CD28

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB342

accessionNumbers :

P10747

applications :

Western Blot, Agonist Activity

2020 USD :

339

2021 USD :

369 USD

alt names :

CD28, CD28 antigen, CD28 antigen (Tp44), CD28 molecule, MGC138290, T-cell-specific surface glycoprotein CD28, Tp44

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.