Human CD28 Antibody | R&D Systems MAB342-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CD28 Antibody

catalog :

MAB342-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

37407

reactivity :

human, mouse

application :

western blot, immunocytochemistry, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 48

Reference
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Mez x151 si Csapl xe1 r M, Sz xf6 x151 r x, Vereb G. CD28 and 41BB Costimulatory Domains Alone or in Combination Differentially Influence Cell Surface Dynamics and Organization of Chimeric Antigen Receptors and Early Activation of CAR T Cells. Cancers (Basel). 2023;15: pubmed publisher
Liu S, Zhang Q, Zhang M, Zhong X, Wang W, Wang L, et al. Reduced circulating interleukin 35 is associated with enhanced peripheral T cell function in primary biliary cholangitis. Biomol Biomed. 2023;23:248-258 pubmed publisher
Bretheau F, Castellanos Molina A, B xe9 langer D, Kusik M, Mailhot B, Boisvert A, et al. The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury. Nat Commun. 2022;13:5786 pubmed publisher
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Yang L, Liu S, Zhang Q, Jia S, Qiu C, Jin Z. Overexpression of ascitic interleukin-35 induces CD8+ T cell exhaustion in liver cirrhotic patients with spontaneous bacterial peritonitis. Int Immunopharmacol. 2022;108:108729 pubmed publisher
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Huetter J, Gritzan U, Gutcher I, Doecke W, Luetke Eversloh M, Golfier S, et al. Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2). Cancer Immunol Res. 2020;8:895-911 pubmed publisher
Hu Z, Yu P, Du G, Wang W, Zhu H, Li N, et al. PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice. PLoS ONE. 2020;15:e0228339 pubmed publisher
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Lu Y, Yoo B, Ng A, Kim J, Yeom S, TANG J, et al. 4D electron microscopy of T cell activation. Proc Natl Acad Sci U S A. 2019;116:22014-22019 pubmed publisher
Chamcheu J, Esnault S, Adhami V, Noll A, Banang Mbeumi S, Roy T, et al. Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models. Cells. 2019;8: pubmed publisher
Zhou N, Wang K, Fu Z. Effect of morphine and a low dose of ketamine on the T cells of patients with refractory cancer pain in vitro. Oncol Lett. 2019;18:4230-4236 pubmed publisher
Garrett S, Zhao Q, Feghali Bostwick C. Induction of a Th17 Phenotype in Human Skin-A Mimic of Dermal Inflammatory Diseases. Methods Protoc. 2019;2: pubmed publisher
Bensch F, van der Veen E, Lub de Hooge M, Jorritsma Smit A, Boellaard R, Kok I, et al. 89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer. Nat Med. 2018;24:1852-1858 pubmed publisher
Giacomet V, Masetti M, Nannini P, Forlanini F, Clerici M, Zuccotti G, et al. Humoral and cell-mediated immune responses after a booster dose of HBV vaccine in HIV-infected children, adolescents and young adults. PLoS ONE. 2018;13:e0192638 pubmed publisher
Caer C, Rouault C, Le Roy T, Poitou C, Aron Wisnewsky J, Torcivia A, et al. Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue. Sci Rep. 2017;7:3000 pubmed publisher
Nakachi S, Sumitomo S, Tsuchida Y, Tsuchiya H, Kono M, Kato R, et al. Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis. Arthritis Res Ther. 2017;19:97 pubmed publisher
Tao C, Shao H, Zhang W, Bo H, Wu F, Shen H, et al. ??TCR immunoglobulin constant region domain exchange in human ??TCRs improves TCR pairing without altering TCR gene-modified T cell function. Mol Med Rep. 2017;15:1555-1564 pubmed publisher
Shi J, Zhang D, Cui Z, Wang H. Preparation and application of a novel monoclonal antibody specific for human B7-H3. Mol Med Rep. 2016;14:943-8 pubmed publisher
Bredo G, Storie J, Shrestha Palikhe N, Davidson C, Adams A, Vliagoftis H, et al. Interleukin-25 initiates Th2 differentiation of human CD4(+) T cells and influences expression of its own receptor. Immun Inflamm Dis. 2015;3:455-68 pubmed publisher
Herrera R, Morris M, Rosbe K, Feng Z, Weinberg A, Tugizov S. Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells. Virology. 2016;487:172-87 pubmed publisher
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Moore C, Cui Q, Warsi N, Durafourt B, Zorko N, Owen D, et al. Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation. J Immunol. 2015;194:761-72 pubmed publisher
Van Belle T, Vanherwegen A, Feyaerts D, De Clercq P, Verstuyf A, Korf H, et al. 1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients. PLoS ONE. 2014;9:e109194 pubmed publisher
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product information

brand :

R&D Systems

master code :

MAB342

SKU :

MAB342-100

product name :

Human CD28 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human CD28 Antibody from R&D Systems is a mouse monoclonal antibody to CD28. This antibody reacts with human,mouse. The Human CD28 Antibody has been validated for the following applications: Bioassay,Binding Assay,ELISA Development,Polarization,Stimulation,T Cell Activation,Tissue Culture,Flow Cytometry,Western Blot,Neutralization,Functional Assay,Cell Culture,Immunocytochemistry,Agonist Activity.

target :

CD28

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

37407

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Agonist Activity 0.2-0.6 ug/mL, Immunocytochemistry 8-25 ug/mL

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human CD28, Asn19-Pro152, Accession # P10747

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human,Mouse

specificity :

Detects human CD28 in Western blots. In Western blots, this antibody does not cross-react with recombinant mouse (rm) CD28, rhCTLA4, or rmCTLA4.

gene symbol :

CD28

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Human CD28 Antibody Enhances IL-2 Secretion antibody in Jurkat Cells.

accessionNumbers :

P10747

applications :

Agonist Activity,Bioassay,Binding Assay,ELISA Development,Polarization,Stimulation,T Cell Activation,Tissue Culture,Flow Cytometry,Western Blot,Neutralization,Immunocytochemistry,Functional Assay,Cell Culture

USD :

489 USD

alt names :

CD28, CD28 antigen, CD28 antigen (Tp44), CD28 molecule, MGC138290, T-cell-specific surface glycoprotein CD28, Tp44

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage