Human/Mouse cIAP Pan-specific Antibody | R&D Systems MAB3400 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse cIAP Pan-specific Antibody

catalog :

MAB3400

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

315301

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 26

Reference
Dum xe9 tier B, Zadoroznyj A, Berthelet J, Causse S, All xe8 gre J, Bourgeois P, et al. cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3. Oncogene. 2023;42:198-208 pubmed publisher
Liu X, Yao J, Chen Z, Lei W, Duan R, Yao Z. Lipopolysaccharide sensitizes the therapeutic response of breast cancer to IAP antagonist. Front Immunol. 2022;13:906357 pubmed publisher
Wu G, Li D, Liang W, Sun W, Xie X, Tong Y, et al. PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFα-mediated cell death. Cell Death Dis. 2022;13:773 pubmed publisher
Garc xed a Guti xe9 rrez L, Fallahi E, Aboud N, Quinn N, Matallanas D. Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner. Cell Death Dis. 2022;13:692 pubmed publisher
Montinaro A, Areso Zubiaur I, Saggau J, Kretz A, Ferreira R, Hassan O, et al. Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers. Cell Death Differ. 2022;29:492-503 pubmed publisher
Hu Y, Zhang H, Xie N, Liu D, Jiang Y, Liu Z, et al. Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. Cell Death Differ. 2021;: pubmed publisher
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella J, et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12:2482 pubmed publisher
Pache L, Marsden M, Teriete P, Portillo A, Heimann D, Kim J, et al. Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo. Cell Rep Med. 2020;1:100037 pubmed publisher
Kang I, Jang J, Kim C. Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation. Sci Rep. 2020;10:7024 pubmed publisher
Lei W, Duan R, Li J, Liu X, Huston A, Boyce B, et al. The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice. Sci Rep. 2020;10:7004 pubmed publisher
Barnhouse V, Weist J, Shukla V, Ghadiali S, Kniss D, Leight J. Myoferlin regulates epithelial cancer cell plasticity and migration through autocrine TGF-β1 signaling. Oncotarget. 2018;9:19209-19222 pubmed publisher
Goncharov T, Hedayati S, Mulvihill M, Izrael Tomasevic A, Zobel K, Jeet S, et al. Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling. Mol Cell. 2018;69:551-565.e7 pubmed publisher
Welsh K, Milutinovic S, Ardecky R, Gonzalez López M, Ganji S, Teriete P, et al. Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis. PLoS ONE. 2016;11:e0161952 pubmed publisher
Helmke C, Raab M, Rodel F, Matthess Y, Oellerich T, Mandal R, et al. Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8. Cell Res. 2016;26:914-34 pubmed publisher
Rebolleda N, Losada Fernandez I, Perez Chacon G, Castejon R, Rosado S, Morado M, et al. Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PLoS ONE. 2016;11:e0154159 pubmed publisher
Zhang L, Blackwell K, Workman L, Chen S, Pope M, Janz S, et al. RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-ÎºB Activation and Lymphoma Survival. Mol Cell Biol. 2015;35:3324-38 pubmed publisher
Moriwaki K, Bertin J, Gough P, Chan F. A RIPK3-caspase 8 complex mediates atypical pro-IL-1Î² processing. J Immunol. 2015;194:1938-44 pubmed publisher
Zhang L, Dittmer M, Blackwell K, Workman L, Hostager B, Habelhah H. TRAIL activates JNK and NF-ÎºB through RIP1-dependent and -independent pathways. Cell Signal. 2015;27:306-14 pubmed publisher
Faye M, Beug S, Graber T, Earl N, Xiang X, Wild B, et al. IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1. Oncogene. 2015;34:1532-41 pubmed publisher
Yang S, Wang B, Tang L, Siednienko J, Callanan J, Moynagh P. Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-?. Nat Commun. 2013;4:2583 pubmed publisher
Yang S, Wang B, Humphries F, Jackson R, Healy M, Bergin R, et al. Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis. Nat Immunol. 2013;14:927-36 pubmed publisher
Moreno Garcia M, Sommer K, Rincón Arano H, Brault M, Ninomiya Tsuji J, Matesic L, et al. Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-?B activation. Mol Cell Biol. 2013;33:1149-63 pubmed publisher
Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, et al. Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat Immunol. 2012;13:1178-86 pubmed publisher
Perez Chacon G, Llobet D, Pardo C, Pindado J, Choi Y, Reed J, et al. TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice. J Immunol. 2012;189:1053-61 pubmed publisher
Gerlach B, Cordier S, Schmukle A, Emmerich C, Rieser E, Haas T, et al. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature. 2011;471:591-6 pubmed publisher
Jin H, Jin X, Lee J. Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-?B pathway. Biochem Biophys Res Commun. 2010;400:581-6 pubmed publisher

product information

brand :

R&D Systems

master code :

MAB3400

SKU :

MAB3400

product name :

Human/Mouse cIAP Pan-specific Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human/Mouse cIAP Pan-specific Antibody from R&D Systems is a mouse monoclonal antibody to cIAP (pan). This antibody reacts with avian - chicken,human,mouse. The Human/Mouse cIAP Pan-specific Antibody has been validated for the following applications: Flow Cytometry,Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Simple Western.

target :

cIAP (pan)

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

315301

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.5 ug/mL, Simple Western 10 ug/mL

host :

Mouse

immunogen :

E. coli -derived recombinant human cIAP-2, Asn2-Ser604, Accession # Q13489

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Avian - Chicken,Human,Mouse

specificity :

Detects human and mouse cIAP-1 and cIAP-2 in Western blots.

top caption :

Detection of Human/Mouse cIAP antibody by Western Blot.

accessionNumbers :

Q13489

applications :

Simple Western,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin

USD :

469 USD

alt names :

AIP1;API2;Baculoviral IAP repeat-containing protein 3;BIRC3;CIAP2;c-IAP2;HAIP1;HIAP1;IAP-1;MALT2;MIHC;RNF49, BIRC, BIRC2, BIRC3, cIAP1, cIAP2, HIAP, HIAP-1, HIAP-2, MIHB, MIHC

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage