product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse/Rat Activin A ▀A subunit Antibody
catalog :
MAB3381-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
69403
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry
more info or order :
R&D Systems product webpage
citations: 24
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 2d
Webb L, Fra Bido S, Innocentin S, Matheson L, Attaf N, Bignon A, et al. Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ. Aging Cell. 2021;20:e13295 pubmed publisher
Hrncir H, Bombin S, Goodloe B, Hogan C, Jadi O, Gracz A. Sox9 links biliary maturation to branching morphogenesis. bioRxiv. 2024;: pubmed publisher
Culver A, Hamang M, Wang Y, Jiang H, Yanum J, White E, et al. GDF8 Contributes to Liver Fibrogenesis and Concomitant Skeletal Muscle Wasting. Biomedicines. 2023;11: pubmed publisher
Wang Y, Hamang M, Culver A, Jiang H, Yanum J, Garcia V, et al. Activin B promotes the initiation and progression of liver fibrosis. Hepatol Commun. 2022;6:2812-2826 pubmed publisher
Zhu Y, Prata L, Gerdes E, Netto J, Pirtskhalava T, Giorgadze N, et al. Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans. EBioMedicine. 2022;77:103912 pubmed publisher
Mancinelli G, Torres C, Krett N, Bauer J, Castellanos K, McKinney R, et al. Role of stromal activin A in human pancreatic cancer and metastasis in mice. Sci Rep. 2021;11:7986 pubmed publisher
Cheng Q, Jabbari K, Winkelmaier G, Andersen C, Yaswen P, Khoshdeli M, et al. Overexpression of CD36 in mammary fibroblasts suppresses colony growth in breast cancer cell lines. Biochem Biophys Res Commun. 2020;526:41-47 pubmed publisher
Pettersen K, Andersen S, van der Veen A, Nonstad U, Hatakeyama S, Lambert C, et al. Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia. J Cachexia Sarcopenia Muscle. 2020;11:195-207 pubmed publisher
Zhang Z, Wang J, Chen Y, Suo L, Chen H, Zhu L, et al. Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway. Cell Commun Signal. 2019;17:45 pubmed publisher
Nieto C, Bragado R, Municio C, Sierra Filardi E, Alonso B, Escribese M, et al. The Activin A-Peroxisome Proliferator-Activated Receptor Gamma Axis Contributes to the Transcriptome of GM-CSF-Conditioned Human Macrophages. Front Immunol. 2018;9:31 pubmed publisher
Spottiswoode N, Armitage A, Williams A, Fyfe A, Biswas S, Hodgson S, et al. Role of Activins in Hepcidin Regulation during Malaria. Infect Immun. 2017;85: pubmed publisher
Locci M, Wu J, Arumemi F, Mikulski Z, Dahlberg C, Miller A, et al. Activin A programs the differentiation of human TFH cells. Nat Immunol. 2016;17:976-84 pubmed publisher
Ding Z, Jin G, Wang W, Sun Y, Chen W, Chen L, et al. Activin A-Smad Signaling Mediates Connective Tissue Growth Factor Synthesis in Liver Progenitor Cells. Int J Mol Sci. 2016;17:408 pubmed publisher
Xu M, Palmer A, Ding H, Weivoda M, Pirtskhalava T, White T, et al. Targeting senescent cells enhances adipogenesis and metabolic function in old age. elife. 2015;4:e12997 pubmed publisher
Bufalino A, Cervigne N, de Oliveira C, Fonseca F, Rodrigues P, Macedo C, et al. Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis. PLoS ONE. 2015;10:e0136599 pubmed publisher
Merfeld Clauss S, Lupov I, Lu H, March K, Traktuev D. Adipose Stromal Cell Contact with Endothelial Cells Results in Loss of Complementary Vasculogenic Activity Mediated by Induction of Activin A. Stem Cells. 2015;33:3039-51 pubmed publisher
Sierra Filardi E, Nieto C, Dominguez Soto A, Barroso R, Sánchez Mateos P, Puig Kröger A, et al. CCL2 shapes macrophage polarization by GM-CSF and M-CSF: identification of CCL2/CCR2-dependent gene expression profile. J Immunol. 2014;192:3858-67 pubmed publisher
Di X, Andrews D, Tucker C, Yu L, Moore A, Zheng X, et al. A high concentration of genistein down-regulates activin A, Smad3 and other TGF-? pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012;44:281-92 pubmed publisher
Sierra Filardi E, Puig Kröger A, Blanco F, Nieto C, Bragado R, Palomero M, et al. Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood. 2011;117:5092-101 pubmed publisher
Alexander S, Watt F, Sawaji Y, Hermansson M, Saklatvala J. Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB. Arthritis Rheum. 2007;56:3715-25 pubmed
Kupershmidt L, Amit T, Bar Am O, Youdim M, Blumenfeld Z. The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases. J Neurochem. 2007;103:962-71 pubmed
Greber B, Lehrach H, Adjaye J. Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells. 2007;25:455-64 pubmed
Funaba M, Nakaya K, Ikeda T, Murakami M, Tsuchida K, Sugino H. Requirement of Smad3 for mast cell growth. Cell Immunol. 2006;240:47-52 pubmed
Yoshinaga K, Inoue H, Utsunomiya T, Sonoda H, Masuda T, Mimori K, et al. N-cadherin is regulated by activin A and associated with tumor aggressiveness in esophageal carcinoma. Clin Cancer Res. 2004;10:5702-7 pubmed
product information
brand :
R&D Systems
master code :
MAB3381
SKU :
MAB3381-100
product name :
Human/Mouse/Rat Activin A ▀A subunit Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The Human/Mouse/Rat Activin A ßA subunit Antibody from R&D Systems is a mouse monoclonal antibody to Activin A. This antibody reacts with human,mouse,porcine,rat. The Human/Mouse/Rat Activin A ßA subunit Antibody has been validated for the following applications: Bioassay,Blocking,ELISA Development,Western Blot,Neutralization,Immunohistochemistry,In vivo assay,Immunocytochemistry,ELISA Capture (Matched Antibody Pair).
target :
Activin A
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
69403
conjugate :
Unconjugated
dilution :
Neutralization 0.02-0.06 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
host :
Mouse
immunogen :
Chinese hamster ovary cell line CHO-derived recombinant human Activin A
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Porcine,Rat
specificity :
Detects recombinant human Activin A in ELISAs. Also recognizes Activin A precursor. The amino acid sequences of mature ▀A subunits from human, mouse and rat are identical. Therefore, this antibody will also detect the mature ▀A subunit from mouse and rat.
gene symbol :
INHBA
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Hemoglobin Expression Induced by Activin A and Neutralization by Human/ Mouse/Rat Activin A Antibody.
applications :
ELISA Capture (Matched Antibody Pair),Bioassay,Blocking,ELISA Development,Immunohistochemistry,Western Blot,In vivo assay,Neutralization,Immunocytochemistry
USD :
479 USD
alt names :
activin AB alpha polypeptide, Activin beta-A chain, erythroid differentiation factor, Erythroid differentiation protein, follicle-stimulating hormone-releasing protein, FSH-releasing protein, inhibin beta A chain, inhibin beta A subunit, Inhibin, beta-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.