Human CXCR1/IL-8RA Antibody | R&D Systems MAB330-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CXCR1/IL-8RA Antibody

catalog :

MAB330-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

42705

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 50

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:800; fig 4g	Sarvestani S, SIGNS S, Hu B, Yeu Y, Feng H, Ni Y, et al. Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity. Nat Commun. 2021;12:262 pubmed publisher
	Zhao C, Wang D, Li Z, Zhang Z, Xu Y, Liu J, et al. IL8 derived from macrophages inhibits CD8+ T-cell function by downregulating TIM3 expression through IL8-CXCR2 axis in patients with advanced colorectal cancer. Int Immunopharmacol. 2023;121:110457 pubmed publisher
	Tsukamoto S, Koma Y, Kitamura Y, Tanigawa K, Azumi Y, Miyako S, et al. Matrix Metalloproteinase 9 Induced in Esophageal Squamous Cell Carcinoma Cells via Close Contact with Tumor-Associated Macrophages Contributes to Cancer Progression and Poor Prognosis. Cancers (Basel). 2023;15: pubmed publisher
	Gu xe9 rard A, Laurent V, Fromont G, Est xe8 ve D, Gilhodes J, Bonnelye E, et al. The Chemokine Receptor CCR3 Is Potentially Involved in the Homing of Prostate Cancer Cells to Bone: Implication of Bone-Marrow Adipocytes. Int J Mol Sci. 2021;22: pubmed publisher
	Hart P, Kenny H, Grassl N, Watters K, Litchfield L, Coscia F, et al. Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk. Cell Rep. 2019;29:4086-4098.e6 pubmed publisher
	Hoogendijk A, Pourfarzad F, Aarts C, Tool A, Hiemstra I, Grassi L, et al. Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming. Cell Rep. 2019;29:2505-2519.e4 pubmed publisher
	Caccuri F, Bugatti A, Corbellini S, Roversi S, Zani A, Mazzuca P, et al. The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3). Int J Mol Sci. 2019;20: pubmed publisher
	Klein O, Krier Burris R, Lazki Hagenbach P, Gorzalczany Y, Mei Y, Ji P, et al. Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity. J Allergy Clin Immunol. 2019;144:1074-1090 pubmed publisher
	Syu G, Wang S, Ma G, Liu S, Pearce D, Prakash A, et al. Development and application of a high-content virion display human GPCR array. Nat Commun. 2019;10:1997 pubmed publisher
	Sharma I, Singh A, Siraj F, Saxena S. IL-8/CXCR1/2 signalling promotes tumor cell proliferation, invasion and vascular mimicry in glioblastoma. J Biomed Sci. 2018;25:62 pubmed publisher
	Kwon E, Todorova K, Wang J, Horos R, Lee K, Neel V, et al. The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level. Nat Commun. 2018;9:1734 pubmed publisher
	Hung C, Chen F, Lin Y, Tsai M, Wang S, Chen Y, et al. Altered monocyte differentiation and macrophage polarization patterns in patients with breast cancer. BMC Cancer. 2018;18:366 pubmed publisher
	Mazzuca P, Marsico S, Schulze K, Mitola S, Pils M, Giagulli C, et al. Role of Autophagy in HIV-1 Matrix Protein p17-Driven Lymphangiogenesis. J Virol. 2017;91: pubmed publisher
	Loi A, Hoonhorst S, van Aalst C, Langereis J, Kamp V, Sluis Eising S, et al. Proteomic profiling of peripheral blood neutrophils identifies two inflammatory phenotypes in stable COPD patients. Respir Res. 2017;18:100 pubmed publisher
	Alaridah N, Lutay N, Tenland E, Rönnholm A, Hallgren O, Puthia M, et al. Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs. J Innate Immun. 2017;9:318-329 pubmed publisher
	Chen L, Fan J, Chen H, Meng Z, Chen Z, Wang P, et al. The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases. Sci Rep. 2014;4:5911 pubmed publisher
	Kopesky P, Tiedemann K, Alkekhia D, Zechner C, Millard B, Schoeberl B, et al. Autocrine signaling is a key regulatory element during osteoclastogenesis. Biol Open. 2014;3:767-76 pubmed publisher
	Al Alwan L, Chang Y, Rousseau S, Martin J, Eidelman D, Hamid Q. CXCL1 inhibits airway smooth muscle cell migration through the decoy receptor Duffy antigen receptor for chemokines. J Immunol. 2014;193:1416-26 pubmed publisher
	Chen L, Qu C, Chen H, Xu L, Qi Q, Luo J, et al. Chinese herbal medicine suppresses invasion-promoting capacity of cancer-associated fibroblasts in pancreatic cancer. PLoS ONE. 2014;9:e96177 pubmed publisher
	Cartwright A, Schmutz C, Askari A, Kuiper J, Middleton J. Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis. Cytokine. 2014;67:53-9 pubmed publisher
	Caccuri F, Giagulli C, Reichelt J, Martorelli D, Marsico S, Bugatti A, et al. Simian immunodeficiency virus and human immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate B cell growth. J Virol. 2014;88:5706-17 pubmed publisher
	Omatsu T, Cepinskas G, Clarson C, Patterson E, Alharfi I, Summers K, et al. CXCL1/CXCL8 (GRO?/IL-8) in human diabetic ketoacidosis plasma facilitates leukocyte recruitment to cerebrovascular endothelium in vitro. Am J Physiol Endocrinol Metab. 2014;306:E1077-84 pubmed publisher
	Liu L, Xie F, Chang K, Li M, Meng Y, Wang X, et al. Hypoxia promotes the proliferation of cervical carcinoma cells through stimulating the secretion of IL-8. Int J Clin Exp Pathol. 2014;7:575-83 pubmed
	Chen C, Chen L, Hsu Y, Liu K, Fan C, Huang T. The endothelin-integrin axis is involved in macrophage-induced breast cancer cell chemotactic interactions with endothelial cells. J Biol Chem. 2014;289:10029-44 pubmed publisher
	Shi G, Han J, Liu G, Hao Y, Ma Y, Li T, et al. Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative pathway in CSF of bacterial meningitis patients. Eur J Immunol. 2014;44:420-30 pubmed publisher
	Infanger D, Cho Y, Lopez B, Mohanan S, Liu S, Gursel D, et al. Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche. Cancer Res. 2013;73:7079-89 pubmed publisher
	Singh J, Farnie G, Bundred N, Simões B, Shergill A, Landberg G, et al. Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms. Clin Cancer Res. 2013;19:643-56 pubmed publisher
	Schulz C, Stoelcker B, Ruhland B, Jentsch N, Steege A. Bronchoepithelial expression of CXCR1 and CXCR2 does not facilitate transepithelial migration of neutrophils. Respiration. 2012;84:108-16 pubmed publisher
	Nieman K, Kenny H, Penicka C, Ladanyi A, Buell Gutbrod R, Zillhardt M, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 2011;17:1498-503 pubmed publisher
	Eikawa S, Ohue Y, Kitaoka K, Aji T, Uenaka A, Oka M, et al. Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6. J Immunol. 2010;185:6734-40 pubmed publisher
	Weiss N, Deboux C, Chaverot N, Miller F, Baron van Evercooren A, Couraud P, et al. IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells. J Neuroimmunol. 2010;223:131-4 pubmed publisher
	Pradhan L, Cai X, Wu S, Andersen N, Martin M, Malek J, et al. Gene expression of pro-inflammatory cytokines and neuropeptides in diabetic wound healing. J Surg Res. 2011;167:336-42 pubmed publisher
	Mintz R, Garty B, Meshel T, Marcus N, Katanov C, Cohen Hillel E, et al. Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients. Immunol Lett. 2010;130:97-106 pubmed publisher
	van der Veen B, Petersen A, Belperio J, Satchell S, Mathieson P, Molema G, et al. Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis. Clin Exp Immunol. 2009;158:143-53 pubmed publisher
	Singh S, Nannuru K, Sadanandam A, Varney M, Singh R. CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion. Br J Cancer. 2009;100:1638-46 pubmed publisher
	Rowe S, Jackson P, Liu G, Hardison M, Livraghi A, Solomon G, et al. Potential role of high-mobility group box 1 in cystic fibrosis airway disease. Am J Respir Crit Care Med. 2008;178:822-31 pubmed publisher
	Goczalik I, Ulbricht E, Hollborn M, Raap M, Uhlmann S, Weick M, et al. Expression of CXCL8, CXCR1, and CXCR2 in neurons and glial cells of the human and rabbit retina. Invest Ophthalmol Vis Sci. 2008;49:4578-89 pubmed publisher
	Gaggar A, Jackson P, Noerager B, O Reilly P, McQuaid D, Rowe S, et al. A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation. J Immunol. 2008;180:5662-9 pubmed
	Lee D, King M. Shear-induced capping of L-selectin on the neutrophil surface during centrifugation. J Immunol Methods. 2007;328:97-105 pubmed
	Tsai W, Hsu H, Lin C, Ho C, Kou Y. Role of interleukin-8 and growth-regulated oncogene-alpha in the chemotactic migration of all-trans retinoic acid-treated promyelocytic leukemic cells toward alveolar epithelial cells. Crit Care Med. 2007;35:879-85 pubmed
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	Kline M, Donovan K, Wellik L, Lust C, Jin W, Moon Tasson L, et al. Cytokine and chemokine profiles in multiple myeloma; significance of stromal interaction and correlation of IL-8 production with disease progression. Leuk Res. 2007;31:591-8 pubmed
	Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck L, et al. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin Immunol. 2006;120:220-31 pubmed
	Haas C, Martinez R, Attia N, Haines G, Campbell P, Koch A. Chemokine receptor expression in rat adjuvant-induced arthritis. Arthritis Rheum. 2005;52:3718-30 pubmed
	Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, et al. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol. 2005;175:6177-89 pubmed
	Malgorzata Goczalik I, Raap M, Weick M, Milenkovic I, Heidmann J, Enzmann V, et al. The activation of IL-8 receptors in cultured guinea pig Müller glial cells is modified by signals from retinal pigment epithelium. J Neuroimmunol. 2005;161:49-60 pubmed
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product information

brand :

R&D Systems

master code :

MAB330

SKU :

MAB330-100

product name :

Human CXCR1/IL-8RA Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human CXCR1/IL-8RA Antibody from R&D Systems is a mouse monoclonal antibody to CXCR1/IL-8RA. This antibody reacts with guinea pig,human,mouse,rabbit,rat. The Human CXCR1/IL-8RA Antibody has been validated for the following applications: Immunohistochemistry,Bioassay,Flow Cytometry,Western Blot,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,Immunocytochemistry,CyTOF-reported.

target :

CXCR1/IL-8RA

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

42705

conjugate :

Unconjugated

dilution :

Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 8-25 ug/mL, Neutralization 0.4-2.0 ug/mL, CyTOF-reported

host :

Mouse

immunogen :

NS0 mouse myeloma cell line transfected with human CXCR1/IL-8 RA, Met1-Leu350, Accession # AAA59159

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Guinea Pig,Human,Mouse,Rabbit,Rat

specificity :

Detects human CXCR1/IL-8 RA transfectants but not the parental cell line. It does not cross-react with human CXCR2.

gene symbol :

CXCR1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of CXCR1/IL-8 RA antibody in Human Blood Granulocytes antibody by Flow Cytometry.

accessionNumbers :

AAA59159

applications :

CyTOF-reported,Bioassay,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,Neutralization,Immunocytochemistry,Functional Assay

extended description :

Clone 42705 was used by HLDA to establish CD designation

USD :

479 USD

product details :

Clone 42705 was used by HLDA to establish CD designation

alt names :

CD128, CD181, CD181 antigen, CDw128aC-C, chemokine (C-X-C motif) receptor 1, CKR-1, CMKAR1, C-X-C chemokine receptor type 1, CXC-R1, CXCR-1, High affinity interleukin-8 receptor A, IL-8 RA, IL-8 receptor type 1, IL-8R A, IL8R1, IL8RA, IL8RAC-C-CKR-1, IL8RBA, interleukin 8 receptor, alpha, interleukin-8 receptor type 1, interleukin-8 receptor type A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage