product summary
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company name :
R&D Systems
product type :
antibody
product name :
4-Hydroxynonenal Antibody
catalog :
MAB3249
quantity :
100 ug (also 25 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
198960
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 108
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500; loading ...; fig 1i
Kasica N, Zhou X, Jester H, Holland C, Ryazanov A, Forshaw T, et al. Homozygous knockout of eEF2K alleviates cognitive deficits in APP/PS1 Alzheimer's disease model mice independent of brain amyloid β pathology. Front Aging Neurosci. 2022;14:959326 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 4a
Dang G, Li T, Yang D, Yang G, Du X, Yang J, et al. T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2. Redox Biol. 2022;50:102257 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 5b
Beaulac H, Gilels F, Zhang J, Jeoung S, White P. Primed to die: an investigation of the genetic mechanisms underlying noise-induced hearing loss and cochlear damage in homozygous Foxo3-knockout mice. Cell Death Dis. 2021;12:682 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 3a
Cho J, Lee J, Kim H, Lee H, Fang Z, Kwon H, et al. Ethyl Acetate Fraction of Amomum villosum var. xanthioides Attenuates Hepatic Endoplasmic Reticulum Stress-Induced Non-Alcoholic Steatohepatitis via Improvement of Antioxidant Capacities. Antioxidants (Basel). 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:250; loading ...; fig s5a
Misra J, Holmes M, T Mirek E, Langevin M, Kim H, Carlson K, et al. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Nucleic Acids Res. 2021;49:5726-5742 pubmed publisher
Joubert M, Ingaramo P, Collins P, D Alessandro M. Astaxanthin improves lipotoxicity, lipid peroxidation and oxidative stress in kidney of sucrose-rich diet-fed rats. J Nutr Biochem. 2025;135:109779 pubmed publisher
Choudhury T, Greskovich S, Girard H, Rao A, Budhathoki Y, Cameron E, et al. Impact of genetic factors on antioxidant rescue of maternal diabetes-associated congenital heart disease. JCI Insight. 2024;9: pubmed publisher
Zhao Z, Chen M, Sun K, Gu X. CD8+ T cell associated scoring model helps prognostic diagnosis and immunotherapy selection in patients with colon adenocarcinoma. Heliyon. 2024;10:e37998 pubmed publisher
Yang X, Bhowmick K, Rao S, Xiang X, Ohshiro K, Amdur R, et al. Aldehydes alter TGF-β signaling and induce obesity and cancer. Cell Rep. 2024;43:114676 pubmed publisher
Karg x131 Gemici E, x15e engelen A, Aks xfc t Y, Akyol O, x15e engiz Erhan S, Bay M, et al. Cerium oxide nanoparticles (nanoceria) pretreatment attenuates cell death in the hippocampus and cognitive dysfunction due to repeated isoflurane anesthesia in newborn rats. Neurotoxicology. 2024;105:82-93 pubmed publisher
Cui Y, Li Y, Xu Y, Liu X, Kang X, Zhu J, et al. SLC7A11 protects luminal A breast cancer cells against ferroptosis induced by CDK4/6 inhibitors. Redox Biol. 2024;76:103304 pubmed publisher
Wu L, Lin H, Li S, Huang Y, Sun Y, Shu S, et al. Macrophage iron dyshomeostasis promotes aging-related renal fibrosis. Aging Cell. 2024;23:e14275 pubmed publisher
Wang P, Ouyang J, Zhou K, Hu D, Zhang S, Zhang A, et al. Olesoxime protects against cisplatin-induced acute kidney injury by attenuating mitochondrial dysfunction. Biomed J. 2024;:100730 pubmed publisher
Agius T, Emsley R, Lyon A, MacArthur M, Kiesworo K, Faivre A, et al. Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21. Nat Commun. 2024;15:1073 pubmed publisher
Bae C, Kim Y, Kwon Y. CU06-1004 alleviates oxidative stress and inflammation on folic acid-induced acute kidney injury in mice. J Pharmacol Sci. 2024;154:77-85 pubmed publisher
Pan X, Huang P, Ali S, Renslo B, Hutchinson T, Erwin N, et al. CRISPR-Cas9 Engineered Extracellular Vesicles for the Treatment of Dominant Progressive Hearing Loss. bioRxiv. 2023;: pubmed publisher
Lee K, Yang C, Shueng P, Wu S, Chen C, Chao Y, et al. Downregulation of TAZ elicits a mitochondrial redox imbalance and ferroptosis in lung epithelial cells exposed to diesel exhaust particles. Ecotoxicol Environ Saf. 2023;266:115555 pubmed publisher
Chen F, Zhan J, Liu M, Mamun A, Huang S, Tao Y, et al. FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses. Int J Biol Sci. 2023;19:4340-4359 pubmed publisher
Tognoloni A, Bartolini D, Pepe M, Di Meo A, Porcellato I, Guidoni K, et al. Platelets Rich Plasma Increases Antioxidant Defenses of Tenocytes via Nrf2 Signal Pathway. Int J Mol Sci. 2023;24: pubmed publisher
Jean Wilson E, Sirpu Natesh N, Ghadermazi P, Pothuraju R, Shanmugam M, Prajapati D, et al. Red cabbage juice-mediated gut microbiota modulation improves intestinal epithelial homeostasis and ameliorates colitis. bioRxiv. 2023;: pubmed publisher
Wang C, Xie L, Xing Y, Liu M, Yang J, Gao N, et al. Iron-overload-induced ferroptosis in mouse cerebral toxoplasmosis promotes brain injury and could be inhibited by Deferiprone. PLoS Negl Trop Dis. 2023;17:e0011607 pubmed publisher
Kong P, Yang M, Wang Y, Yu K, Wu L, Han W. Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury. Redox Biol. 2023;66:102857 pubmed publisher
Choi J, Choi H, Chung J. Icariin Supplementation Suppresses the Markers of Ferroptosis and Attenuates the Progression of Nonalcoholic Steatohepatitis in Mice Fed a Methionine Choline-Deficient Diet. Int J Mol Sci. 2023;24: pubmed publisher
Deng Z, Wang Y, Liu J, Zhang H, Zhou L, Zhao H, et al. WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury. Redox Biol. 2023;65:102826 pubmed publisher
Wen H, Chen J, Zhao B, Wang S, Ma A, Dong H, et al. Repression of ferroptotic cell death by mitochondrial calcium signaling. Res Sq. 2023;: pubmed publisher
Shi J, Wang Q, Wei X, Huo B, Ye J, Yi X, et al. Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis. Mol Med. 2023;29:91 pubmed publisher
Mankowski R, Wohlgemuth S, Bresciani G, Martin A, Arnaoutakis G, Martin T, et al. Intraoperative Hemi-Diaphragm Electrical Stimulation Demonstrates Attenuated Mitochondrial Function without Change in Oxidative Stress in Cardiothoracic Surgery Patients. Antioxidants (Basel). 2023;12: pubmed publisher
Zheng J, Zhang Q, Zhao Z, Qiu Y, Zhou Y, Wu Z, et al. Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m6A-dependent recognition of Nrf2 mRNA mediated by SND1. J Exp Clin Cancer Res. 2023;42:127 pubmed publisher
Yang T, Li Q, Fadoul G, Alraqmany N, Ikonomovic M, Zhang F. Aldo-Keto Reductase 1C15 Characterization and Protection in Ischemic Brain Injury. Antioxidants (Basel). 2023;12: pubmed publisher
Chen C, Yang Y, Guo Y, He J, Chen Z, Qiu S, et al. CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer. Cell Death Dis. 2023;14:271 pubmed publisher
Kahm Y, Kim I, Kim R. RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma. Int J Mol Sci. 2023;24: pubmed publisher
Zha Y, Yang Y, Zhou Y, Ye B, Li H, Liang J. Dietary Evodiamine Inhibits Atherosclerosis-Associated Changes in Vascular Smooth Muscle Cells. Int J Mol Sci. 2023;24: pubmed publisher
Du Y, Li X, Wang T, Zhou L, Li H, Feng L, et al. Cyanidin-3-glucoside inhibits ferroptosis in renal tubular cells after ischemia/reperfusion injury via the AMPK pathway. Mol Med. 2023;29:42 pubmed publisher
Du X, Ma X, Tan Y, Shao F, Li C, Zhao Y, et al. B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis. Signal Transduct Target Ther. 2023;8:103 pubmed publisher
Zhang Q, Li N, Deng L, Jiang X, Zhang Y, Lee L, et al. ACSL1-induced ferroptosis and platinum resistance in ovarian cancer by increasing FSP1 N-myristylation and stability. Cell Death Discov. 2023;9:83 pubmed publisher
Chiu Y, Lin C, Lin C, Yang P, Lo Y, Chen Y, et al. Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson's Disease. Int J Mol Sci. 2023;24: pubmed publisher
Du C, Xu H, Cao C, Cao J, Zhang Y, Zhang C, et al. Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis. elife. 2023;12: pubmed publisher
Sun Y, Demagny H, Fauré A, Pontanari F, Jalil A, Bresciani N, et al. Asparagine protects pericentral hepatocytes during acute liver injury. J Clin Invest. 2023;133: pubmed publisher
Chen Y, Hsu J, Chu C, Chang Y, Fan J, Yang M, et al. Loss of cell-cell adhesion triggers cell migration through Rac1-dependent ROS generation. Life Sci Alliance. 2023;6: pubmed publisher
Mahdi A, Wodaje T, K xf6 vamees O, Tengbom J, Zhao A, Jiao T, et al. The red blood cell as a mediator of endothelial dysfunction in patients with familial hypercholesterolemia and dyslipidemia. J Intern Med. 2023;293:228-245 pubmed publisher
Yang L, Chen Y, Lee J, Chen K, Luh H, Chen Y, et al. Dental Pulp Stem Cell-Derived Conditioned Medium Alleviates Subarachnoid Hemorrhage-Induced Microcirculation Impairment by Promoting M2 Microglia Polarization and Reducing Astrocyte Swelling. Transl Stroke Res. 2023;14:688-703 pubmed publisher
Wu Y, De La Toba E, Dvoretskiy S, Jung R, Kim N, Daniels L, et al. Development of a cell-free strategy to recover aged skeletal muscle after disuse. J Physiol. 2023;601:5011-5031 pubmed publisher
Saemann L, Hoorn F, Georgevici A, Pohl S, Korkmaz Ic xf6 z S, Veres G, et al. Cytokine Adsorber Use during DCD Heart Perfusion Counteracts Coronary Microvascular Dysfunction. Antioxidants (Basel). 2022;11: pubmed publisher
Ban K, Nam G, Kim D, Oh Y, Jun H. Prevention of LPS-Induced Acute Kidney Injury in Mice by Bavachin and Its Potential Mechanisms. Antioxidants (Basel). 2022;11: pubmed publisher
Sze S, Zhang L, Zhang S, Lin K, Ng T, Ng M, et al. Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: . Int J Mol Sci. 2022;23: pubmed publisher
Siriviriyakul P, Sriko J, Somanawat K, Chayanupatkul M, Klaikeaw N, Werawatganon D. Genistein attenuated oxidative stress, inflammation, and apoptosis in L-arginine induced acute pancreatitis in mice. BMC Complement Med Ther. 2022;22:208 pubmed publisher
Li N, Yi X, He Y, Huo B, Chen Y, Zhang Z, et al. Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection. Int J Biol Sci. 2022;18:4118-4134 pubmed publisher
Griffin J, Krolikowski J, Kounga K, Struve J, Keszler A, Lindemer B, et al. Red Light Mitigates the Deteriorating Placental Extracellular Matrix in Late Onset of Preeclampsia and Improves the Trophoblast Behavior. J Pregnancy. 2022;2022:3922368 pubmed publisher
Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, et al. Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy. Redox Biol. 2022;52:102292 pubmed publisher
Wang J, Wang Y, Liu Y, Cai X, Huang X, Fu W, et al. Ferroptosis, a new target for treatment of renal injury and fibrosis in a 5/6 nephrectomy-induced CKD rat model. Cell Death Discov. 2022;8:127 pubmed publisher
Hu Q, Chen H, Shen C, Zhang B, Weng X, Sun X, et al. Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice. Alcohol Clin Exp Res. 2022;46:707-723 pubmed publisher
Bašković M, Krsnik D, Himelreich Peric M, Katusic Bojanac A, Sincic N, Sonicki Z, et al. Astaxanthin Relieves Testicular Ischemia-Reperfusion Injury-Immunohistochemical and Biochemical Analyses. J Clin Med. 2022;11: pubmed publisher
MacLean M, López Díez R, Vasquez C, Gugger P, Schmidt A. Neuronal-glial communication perturbations in murine SOD1G93A spinal cord. Commun Biol. 2022;5:177 pubmed publisher
Moya M, L xf3 pez Valencia L, Garc xed a Bueno B, Orio L. Disinhibition-Like Behavior Correlates with Frontal Cortex Damage in an Animal Model of Chronic Alcohol Consumption and Thiamine Deficiency. Biomedicines. 2022;10: pubmed publisher
Dieguez H, Calanni J, Romeo H, Alaimo A, González Fleitas M, Iaquinandi A, et al. Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration. Cell Death Dis. 2021;12:1128 pubmed publisher
Yang F, Hu A, Guo Y, Wang J, Li D, Wang X, et al. p113 isoform encoded by CUX1 circular RNA drives tumor progression via facilitating ZRF1/BRD4 transactivation. Mol Cancer. 2021;20:123 pubmed publisher
Ren X, Li Y, Zhou Y, Hu W, Yang C, Jing Q, et al. Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis. Redox Biol. 2021;46:102122 pubmed publisher
Wang L, Zhang W, Zou N, Zhang L. Trophoblasts Modulate the Ca2+ Oscillation and Contraction of Myometrial Smooth Muscle Cells by Small Extracellular Vesicle- (sEV-) Mediated Exporting of miR-25-3p during Premature Labor. Oxid Med Cell Longev. 2021;2021:8140667 pubmed publisher
Oke S, Lee K, Papp R, Laviolette S, Hardy D. In Utero Exposure to Δ9-Tetrahydrocannabinol Leads to Postnatal Catch-Up Growth and Dysmetabolism in the Adult Rat Liver. Int J Mol Sci. 2021;22: pubmed publisher
Du J, Wang X, Li Y, Ren X, Zhou Y, Hu W, et al. DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism. Cell Death Dis. 2021;12:705 pubmed publisher
Das D, Paul A, Lahiri A, Adak M, Maity S, Sarkar A, et al. Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules. Redox Biol. 2021;45:102043 pubmed publisher
Koike S, Hsu M, Bettaieb A, Chu B, Matsumoto N, Morisseau C, et al. Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss. Free Radic Biol Med. 2021;172:48-57 pubmed publisher
Fang Z, Kim H, Huang M, Chowdhury K, Li M, Liangpunsakul S, et al. Sestrin Proteins Protect Against Lipotoxicity-Induced Oxidative Stress in the Liver via Suppression of C-Jun N-Terminal Kinases. Cell Mol Gastroenterol Hepatol. 2021;12:921-942 pubmed publisher
Langley M, Ghaisas S, Palanisamy B, Ay M, Jin H, Anantharam V, et al. Characterization of nonmotor behavioral impairments and their neurochemical mechanisms in the MitoPark mouse model of progressive neurodegeneration in Parkinson's disease. Exp Neurol. 2021;341:113716 pubmed publisher
Bruells C, Duschner P, Marx G, Gayan Ramirez G, Frank N, Breuer T, et al. Acute liver injury following acetaminophen administration does not activate atrophic pathways in the mouse diaphragm. Sci Rep. 2021;11:6302 pubmed publisher
Deng H, Yue L, Wang N, Zhou Y, Zhou W, Liu X, et al. Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity. Front Pharmacol. 2020;11:624529 pubmed publisher
Roy B, Palaniyandi S. A role for aldehyde dehydrogenase (ALDH) 2 in angiotensin II-mediated decrease in angiogenesis of coronary endothelial cells. Microvasc Res. 2021;135:104133 pubmed publisher
Jiao Z, Wu Y, Qu S. Fenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system. Cell Death Discov. 2020;6:78 pubmed publisher
Li M, Li C, Ye Z, Huang J, Li Y, Lai W, et al. Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice. J Cell Mol Med. 2020;24:5109-5121 pubmed publisher
Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, et al. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy. Cancer Sci. 2020;111:127-136 pubmed publisher
Oke S, Sohi G, Hardy D. Perinatal protein restriction with postnatal catch-up growth leads to elevated p66Shc and mitochondrial dysfunction in the adult rat liver. Reproduction. 2020;159:27-39 pubmed publisher
Verpoorten S, Sfyri P, Scully D, Mitchell R, Tzimou A, Mougios V, et al. Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis. Acta Physiol (Oxf). 2020;228:e13395 pubmed publisher
Tendilla Beltran H, Meneses Prado S, Vazquez Roque R, Tapia Rodríguez M, Vázquez Hernández A, Coatl Cuaya H, et al. Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion. J Neurosci. 2019;39:8584-8599 pubmed publisher
Siriviriyakul P, Chingchit T, Klaikeaw N, Chayanupatkul M, Werawatganon D. Effects of curcumin on oxidative stress, inflammation and apoptosis in L-arginine induced acute pancreatitis in mice. Heliyon. 2019;5:e02222 pubmed publisher
Mao X, Zhou H, Jin W. Ferroptosis Induction in Pentylenetetrazole Kindling and Pilocarpine-Induced Epileptic Seizures in Mice. Front Neurosci. 2019;13:721 pubmed publisher
de Dios C, Bartolessis I, Roca Agujetas V, Barbero Camps E, Mari M, Morales A, et al. Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress. Redox Biol. 2019;26:101283 pubmed publisher
Orczykowski M, Calderazzo S, Shobin E, Pessina M, Oblak A, Finklestein S, et al. Cell based therapy reduces secondary damage and increases extent of microglial activation following cortical injury. Brain Res. 2019;1717:147-159 pubmed publisher
Liang F, Emeriaud G, Rassier D, Shang D, Gusev E, Hussain S, et al. Mechanical ventilation causes diaphragm dysfunction in newborn lambs. Crit Care. 2019;23:123 pubmed publisher
Chen X, Wang K, Cederbaum A, Lu Y. Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice. Biochem Biophys Res Commun. 2019;512:119-124 pubmed publisher
Zhang M, Wang S, Wang Y, Zhang Y, Ming Hao C, Harris R. Renal Medullary Interstitial COX-2 (Cyclooxygenase-2) Is Essential in Preventing Salt-Sensitive Hypertension and Maintaining Renal Inner Medulla/Papilla Structural Integrity. Hypertension. 2018;72:1172-1179 pubmed publisher
Sfyri P, Yuldasheva N, Tzimou A, Giallourou N, Crispi V, Aburima A, et al. Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity. Free Radic Biol Med. 2018;129:504-519 pubmed publisher
Lee H, Lim Y. Tocotrienol-rich fraction supplementation reduces hyperglycemia-induced skeletal muscle damage through regulation of insulin signaling and oxidative stress in type 2 diabetic mice. J Nutr Biochem. 2018;57:77-85 pubmed publisher
Barra N, Vanduzer T, Holloway A, Hardy D. Maternal Nicotine Exposure Leads to Augmented Expression of the Antioxidant Adipose Tissue Triglyceride Lipase Long-Term in the White Adipose of Female Rat Offspring. Toxicol Sci. 2018;164:72-84 pubmed publisher
Chatterjee A, Zhu Y, Tong Q, Kosmacek E, Lichter E, Oberley Deegan R. The Addition of Manganese Porphyrins during Radiation Inhibits Prostate Cancer Growth and Simultaneously Protects Normal Prostate Tissue from Radiation Damage. Antioxidants (Basel). 2018;7: pubmed publisher
Gemechu J, Sharma A, Yu D, Xie Y, Merkel O, Moszczynska A. Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats. Sci Rep. 2018;8:1517 pubmed publisher
Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, et al. Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice. J Biol Chem. 2018;293:1596-1609 pubmed publisher
Allison S, Chen Y, Petrovic N, Zhang J, Bourget K, Mackenzie P, et al. Activation of ALDH1A1 in MDA-MB-468 breast cancer cells that over-express CYP2J2 protects against paclitaxel-dependent cell death mediated by reactive oxygen species. Biochem Pharmacol. 2017;143:79-89 pubmed publisher
Hambright W, Fonseca R, Chen L, Na R, Ran Q. Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration. Redox Biol. 2017;12:8-17 pubmed publisher
Shin J, Yang S, Lim Y. Gamma-tocopherol supplementation ameliorated hyper-inflammatory response during the early cutaneous wound healing in alloxan-induced diabetic mice. Exp Biol Med (Maywood). 2017;242:505-515 pubmed publisher
Seo J, Singh N, Ottesen E, Sivanesan S, Shishimorova M, Singh R. Oxidative Stress Triggers Body-Wide Skipping of Multiple Exons of the Spinal Muscular Atrophy Gene. PLoS ONE. 2016;11:e0154390 pubmed publisher
Cielen N, Heulens N, Maes K, Carmeliet G, Mathieu C, Janssens W, et al. Vitamin D deficiency impairs skeletal muscle function in a smoking mouse model. J Endocrinol. 2016;229:97-108 pubmed publisher
Greco T, Glenn T, Hovda D, Prins M. Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity. J Cereb Blood Flow Metab. 2016;36:1603-13 pubmed publisher
Zhang Y, Yang C, Yuan G, Wang Z, Cui W, Li R. Sulindac attenuates valproic acid-induced oxidative stress levels in primary cultured cortical neurons and ameliorates repetitive/stereotypic-like movement disorders in Wistar rats prenatally exposed to valproic acid. Int J Mol Med. 2015;35:263-70 pubmed publisher
Zheng R, Dragomir A, Mishin V, Richardson J, Heck D, Laskin D, et al. Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats. Toxicol Appl Pharmacol. 2014;279:43-52 pubmed publisher
Gárate I, Garcia Bueno B, Madrigal J, Caso J, Alou L, Gómez Lus M, et al. Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress. J Neuroinflammation. 2014;11:8 pubmed publisher
Holloway A, Salomon A, Soares M, Garnier V, Raha S, Sergent F, et al. Characterization of the adverse effects of nicotine on placental development: in vivo and in vitro studies. Am J Physiol Endocrinol Metab. 2014;306:E443-56 pubmed publisher
Weiss D, Casale G, Koutakis P, Nella A, Swanson S, Zhu Z, et al. Oxidative damage and myofiber degeneration in the gastrocnemius of patients with peripheral arterial disease. J Transl Med. 2013;11:230 pubmed publisher
Bufalino M, DeVeale B, van der Kooy D. The asymmetric segregation of damaged proteins is stem cell-type dependent. J Cell Biol. 2013;201:523-30 pubmed publisher
Margaritis M, Antonopoulos A, Digby J, Lee R, Reilly S, Coutinho P, et al. Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels. Circulation. 2013;127:2209-21 pubmed publisher
Ghosh A, Kanthasamy A, Joseph J, Anantharam V, Srivastava P, Dranka B, et al. Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. J Neuroinflammation. 2012;9:241 pubmed publisher
Galloway C, Lee H, Nejjar S, Jhun B, Yu T, Hsu W, et al. Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress. Diabetes. 2012;61:2093-104 pubmed publisher
Wang Z, Dou X, Gu D, Shen C, Yao T, Nguyen V, et al. 4-Hydroxynonenal differentially regulates adiponectin gene expression and secretion via activating PPAR? and accelerating ubiquitin-proteasome degradation. Mol Cell Endocrinol. 2012;349:222-31 pubmed publisher
Moszczynska A, Yamamoto B. Methamphetamine oxidatively damages parkin and decreases the activity of 26S proteasome in vivo. J Neurochem. 2011;116:1005-17 pubmed publisher
Yano M, Watanabe K, Yamamoto T, Ikeda K, Senokuchi T, Lu M, et al. Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice. J Biol Chem. 2011;286:3992-4002 pubmed publisher
Walson K, Tang M, Glumac A, Alexander H, Manole M, Ma L, et al. Normoxic versus hyperoxic resuscitation in pediatric asphyxial cardiac arrest: effects on oxidative stress. Crit Care Med. 2011;39:335-43 pubmed publisher
Brynskikh A, Zhao Y, Mosley R, Li S, Boska M, Klyachko N, et al. Macrophage delivery of therapeutic nanozymes in a murine model of Parkinson's disease. Nanomedicine (Lond). 2010;5:379-96 pubmed publisher
Straface E, Vona R, Gambardella L, Ascione B, Marino M, Bulzomi P, et al. Cell sex determines anoikis resistance in vascular smooth muscle cells. FEBS Lett. 2009;583:3448-54 pubmed publisher
Margutti P, Matarrese P, Conti F, Colasanti T, Delunardo F, Capozzi A, et al. Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis. Blood. 2008;111:4559-70 pubmed
product information
brand :
R&D Systems
master code :
MAB3249
SKU :
MAB3249
product name :
4-Hydroxynonenal Antibody
unit size :
100 ug (also 25 ug)
seo description :
The 4-Hydroxynonenal Antibody from R&D Systems is a mouse monoclonal antibody to 4-Hydroxynonenal. This antibody reacts with equine,human,insect - drosophila,mouse,multi-species,ovine,rat,transgenic mouse,xenograft. The 4-Hydroxynonenal Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Flow Cytometry,IHC/IF,Simple Western,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.
target :
4-Hydroxynonenal
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
198960
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Simple Western 5 ug/mL, Immunohistochemistry 0.1-25 ug/mL
host :
Mouse
immunogen :
KLH-coupled 4-Hydroxynonenal
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Equine,Human,Insect - Drosophila,Mouse,Multi-Species,Ovine,Rat,Transgenic Mouse,Xenograft
specificity :
Detects 4-Hydroxynonenal adducts of histidine residues. No cross-reactivity with nitrotyrosine, formaldehyde, glutaraldehyde, or 4-hydroxy hexenaldehyde adducts is observed.
top caption :
Detection of Human 4-Hydroxynonenal antibody by Western Blot.
applications :
IHC/IF,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Simple Western,Immunocytochemistry
USD :
469 USD
alt names :
(2E)-4-Hydroxy-2-nonenal, 2-Nonenal, 4-hydroxy-, (2E,4R)-, 4 HNE, 4Hydroxynonenal, 4-hydroxy-trans-2-nonenal, HNE
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.