Carboxymethyl Lysine Antibody | R&D Systems MAB3247 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Carboxymethyl Lysine Antibody

catalog :

MAB3247

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

318003

application :

western blot, immunohistochemistry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 16

Reference
Pino Ramos L, Farias D, Olivares Caro L, Mitsi C, Mardones C, Echeverría J, et al. Chilean papaya (Vasconcellea pubescens A. DC.) residues as a source of bioactive compounds: Chemical composition, antioxidant capacity, and antiglycation effects. Heliyon. 2024;10:e38837 pubmed publisher
Rossi G, Jensen A, Ng S, Yin Z, Li A, Misra A, et al. Advanced glycation end product (AGE) targeting antibody SIWA318H is efficacious in preclinical models for pancreatic cancer. Sci Rep. 2023;13:16953 pubmed publisher
Susarla G, Kataria P, Kundu A, D Silva P. Saccharomyces cerevisiae DJ-1 paralogs maintain genome integrity through glycation repair of nucleic acids and proteins. elife. 2023;12: pubmed publisher
Lucy T, Mamun Or Rashid A, Yagi M, Yonei Y. Serial Passaging of RAW 264.7 Cells Modulates Intracellular AGE Formation and Downregulates RANKL-Induced In Vitro Osteoclastogenesis. Int J Mol Sci. 2022;23: pubmed publisher
Dieguez H, Calanni J, Romeo H, Alaimo A, González Fleitas M, Iaquinandi A, et al. Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration. Cell Death Dis. 2021;12:1128 pubmed publisher
Senatus L, López Díez R, Egaña Gorroño L, Liu J, Hu J, Daffu G, et al. RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism. JCI Insight. 2020;5: pubmed publisher
Mastrocola R, Ferrocino I, Liberto E, Chiazza F, Cento A, Collotta D, et al. Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study. J Nutr Biochem. 2018;55:185-199 pubmed publisher
Benetti E, Mastrocola R, Chiazza F, Nigro D, D Antona G, Bordano V, et al. Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice. PLoS ONE. 2018;13:e0189707 pubmed publisher
Avila F, Schmeda Hirschmann G, Silva E. The Major Chromophore Arising from Glucose Degradation and Oxidative Stress Occurrence during Lens Proteins Glycation Induced by Glucose. Molecules. 2017;23: pubmed publisher
Jang S, Kwon D, Kwon K, Park C. Generation and characterization of mouse knockout for glyoxalase 1. Biochem Biophys Res Commun. 2017;490:460-465 pubmed publisher
Mastrocola R, Collino M, Nigro D, Chiazza F, D Antona G, Aragno M, et al. Accumulation of advanced glycation end-products and activation of the SCAP/SREBP Lipogenetic pathway occur in diet-induced obese mouse skeletal muscle. PLoS ONE. 2015;10:e0119587 pubmed publisher
Talaei F, Van Praag V, Shishavan M, Landheer S, Buikema H, Henning R. Increased protein aggregation in Zucker diabetic fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide. BMC Cell Biol. 2014;15:1 pubmed publisher
Chen C, Abell A, Moon Y, Kim K. An advanced glycation end product (AGE)-receptor for AGEs (RAGE) axis restores adipogenic potential of senescent preadipocytes through modulation of p53 protein function. J Biol Chem. 2012;287:44498-507 pubmed publisher
Chow J, Simionescu D, Warner H, Wang B, Patnaik S, Liao J, et al. Mitigation of diabetes-related complications in implanted collagen and elastin scaffolds using matrix-binding polyphenol. Biomaterials. 2013;34:685-95 pubmed publisher
Ni J, Yuan X, Gu J, Yue X, Gu X, Nagaraj R, et al. Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration. Mol Cell Proteomics. 2009;8:1921-33 pubmed publisher
Shapiro B, Owan T, Mohammed S, Meyer D, Mills L, Schalkwijk C, et al. Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines. Circulation. 2008;118:1002-10 pubmed publisher

product information

master code :

MAB3247

SKU :

MAB3247

product name :

Carboxymethyl Lysine Antibody

unit size :

100 ug (also 25 ug)

description :

The Carboxymethyl Lysine Antibody from R&D Systems is a mouse monoclonal antibody to Carboxymethyl Lysine. This antibody reacts with bovine,canine,mouse,multi-species,n/a,plant,yeast. The Carboxymethyl Lysine Antibody has been validated for the following applications: ELISA Control,Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen.

target :

Carboxymethyl Lysine

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

318003

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Carboxymethyl Lysine-modified Keyhole Limpet Hemocyanin (KLH)

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Bovine,Canine,Mouse,Multi-Species,N/A,Plant,Yeast

specificity :

Detects Carboxymethyl Lysine adducts on proteins in Western blots. In Western blots, no cross-reactivity with carboxyethyl lysine adducts is observed.

top caption :

Detection of CML-adducted Protein antibody by Western Blot.

applications :

ELISA Control,Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen

USD :

469 USD

alt names :

CML

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage