product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human PDGF R alpha Antibody
catalog :
MAB322-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
459 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
35248
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 20
Reference
Wei S, Huang Y, Hsieh M, Lin Y, Shyu W, Chen H, et al. Atypical chemokine receptor ACKR3/CXCR7 controls postnatal vasculogenesis and arterial specification by mesenchymal stem cells via Notch signaling. Cell Death Dis. 2020;11:307 pubmed publisher
Oldershaw R, Owens W, Sutherland R, Linney M, Liddle R, Magana L, et al. Human cardiac mesenchymal stem cell like cells, a novel cell population with therapeutic potential. Stem Cells Dev. 2019;: pubmed publisher
Fujino S, Miyoshi N, Ohue M, Takahashi Y, Yasui M, Hata T, et al. Platelet‑derived growth factor receptor‑β gene expression relates to recurrence in colorectal cancer. Oncol Rep. 2018;39:2178-2184 pubmed publisher
Moroncini G, Cuccioloni M, Mozzicafreddo M, Pozniak K, Grieco A, Paolini C, et al. Characterization of binding and quantification of human autoantibodies to PDGFR? using a biosensor-based approach. Anal Biochem. 2017;528:26-33 pubmed publisher
Wu Y, Prager A, Boos S, Resch M, Brizic I, Mach M, et al. Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry. PLoS Pathog. 2017;13:e1006281 pubmed publisher
Yang J, Lee H, Seo J, Park J, Gelman I, Lo E, et al. Structural environment built by AKAP12+ colon mesenchymal cells drives M2 macrophages during inflammation recovery. Sci Rep. 2017;7:42723 pubmed publisher
Douvaras P, Rusielewicz T, Kim K, Haines J, CASACCIA P, Fossati V. Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes. Int J Mol Sci. 2016;17: pubmed publisher
Yu D, Makkar G, Strickland D, Blanpied T, Stumpo D, Blackshear P, et al. Myristoylated Alanine-Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation. J Am Heart Assoc. 2015;4:e002255 pubmed publisher
Cao X, Kaneko T, Li J, Liu A, Voss C, Li S. A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration. Nat Commun. 2015;6:7721 pubmed publisher
Palomero J, Vegliante M, Rodr guez M, Eguileor A, Castellano G, Planas Rigol E, et al. SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in mantle cell lymphoma. Blood. 2014;124:2235-47 pubmed publisher
Roach E, Chakrabarti R, Park N, Keats E, Yip J, Chan N, et al. Intrinsic regulation of hemangioma involution by platelet-derived growth factor. Cell Death Dis. 2012;3:e328 pubmed publisher
Prignano F, Campolmi P, Bonan P, Ricceri F, Cannarozzo G, Troiano M, et al. Fractional CO2 laser: a novel therapeutic device upon photobiomodulation of tissue remodeling and cytokine pathway of tissue repair. Dermatol Ther. 2009;22 Suppl 1:S8-15 pubmed publisher
Li R, Maminishkis A, Wang F, Miller S. PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines. Invest Ophthalmol Vis Sci. 2007;48:5722-32 pubmed
Ball S, Shuttleworth C, Kielty C. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J Cell Biol. 2007;177:489-500 pubmed
Zhang Y, Taveggia C, MELENDEZ VASQUEZ C, Einheber S, Raine C, Salzer J, et al. Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation. J Neurosci. 2006;26:12174-85 pubmed
Wilson H, Scolding N, Raine C. Co-expression of PDGF alpha receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions. J Neuroimmunol. 2006;176:162-73 pubmed
Faraone D, Aguzzi M, Ragone G, Russo K, Capogrossi M, Facchiano A. Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells. Blood. 2006;107:1896-902 pubmed
Kübler H, van Randenborgh H, Treiber U, Wutzler S, Battistel C, Lehmer A, et al. In vitro cytotoxic effects of imatinib in combination with anticancer drugs in human prostate cancer cell lines. Prostate. 2005;63:385-94 pubmed
Nagineni C, Kutty V, Detrick B, Hooks J. Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J Cell Physiol. 2005;203:35-43 pubmed
Luyt K, Varadi A, Halfpenny C, Scolding N, Molnar E. Metabotropic glutamate receptors are expressed in adult human glial progenitor cells. Biochem Biophys Res Commun. 2004;319:120-9 pubmed
product information
brand :
R&D Systems
master code :
MAB322
SKU :
MAB322-100
product name :
Human PDGF R alpha Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The Human PDGF R alpha Antibody from R&D Systems is a mouse monoclonal antibody to PDGFR alpha. This antibody reacts with human,mouse. The Human PDGF R alpha Antibody has been validated for the following applications: Neutralization,Flow Cytometry,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry.
target :
PDGF R alpha
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
35248
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Immunohistochemistry 8-25 ug/mL, Neutralization
host :
Mouse
immunogen :
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human PDGF R alpha
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
specificity :
Detects human PDGF R alpha in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human PDGF R▀ or recombinant mouse PDGF R alpha is observed.
gene symbol :
PDGFRA
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Cell Proliferation Induced by PDGF-AA and Neutralization by Human PDGF Ra Antibody.
applications :
Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry
USD :
459 USD
alt names :
alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a, CD140a antigen, EC 2.7.10, EC 2.7.10.1, MGC74795, PDGFR alpha, PDGFR2, PDGFRA, PDGFRA/BCR fusion, PDGF-R-alpha, platelet-derived growth factor receptor, alpha polypeptide, rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein, RHEPDGFRA
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.