product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse/Rat PRL-3 Antibody
catalog :
MAB3219
quantity :
100 ug (also 25 ug)
price :
439 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
334402
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 7
Reference
Jolly J, Cheatham T, Blackburn J. Phosphatase and Pseudo-Phosphatase Functions of Phosphatase of Regenerating Liver 3 (PRL-3) Are Insensitive to Divalent Metals In Vitro. ACS Omega. 2023;8:30578-30589 pubmed publisher
Smith C, Kihn K, Williamson Z, Chow K, Hersh L, Korotkov K, et al. Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3. PLoS ONE. 2023;18:e0285964 pubmed publisher
Lazo J, Sharlow E, Cornelison R, Hart D, Llaneza D, Mendelson A, et al. Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer. Biomolecules. 2021;11: pubmed publisher
Trenkmann M, Brock M, Gay R, Michel B, Gay S, Huber L. Tumor necrosis factor ?-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-?B signaling. Arthritis Rheum. 2013;65:916-27 pubmed publisher
Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Watanabe M. Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma. Int J Cancer. 2010;127:543-54 pubmed publisher
Wang Z, He Y, Cai S, Zhan W, Li Z, Zhu B, et al. Expression and prognostic impact of PRL-3 in lymph node metastasis of gastric cancer: its molecular mechanism was investigated using artificial microRNA interference. Int J Cancer. 2008;123:1439-47 pubmed publisher
Daouti S, Li W, Qian H, Huang K, Holmgren J, Levin W, et al. A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage. Cancer Res. 2008;68:1162-9 pubmed publisher
product information
master code :
MAB3219
SKU :
MAB3219
product name :
Human/Mouse/Rat PRL-3 Antibody
unit size :
100 ug (also 25 ug)
description :
The Human/Mouse/Rat PRL-3 Antibody from R&D Systems is a mouse monoclonal antibody to PRL-3/PTP4A3. This antibody reacts with human,mouse,rat. The Human/Mouse/Rat PRL-3 Antibody has been validated for the following applications: Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin.
target :
PRL-3/PTP4A3
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
334402
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant human PRL-3, Ala2-Met173, Accession # O75365
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Rat
specificity :
Detects endogenous human, mouse and rat PRL-3 in Western blots. In Western blots, this antibody does not cross-react with recombinant human PRL-1 or PRL-2.
gene symbol :
PTP4A3
top caption :
Detection of Human/Mouse/Rat PRL-3 antibody by Western Blot.
accessionNumbers :
O75365
applications :
Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin
USD :
439 USD
alt names :
PRL3, PRL3EC 3.1.3.48, PRL-3potentially prenylated protein tyrosine phosphatase, PRL-Rprotein tyrosine phosphatase type IVA 3, protein tyrosine phosphatase type IVA, member 3, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PTP4A3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.