Human/Primate IL-17/IL-17A Antibody | R&D Systems MAB317-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Primate IL-17/IL-17A Antibody

catalog :

MAB317-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

519 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

41809

reactivity :

human, mouse

application :

ELISA, immunohistochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 27

Reference
Park M, Park Y, Choi J, Baek J, Jeong H, Na H, et al. Establishment of a humanized animal model of systemic sclerosis in which T helper-17 cells from patients with systemic sclerosis infiltrate and cause fibrosis in the lungs and skin. Exp Mol Med. 2022;54:1577-1585 pubmed publisher
Gorchs L, Ahmed S, Mayer C, Knauf A, Fernández Moro C, Svensson M, et al. The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity. Sci Rep. 2020;10:17444 pubmed publisher
Toledo N, Li H, Omange R, Dacoba T, Crecente Campo J, Schalk D, et al. Cervico-Vaginal Inflammatory Cytokine and Chemokine Responses to Two Different SIV Immunogens. Front Immunol. 2020;11:1935 pubmed publisher
Zheng W, Li L, Zhao D, Wang O, Jiang Y, Xia W, et al. A novel variant in AIRE causing a rare, non‑classical autoimmune polyendocrine syndrome type 1. Mol Med Rep. 2020;22:1285-1294 pubmed publisher
Yan J, Pandey S, Barnes B, Turner J, Abraham C. T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation. Cell Rep. 2020;31:107820 pubmed publisher
Haug V, Kollar B, Tasigiorgos S, Endo Y, Kauke M, Safi A, et al. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours. Transplantation. 2020;104:e260-e270 pubmed publisher
Liao Y, Zhao J, Bulek K, Tang F, Chen X, Cai G, et al. Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. Nat Commun. 2020;11:900 pubmed publisher
Chamcheu J, Esnault S, Adhami V, Noll A, Banang Mbeumi S, Roy T, et al. Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models. Cells. 2019;8: pubmed publisher
Jhun J, Lee S, Lee S, Kim H, Jung E, Kim D, et al. Serial Monitoring of Immune Markers Being Represented Regulatory T Cell/T Helper 17 Cell Ratio: Indicating Tolerance for Tapering Immunosuppression after Liver Transplantation. Front Immunol. 2018;9:352 pubmed publisher
Lv R, Zhao J, Lei M, Xiao D, Yu Y, Xie J. IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3. Cell Physiol Biochem. 2017;42:1961-1972 pubmed publisher
Brencicova E, Jagger A, Evans H, Georgouli M, Laios A, Attard Montalto S, et al. Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma. PLoS ONE. 2017;12:e0175712 pubmed publisher
Hull D, Cooksley H, Chokshi S, Williams R, Abraham S, Taylor P. Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis. Arthritis Res Ther. 2016;18:303 pubmed publisher
Metzler B, Gfeller P, Guinet E. Restricting Glutamine or Glutamine-Dependent Purine and Pyrimidine Syntheses Promotes Human T Cells with High FOXP3 Expression and Regulatory Properties. J Immunol. 2016;196:3618-30 pubmed publisher
Schminke B, Trautmann S, Mai B, Miosge N, Blaschke S. Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage. Eur J Immunol. 2016;46:440-5 pubmed publisher
Todd J, Simpson P, Estis J, Torres V, Wub A. Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays. Cytokine. 2013;64:660-5 pubmed publisher
Nakamura Y, Ishiguro A, Miyakawa S. RNA plasticity and selectivity applicable to therapeutics and novel biosensor development. Genes Cells. 2012;17:344-64 pubmed publisher
Chang Y, Al Alwan L, Risse P, Roussel L, Rousseau S, Halayko A, et al. TH17 cytokines induce human airway smooth muscle cell migration. J Allergy Clin Immunol. 2011;127:1046-53.e1-2 pubmed publisher
Mabry R, Lewis K, Moore M, McKernan P, Bukowski T, Bontadelli K, et al. Engineering of stable bispecific antibodies targeting IL-17A and IL-23. Protein Eng Des Sel. 2010;23:115-27 pubmed publisher
Heo Y, Joo Y, Oh H, Park M, Heo Y, Cho M, et al. IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients. Immunol Lett. 2010;127:150-6 pubmed publisher
Zrioual S, Ecochard R, Tournadre A, Lenief V, Cazalis M, Miossec P. Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes. J Immunol. 2009;182:3112-20 pubmed publisher
Rahmoun M, Moles J, Pedretti N, Mathieu M, Fremaux I, Raison Peyron N, et al. Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils. J Invest Dermatol. 2009;129:671-81 pubmed publisher
Rickel E, Siegel L, Yoon B, Rottman J, Kugler D, Swart D, et al. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 2008;181:4299-310 pubmed
Zrioual S, Toh M, Tournadre A, Zhou Y, Cazalis M, Pachot A, et al. IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. J Immunol. 2008;180:655-63 pubmed
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Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, et al. Ultrasensitive flow-based immunoassays using single-molecule counting. Clin Chem. 2007;53:1990-5 pubmed
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, et al. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol. 2005;175:6177-89 pubmed
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product information

brand :

R&D Systems

master code :

MAB317

SKU :

MAB317-100

product name :

Human/Primate IL-17/IL-17A Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human/Primate IL-17/IL-17A Antibody from R&D Systems is a mouse monoclonal antibody to IL-17/IL-17A. This antibody reacts with human,mouse,primate. The Human/Primate IL-17/IL-17A Antibody has been validated for the following applications: ELISA Development,ELISA Development (Capture),Luminex Development,Flow Cytometry,Neutralization,ELISA Capture,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunoprecipitation,ELISA Capture (Matched Antibody Pair),Dual RNAscope ISH-IHC Compatible.

target :

IL-17/IL-17A

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

41809

conjugate :

Unconjugated

dilution :

Immunohistochemistry 5-25 ug/mL, Immunoprecipitation 3 ug/100 ug cell lysate, Neutralization 1-3 ug/mL, Dual RNAscope ISH-IHC 3-25 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL

host :

Mouse

immunogen :

E. coli -derived recombinant human IL-17, Ile20-Ala155, Accession # Q16552

isotype :

IgG2b

purity :

Protein A or G purified from ascites

species :

Human,Mouse,Primate

specificity :

Detects human and primate IL-17 in direct ELISAs. In direct ELISAs, approximately 12% cross-reactivity with recombinant canine IL-17 is observed and 25%-50% reactivity with recombinant human (rh) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant mouse IL-17, rhIL-17B, rhIL-17C, rhIL-17D, rhIL-17E, or rhIL-17F is observed.

gene symbol :

IL17A

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

IL-17/IL-17A antibody in Human Crohn's Disease Intestine by Immunohistochemistry (IHC-P).

accessionNumbers :

Q16552

applications :

Immunoprecipitation,ELISA Capture (Matched Antibody Pair),Dual RNAscope ISH-IHC Compatible,ELISA Development,ELISA Development (Capture),Luminex Development,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Neutralization,ELISA Capture

USD :

519 USD

alt names :

CTLA8, CTLA-8, CTLA8cytotoxic T-lymphocyte-associated serine esterase 8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL17A, IL-17A, IL-17Acytotoxic T-lymphocyte-associated protein 8, IL-17CTLA-8, IL17interleukin-17A, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), interleukin 17A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage