This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse CXCL12/SDF-1 Antibody
catalog :
MAB310
quantity :
100 ug (also 25 ug, 500 ug)
price :
369 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
79014
reactivity :
human, mouse
application :
immunohistochemistry, neutralization, blocking or activating experiments
citations: 39
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; 25 ug/ml; loading ...; fig 5a
Zheng J, Qu D, Wang C, Ding L, Zhou W. Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling. BMC Pregnancy Childbirth. 2020;20:87 pubmed publisher
  • immunohistochemistry; human; 1:600; loading ...; fig 6
Hira V, Wormer J, Kakar H, Breznik B, van der Swaan B, Hulsbos R, et al. Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins. J Histochem Cytochem. 2018;66:155-173 pubmed publisher
  • blocking or activating experiments; mouse; fig 4a
Kasagi Y, Harada Y, Morodomi Y, Iwai T, Saito S, Yoshida K, et al. Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix-Directed Spheroid Formation. Cancer Res. 2016;76:347-57 pubmed publisher
Westendorp B, Büller N, Karpus O, van Dop W, Koster J, Versteeg R, et al. Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response. Cell Mol Gastroenterol Hepatol. 2018;5:67-82.e1 pubmed publisher
Isaacson B, Hadad T, Glasner A, Gur C, Granot Z, Bachrach G, et al. Stromal Cell-Derived Factor 1 Mediates Immune Cell Attraction upon Urinary Tract Infection. Cell Rep. 2017;20:40-47 pubmed publisher
Chen X, Yu T, Zhang J, Li Y, Chen H, Yang G, et al. CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis. Oncogene. 2017;36:5045-5057 pubmed publisher
Guo Q, Minnier J, Burchard J, Chiotti K, Spellman P, Schedin P. Physiologically activated mammary fibroblasts promote postpartum mammary cancer. JCI Insight. 2017;2:e89206 pubmed publisher
Hira V, Verbovšek U, Breznik B, Srdič M, Novinec M, Kakar H, et al. Cathepsin K cleavage of SDF-1? inhibits its chemotactic activity towards glioblastoma stem-like cells. Biochim Biophys Acta Mol Cell Res. 2017;1864:594-603 pubmed publisher
Sun J, Jiao K, Niu L, Jiao Y, Song Q, Shen L, et al. Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration. Biomaterials. 2017;113:203-216 pubmed publisher
Deng Y, Cheng J, Fu B, Liu W, Chen G, Zhang Q, et al. Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells. Oncogene. 2017;36:1090-1101 pubmed publisher
Janssens R, Mortier A, Boff D, Vanheule V, Gouwy M, Franck C, et al. Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo. Oncotarget. 2016;7:62439-62459 pubmed publisher
Goto Y, Aoyama M, Sekiya T, Kakita H, Waguri Nagaya Y, Miyazawa K, et al. CXCR4+ CD45- Cells are Niche Forming for Osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 Signaling Pathways in Bone Marrow. Stem Cells. 2016;34:2733-2743 pubmed publisher
Feng Y, Guo H, Yuan F, Shen M. Lipopolysaccharide Promotes Choroidal Neovascularization by Up-Regulation of CXCR4 and CXCR7 Expression in Choroid Endothelial Cell. PLoS ONE. 2015;10:e0136175 pubmed publisher
Lin Y, Yet S, Hsu Y, Wang G, Hung S. Mesenchymal Stem Cells Ameliorate Atherosclerotic Lesions via Restoring Endothelial Function. Stem Cells Transl Med. 2015;4:44-55 pubmed publisher
Beck T, Gomes A, Cyster J, Pereira J. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. J Exp Med. 2014;211:2567-81 pubmed publisher
. Vitamin D promotes vascular regeneration. Circulation. 2014;130:976-86 pubmed publisher
Wurster T, Tegtmeyer R, Borst O, Rath D, Geisler T, Gawaz M, et al. Platelet expression of stromal cell-derived factor-1 is associated with the degree of valvular aortic stenosis. PLoS ONE. 2014;9:e97405 pubmed publisher
Zgraggen S, Huggenberger R, Kerl K, Detmar M. An important role of the SDF-1/CXCR4 axis in chronic skin inflammation. PLoS ONE. 2014;9:e93665 pubmed publisher
Fleige H, Ravens S, Moschovakis G, Bölter J, Willenzon S, Sutter G, et al. IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med. 2014;211:643-51 pubmed publisher
Mocco J, Afzal A, Ansari S, Wolfe A, Caldwell K, Connolly E, et al. SDF1-a facilitates Lin-/Sca1+ cell homing following murine experimental cerebral ischemia. PLoS ONE. 2014;9:e85615 pubmed publisher
Smith A, Bowers S, Stratman A, Davis G. Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions. PLoS ONE. 2013;8:e85147 pubmed publisher
O Boyle G, Swidenbank I, Marshall H, Barker C, Armstrong J, White S, et al. Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070. Br J Cancer. 2013;108:1634-40 pubmed publisher
Yang Q, Kim D, Kaucher A, Oatley M, Oatley J. CXCL12-CXCR4 signaling is required for the maintenance of mouse spermatogonial stem cells. J Cell Sci. 2013;126:1009-20 pubmed publisher
Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, et al. Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment. Am J Pathol. 2010;177:2268-77 pubmed publisher
Wei L, Kanbe K, Lee M, Wei X, Pei M, Sun X, et al. Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation. Dev Biol. 2010;341:236-45 pubmed publisher
Kollmar O, Rupertus K, Scheuer C, Nickels R, Haberl G, Tilton B, et al. CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1. Int J Cancer. 2010;126:1302-15 pubmed publisher
Ouwehand K, Santegoets S, Bruynzeel D, Scheper R, de Gruijl T, Gibbs S. CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis. Eur J Immunol. 2008;38:3050-9 pubmed publisher
Meiron M, Zohar Y, Anunu R, Wildbaum G, Karin N. CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells. J Exp Med. 2008;205:2643-55 pubmed publisher
Shaked Y, Henke E, Roodhart J, Mancuso P, Langenberg M, Colleoni M, et al. Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell. 2008;14:263-73 pubmed publisher
Sasahara M, Otani A, Oishi A, Kojima H, Yodoi Y, Kameda T, et al. Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration. Am J Pathol. 2008;172:1693-703 pubmed publisher
Lin Y, Xu L, Jin H, Zhong Y, Di J, Lin Q. CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice. Fertil Steril. 2009;91:2687-96 pubmed publisher
Wei Y, Tang Y, Li J, Cui C, Zhang H, Zhang X, et al. Cloning and expression pattern of dog SDF-1 and the implications of altered expression of SDF-1 in ischemic myocardium. Cytokine. 2007;40:52-9 pubmed
Petty J, Sueblinvong V, Lenox C, Jones C, Cosgrove G, Cool C, et al. Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury. J Immunol. 2007;178:8148-57 pubmed
Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, et al. Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood. 2007;109:3706-12 pubmed
Massberg S, Konrad I, Schürzinger K, Lorenz M, Schneider S, Zohlnhoefer D, et al. Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med. 2006;203:1221-33 pubmed
Butler J, Guthrie S, Koc M, Afzal A, Caballero S, Brooks H, et al. SDF-1 is both necessary and sufficient to promote proliferative retinopathy. J Clin Invest. 2005;115:86-93 pubmed
Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, et al. The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Blood. 2005;105:31-9 pubmed
Cardones A, Murakami T, Hwang S. CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin. Cancer Res. 2003;63:6751-7 pubmed
Villalba S, Salvucci O, Aoki Y, De La Luz Sierra M, Gupta G, Davis D, et al. Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo. J Leukoc Biol. 2003;74:880-8 pubmed
product information
brand :
R&D Systems
master code :
MAB310
SKU :
MAB310-100
product name :
Human/Mouse CXCL12/SDF-1 Antibody
description :
The Human/Mouse CXCL12/SDF-1 Antibody from R&D Systems is a mouse monoclonal antibody to CXCL12/SDF-1. This antibody reacts with human, mouse. The Human/Mouse CXCL12/SDF-1 Antibody has been validated for the following applications: Neutralization.
target :
CXCL12/SDF-1
category :
Primary Antibodies
unit size :
100 ug (also 25 ug, 500 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
79014
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant human CXCL12/SDF-1 alpha , Lys22-Lys89, Accession # Q6ICW0
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human, Mouse
specificity :
Detects human and mouse CXCL12/SDF-1 alpha and human CXCL12/SDF-1 beta .
gene symbol :
CXCL12
endotoxin note :
<0.10 EU per 1 µg of the antibody by the LAL method.
catalog number base :
MAB310
accessionNumbers :
Q6ICW0
applications :
Neutralization
2020 USD :
339
2021 USD :
369 USD
alt names :
chemokine (C-X-C motif) ligand 12, C-X-C motif chemokine 12, hIRH, hSDF-1, Intercrine reduced in hepatomas, IRH, PBSF, PBSFSDF-1a, Pre-B cell growth-stimulating factor, SCYB12, SDF1, SDF-1, SDF1A, SDF1B, SDF1SDF-1b, stromal cell-derived factor 1, TLSF, TLSF-a, TLSF-b, TPAR1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.