Human IL-7R alpha/CD127 Antibody | R&D Systems MAB306 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-7R alpha/CD127 Antibody

catalog :

MAB306

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

40131

reactivity :

human

application :

western blot, flow cytometry

citations: 11

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 5a	Li Y, Buijs Gladdines J, Cant Barrett K, Stubbs A, Vroegindeweij E, Smits W, et al. IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study. PLoS Med. 2016;13:e1002200 pubmed publisher
western blot; human; loading ...; fig 3b	Cant Barrett K, Spijkers Hagelstein J, Buijs Gladdines J, Uitdehaag J, Smits W, van der Zwet J, et al. MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia. Leukemia. 2016;30:1832-43 pubmed publisher
	Côté S, Burke Schinkel S, Berthoud T, Barros P, Sanchez Vidales M, Davidson A, et al. IL-7 induces sCD127 release and mCD127 downregulation in human CD8+ T cells by distinct yet overlapping mechanisms, both of which are impaired in HIV infection. Eur J Immunol. 2020;50:1537-1549 pubmed publisher
	Al Mossawi H, Yager N, Taylor C, Lau E, Danielli S, de Wit J, et al. Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele. Nat Commun. 2019;10:4575 pubmed publisher
	Judge C, Kostadinova L, Sherman K, Butt A, Falck Ytter Y, Funderburg N, et al. CD56bright NK IL-7Rα expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections. J Leukoc Biol. 2017;102:171-184 pubmed publisher
	Pedroza Pacheco I, Shah D, Domogala A, Luevano M, Blundell M, Jackson N, et al. Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation. Sci Rep. 2016;6:22097 pubmed publisher
	Wang S, Chen I, Liao Y, Liu C. The clinical correlation of regulatory T cells and cyclic adenosine monophosphate in enterovirus 71 infection. PLoS ONE. 2014;9:e102025 pubmed publisher
	Kreft K, Verbraak E, Wierenga Wolf A, Van Meurs M, Oostra B, Laman J, et al. Decreased systemic IL-7 and soluble IL-7R? in multiple sclerosis patients. Genes Immun. 2012;13:587-92 pubmed publisher
	Hoe E, McKay F, Schibeci S, Gandhi K, Heard R, Stewart G, et al. Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. J Immunol. 2010;184:2512-7 pubmed publisher
	Rose T, Lambotte O, Pallier C, Delfraissy J, Colle J. Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients. J Immunol. 2009;182:7389-97 pubmed publisher
	Srivastava B, Srivastava M. Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma. Leuk Res. 2005;29:771-83 pubmed

product information

brand :

R&D Systems

master code :

MAB306

SKU :

MAB306-100

product name :

Human IL-7R alpha/CD127 Antibody

description :

The Human IL-7R alpha/CD127 Antibody from R&D Systems is a mouse monoclonal antibody to IL-7R alpha/CD127. This antibody reacts with human. The Human IL-7R alpha/CD127 Antibody has been validated for the following applications: Western Blot, Flow Cytometry, CyTOF-ready.

target :

IL-7R alpha/CD127

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

40131

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human IL-7 R alpha , Extracellular domain

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human IL-7 R alpha in Western blots. In Western blots, approximately 5% cross-reactivity was observed with recombinant human (rh) IL-10 R, rhIL-2 R beta , rhIL-5 R alpha , and rhIL-6 R.

gene symbol :

IL7R

catalog number base :

MAB306

applications :

Western Blot, Flow Cytometry, CyTOF-ready

2020 USD :

339

2021 USD :

369 USD

alt names :

CD127, CD127 antigen, CD127ILRA, CDW127, IL-7 R alpha, IL-7 receptor subunit alpha, IL7R, IL7R alpha, IL-7R subunit alpha, IL7RA, IL-7RA, IL-7R-alpha, interleukin 7 receptor, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6, interleukin-7 receptor subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.