Human IL-7R alpha/CD127 Antibody | R&D Systems MAB306-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-7R alpha/CD127 Antibody

catalog :

MAB306-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

40131

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry

more info or order :

R&D Systems product webpage

citations: 17

Reference
Sigal N, Maecker H. Mass Cytometry Assessment of Cell Phenotypes and Signaling States in Human Whole Blood. Methods Mol Biol. 2022;2543:113-128 pubmed publisher
Galarza Mu xf1 oz G, Kennedy Boone D, Schott G, Bradrick S, Garcia Blanco M. Antisense modulation of IL7R splicing to control sIL7R expression in human CD4+ T cells. RNA. 2022;28:1058-1073 pubmed publisher
Hehenkamp P, Hoffmann M, Kummer S, Reinauer C, D xf6 ing C, F xf6 rtsch K, et al. Interleukin-7-dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetes. Eur J Immunol. 2021;51:3214-3227 pubmed publisher
Rueschenbaum S, Cai C, Schmidt M, Schwarzkopf K, Dittmer U, Zeuzem S, et al. Translation of IRF-1 Restricts Hepatic Interleukin-7 Production to Types I and II Interferons: Implications for Hepatic Immunity. Front Immunol. 2020;11:581352 pubmed publisher
Abdelrasoul H, Vadakumchery A, Werner M, Lenk L, Khadour A, Young M, et al. Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Nat Commun. 2020;11:3194 pubmed publisher
Côté S, Burke Schinkel S, Berthoud T, Barros P, Sanchez Vidales M, Davidson A, et al. IL-7 induces sCD127 release and mCD127 downregulation in human CD8+ T cells by distinct yet overlapping mechanisms, both of which are impaired in HIV infection. Eur J Immunol. 2020;50:1537-1549 pubmed publisher
Al Mossawi H, Yager N, Taylor C, Lau E, Danielli S, de Wit J, et al. Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele. Nat Commun. 2019;10:4575 pubmed publisher
Kim S, Chang H, Volin M, Umar S, Van Raemdonck K, Chevalier A, et al. Macrophages are the primary effector cells in IL-7-induced arthritis. Cell Mol Immunol. 2019;: pubmed publisher
Judge C, Kostadinova L, Sherman K, Butt A, Falck Ytter Y, Funderburg N, et al. CD56bright NK IL-7Rα expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections. J Leukoc Biol. 2017;102:171-184 pubmed publisher
Li Y, Buijs Gladdines J, Cant Barrett K, Stubbs A, Vroegindeweij E, Smits W, et al. IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study. PLoS Med. 2016;13:e1002200 pubmed publisher
Cant Barrett K, Spijkers Hagelstein J, Buijs Gladdines J, Uitdehaag J, Smits W, van der Zwet J, et al. MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia. Leukemia. 2016;30:1832-43 pubmed publisher
Pedroza Pacheco I, Shah D, Domogala A, Luevano M, Blundell M, Jackson N, et al. Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation. Sci Rep. 2016;6:22097 pubmed publisher
Wang S, Chen I, Liao Y, Liu C. The clinical correlation of regulatory T cells and cyclic adenosine monophosphate in enterovirus 71 infection. PLoS ONE. 2014;9:e102025 pubmed publisher
Kreft K, Verbraak E, Wierenga Wolf A, Van Meurs M, Oostra B, Laman J, et al. Decreased systemic IL-7 and soluble IL-7R? in multiple sclerosis patients. Genes Immun. 2012;13:587-92 pubmed publisher
Hoe E, McKay F, Schibeci S, Gandhi K, Heard R, Stewart G, et al. Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. J Immunol. 2010;184:2512-7 pubmed publisher
Rose T, Lambotte O, Pallier C, Delfraissy J, Colle J. Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients. J Immunol. 2009;182:7389-97 pubmed publisher
Srivastava B, Srivastava M. Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma. Leuk Res. 2005;29:771-83 pubmed

product information

brand :

R&D Systems

master code :

MAB306

SKU :

MAB306-100

product name :

Human IL-7R alpha/CD127 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human IL-7R alpha/CD127 Antibody from R&D Systems is a mouse monoclonal antibody to IL-7R alpha/CD127. This antibody reacts with human,mouse. The Human IL-7R alpha/CD127 Antibody has been validated for the following applications: Mass Cytometry,ELISA Development,Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,ELISA Capture,Immunocytochemistry,CyTOF-ready.

target :

IL-7R alpha/CD127

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

40131

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Flow Cytometry 2.5 ug/10^6 cells, CyTOF-ready

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human IL-7 R alpha , Extracellular domain

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human,Mouse

specificity :

Detects human IL-7 R alpha in Western blots. In Western blots, approximately 5% cross-reactivity was observed with recombinant human (rh) IL-10 R, rhIL-2 R▀, rhIL-5 R alpha , and rhIL-6 R.

gene symbol :

IL7R

top caption :

Detection of IL-7 Ra/CD127 antibody in Human Blood Lymphocytes antibody by Flow Cytometry.

applications :

CyTOF-ready,ELISA Development,Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,Immunocytochemistry,ELISA Capture

USD :

499 USD

alt names :

CD127, CD127 antigen, CD127ILRA, CDW127, IL-7 R alpha, IL-7 receptor subunit alpha, IL7R, IL7R alpha, IL-7R subunit alpha, IL7RA, IL-7RA, IL-7R-alpha, interleukin 7 receptor, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6, interleukin-7 receptor subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage