Human Integrin alpha V▀3 Antibody | R&D Systems MAB3050 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Integrin alpha V▀3 Antibody

catalog :

MAB3050

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

23C6

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 21

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig s2	Jung K, Son M, Lee S, Kim J, Ko D, Yoo S, et al. Antibody-mediated delivery of a viral MHC-I epitope into the cytosol of target tumor cells repurposes virus-specific CD8+ T cells for cancer immunotherapy. Mol Cancer. 2022;21:102 pubmed publisher
	Gay L, Suwan K, Hajitou A. Construction and utilization of a new generation of bacteriophage-based particles, or TPA, for guided systemic delivery of nucleic acids to tumors. Nat Protoc. 2024;: pubmed publisher
	Lawaetz M, Christensen A, Juhl K, Karnov K, Lelkaitis G, Kanstrup Fiehn A, et al. Potential of uPAR, αvβ6 Integrin, and Tissue Factor as Targets for Molecular Imaging of Oral Squamous Cell Carcinoma: Evaluation of Nine Targets in Primary Tumors and Metastases by Immunohistochemistry. Int J Mol Sci. 2023;24: pubmed publisher
	Gringhuis S, Kaptein T, Remmerswaal E, Drewniak A, Wevers B, Theelen B, et al. Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs. Nat Immunol. 2022;23:1735-1748 pubmed publisher
	Shin S, Kim J, Park S, Jun S, Kweon H, Choi D, et al. Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant-driven tumor growth. Sci Adv. 2020;6:eaay2174 pubmed publisher
	Peterman E, Gibieža P, Schafer J, Skeberdis V, Kaupinis A, Valius M, et al. The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation. Nat Commun. 2019;10:3181 pubmed publisher
	Mena H, Zubiry P, Dizier B, Schattner M, Boisson Vidal C, Negrotto S. Acidic preconditioning of endothelial colony-forming cells (ECFC) promote vasculogenesis under proinflammatory and high glucose conditions in vitro and in vivo. Stem Cell Res Ther. 2018;9:120 pubmed publisher
	Jin Y, Valenzuela N, Zhang X, Rozengurt E, Reed E. HLA Class II-Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection. J Immunol. 2018;200:2372-2390 pubmed publisher
	Fan C, Chen W, Chen L, Chen C, Hsu Y, Chua K, et al. Osteopontin-integrin engagement induces HIF-1Î±-TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer. Oncotarget. 2018;9:4998-5015 pubmed publisher
	Elnaggar A, Farag A, Gaber M, Hafeez M, Ali M, Atef A. AlphaVBeta3 Integrin expression within uterine endometrium in unexplained infertility: a prospective cohort study. BMC Womens Health. 2017;17:90 pubmed publisher
	Gillespie S, Tedesco L, Wang L, Bernstein A. The deubiquitylase USP10 regulates integrin β1 and β5 and fibrotic wound healing. J Cell Sci. 2017;130:3481-3495 pubmed publisher
	Miyano K, Cabral H, Miura Y, Matsumoto Y, Mochida Y, Kinoh H, et al. cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. J Control Release. 2017;261:275-286 pubmed publisher
	Park S, Piao Y, Jeong K, Dong J, de Groot J. Periostin (POSTN) Regulates Tumor Resistance to Antiangiogenic Therapy in Glioma Models. Mol Cancer Ther. 2016;15:2187-97 pubmed publisher
	Ma V, Liu Y, Yehl K, Galior K, Zhang Y, Salaita K. Mechanically Induced Catalytic Amplification Reaction for Readout of Receptor-Mediated Cellular Forces. Angew Chem Int Ed Engl. 2016;55:5488-92 pubmed publisher
	Su C, Chiang Y, Huang C, Hsu C, Fong Y, Tang C. Osteopontin Promotes Oncostatin M Production in Human Osteoblasts: Implication of Rheumatoid Arthritis Therapy. J Immunol. 2015;195:3355-64 pubmed publisher
	Kasonga A, Deepak V, Kruger M, Coetzee M. Arachidonic acid and docosahexaenoic acid suppress osteoclast formation and activity in human CD14+ monocytes, in vitro. PLoS ONE. 2015;10:e0125145 pubmed publisher
	Zhang P, Fu C, Hu Y, Dong C, Song Y, Song E. C6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCÎ¶ tumor-suppressive activities and regulating integrin affinity modulation. Sci Rep. 2015;5:9275 pubmed publisher
	Dotterweich J, Ebert R, Kraus S, Tower R, Jakob F, Schutze N. Mesenchymal stem cell contact promotes CCN1 splicing and transcription in myeloma cells. Cell Commun Signal. 2014;12:36 pubmed publisher
	Deniro M, Al Mohanna F, Alsmadi O, Al Mohanna F. The nexus between VEGF and NF?B orchestrates a hypoxia-independent neovasculogenesis. PLoS ONE. 2013;8:e59021 pubmed publisher
	Kibria G, Hatakeyama H, Ohga N, Hida K, Harashima H. Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery. J Control Release. 2011;153:141-8 pubmed publisher
	Suri S, Rakotondradany F, Myles A, Fenniri H, Singh B. The role of RGD-tagged helical rosette nanotubes in the induction of inflammation and apoptosis in human lung adenocarcinoma cells through the P38 MAPK pathway. Biomaterials. 2009;30:3084-90 pubmed publisher

product information

brand :

R&D Systems

master code :

MAB3050

SKU :

MAB3050

product name :

Human Integrin alpha V▀3 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human Integrin alpha Vß3 Antibody from R&D Systems is a mouse monoclonal antibody to Integrin alpha V beta 3. This antibody reacts with human. The Human Integrin alpha Vß3 Antibody has been validated for the following applications: Flow Cytometry,Bioassay,Western Blot,Neutralization,Functional Assay,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,Immunoprecipitation,Adhesion Blockade,CyTOF-ready.

target :

Integrin alpha V beta 3

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

23C6

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Flow Cytometry 2.5 ug/10^6 cells, Immunohistochemistry 8-25 ug/mL, Immunoprecipitation, Adhesion Blockade, CyTOF-ready

host :

Mouse

immunogen :

Human osteoclasts

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human Integrin alpha V▀3.

gene symbol :

ITGAV

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Human Integrin alpha V beta 3 by Immunocytochemistry/Immunofluorescence

applications :

Immunoprecipitation,Adhesion Blockade,CyTOF-ready,Bioassay,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry,Functional Assay

USD :

499 USD

alt names :

antigen identified by monoclonal L230, CD51, CD51 antigen, CD61, GP3A, GPIIIA, INGRB3, integrin alpha-V, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), ITGAV, ITGB3, MSK8, Vitronectin Receptor alpha, Vitronectin receptor subunit alpha, VNRA, VNRADKFZp686A08142

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage