Human IGFBP-3 Antibody | R&D Systems MAB305 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IGFBP-3 Antibody

catalog :

MAB305

quantity :

100 ug (also 25 ug, 500 ug)

price :

359 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

84728

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

citations: 6

Reference
Wang F, Liu H, Hu L, Liu Y, Duan Y, Cui R, et al. The Warburg effect in human pancreatic cancer cells triggers cachexia in athymic mice carrying the cancer cells. BMC Cancer. 2018;18:360 pubmed publisher
Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, et al. The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. Mol Brain. 2015;8:82 pubmed publisher
Natsuizaka M, Kinugasa H, Kagawa S, Whelan K, Naganuma S, Subramanian H, et al. IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment. Am J Cancer Res. 2014;4:29-41 pubmed
Elzi D, Lai Y, Song M, Hakala K, Weintraub S, Shiio Y. Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence. Proc Natl Acad Sci U S A. 2012;109:12052-7 pubmed publisher
Nguyen K, Yao X, Moulik S, Mishra S, Nyomba B. Human IGF binding protein-3 overexpression impairs glucose regulation in mice via an inhibition of insulin secretion. Endocrinology. 2011;152:2184-96 pubmed publisher
Takaoka M, Harada H, Andl C, Oyama K, Naomoto Y, Dempsey K, et al. Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3. Cancer Res. 2004;64:7711-23 pubmed

product information

brand :

R&D Systems

master code :

MAB305

SKU :

MAB305-100

product name :

Human IGFBP-3 Antibody

description :

The Human IGFBP-3 Antibody from R&D Systems is a mouse monoclonal antibody to IGFBP-3. This antibody reacts with human. The Human IGFBP-3 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, ELISA Capture (Matched Antibody Pair).

target :

IGFBP-3

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

84728

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human IGFBP-3, Gly28-Lys291, Accession # CAA46087

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IGFBP-3 in ELISAs and Western blots. In sandwich immunoassays, less than 0.25% cross-reactivity with recombinant human (rh) IGF-I R, rhIGFBP-1, rhIGFBP-2, rhIGFBP-4, rhIGFBP-5, and rhIGFBP-6 is observed.

gene symbol :

IGFBP3

catalog number base :

MAB305

accessionNumbers :

CAA46087

applications :

Western Blot, Immunohistochemistry, ELISA Capture (Matched Antibody Pair)

2020 USD :

339

2021 USD :

359 USD

alt names :

acid stable subunit of the 140 K IGF complex, binding protein 29, binding protein 53, growth hormone-dependent binding protein, IBP-3, IBP3BP-53, IGF-binding protein 3, IGFBP3, IGFBP-3, insulin-like growth factor binding protein 3, insulin-like growth factor-binding protein 3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.