Human IGFBP-3 Antibody | R&D Systems MAB305-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IGFBP-3 Antibody

catalog :

MAB305-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

84728

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 13

Reference
Chen Y, Tien S, Ko Y, Chang C, Hsu M, Chien H, et al. SEMA7A-mediated juxtacrine stimulation of IGFBP-3 upregulates IL-17RB at pancreatic cancer invasive front. Cancer Gene Ther. 2024;31:1840-1855 pubmed publisher
Hasuike Y, Mochizuki H, Nakamori M. Expanded CUG Repeat RNA Induces Premature Senescence in Myotonic Dystrophy Model Cells. Front Genet. 2022;13:865811 pubmed publisher
Shih H, Chang H, Chen C, Torng P. Differential expression of hypoxia-inducible factors related to the invasiveness of epithelial ovarian cancer. Sci Rep. 2021;11:22925 pubmed publisher
Sakata J, Hirosue A, Yoshida R, Matsuoka Y, Kawahara K, Arita H, et al. Enhanced Expression of IGFBP-3 Reduces Radiosensitivity and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma. Cancers (Basel). 2020;12: pubmed publisher
Titone R, Zhu M, Robertson D. Mutual regulation between IGF-1R and IGFBP-3 in human corneal epithelial cells. J Cell Physiol. 2019;234:1426-1441 pubmed publisher
Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, et al. The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. Mol Brain. 2015;8:82 pubmed publisher
Yen Y, Hsiao J, Jiang S, Chang J, Wang S, Shen Y, et al. Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1. Oncotarget. 2015;6:41837-55 pubmed publisher
Natsuizaka M, Kinugasa H, Kagawa S, Whelan K, Naganuma S, Subramanian H, et al. IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment. Am J Cancer Res. 2014;4:29-41 pubmed
Seligson D, Yu H, Tze S, Said J, Pantuck A, Cohen P, et al. IGFBP-3 nuclear localization predicts human prostate cancer recurrence. Horm Cancer. 2013;4:12-23 pubmed publisher
Elzi D, Lai Y, Song M, Hakala K, Weintraub S, Shiio Y. Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence. Proc Natl Acad Sci U S A. 2012;109:12052-7 pubmed publisher
Tuan T, Chung C, Tsou H, Chen F, Lin H, Lai Y, et al. Putative tumor metastasis-associated genes in human gastric cancer. Int J Oncol. 2012;41:1068-84 pubmed publisher
Nguyen K, Yao X, Moulik S, Mishra S, Nyomba B. Human IGF binding protein-3 overexpression impairs glucose regulation in mice via an inhibition of insulin secretion. Endocrinology. 2011;152:2184-96 pubmed publisher
Takaoka M, Harada H, Andl C, Oyama K, Naomoto Y, Dempsey K, et al. Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3. Cancer Res. 2004;64:7711-23 pubmed

product information

master code :

MAB305

SKU :

MAB305-100

product name :

Human IGFBP-3 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human IGFBP-3 Antibody from R&D Systems is a mouse monoclonal antibody to IGFBP-3. This antibody reacts with human,mouse,xenograft. The Human IGFBP-3 Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunocytochemistry,Neutralization,Immunohistochemistry-Paraffin,ELISA Capture (Matched Antibody Pair).

target :

IGFBP-3

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

84728

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human IGFBP-3, Gly28-Lys291, Accession # CAA46087

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Xenograft

specificity :

Detects human IGFBP-3 in ELISAs and Western blots. In sandwich immunoassays, less than 0.25% cross-reactivity with recombinant human (rh) IGF-I R, rhIGFBP-1, rhIGFBP-2, rhIGFBP-4, rhIGFBP-5, and rhIGFBP-6 is observed.

gene symbol :

IGFBP3

top caption :

IGFBP-3 antibody in Human Placenta by Immunohistochemistry (IHC-P).

accessionNumbers :

CAA46087

applications :

Immunohistochemistry,Immunocytochemistry,Western Blot,Neutralization,Immunohistochemistry-Paraffin,ELISA Capture (Matched Antibody Pair)

USD :

459 USD

alt names :

acid stable subunit of the 140 K IGF complex, binding protein 29, binding protein 53, growth hormone-dependent binding protein, IBP-3, IBP3BP-53, IGF-binding protein 3, IGFBP3, IGFBP-3, insulin-like growth factor binding protein 3, insulin-like growth factor-binding protein 3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage