Human VEGF165b Antibody | R&D Systems MAB3045-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human VEGF165b Antibody

catalog :

MAB3045-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

56-1

reactivity :

human, mouse, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 23

Reference
Quan B, Li Z, Yang H, Li S, Yan X, Wang Y. The splicing factor YBX1 promotes the progression of osteosarcoma by upregulating VEGF165 and downregulating VEGF165b. Heliyon. 2023;9:e18706 pubmed publisher
Jia T, Jacquet T, Dalonneau F, Coudert P, Vaganay E, Exbrayat Héritier C, et al. FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells. BMC Biol. 2021;19:173 pubmed publisher
Prodjohardjono A, Vidyanti A, Susianti N, Sudarmanta -, Sutarni S, Setyopranoto I. Higher level of acute serum VEGF and larger infarct volume are more frequently associated with post-stroke cognitive impairment. PLoS ONE. 2020;15:e0239370 pubmed publisher
Hawke L, Whitford M, Ormiston M. The Production of Pro-angiogenic VEGF-A Isoforms by Hypoxic Human NK Cells Is Independent of Their TGF-β-Mediated Conversion to an ILC1-Like Phenotype. Front Immunol. 2020;11:1903 pubmed publisher
Stassi A, Gasser F, Velázquez M, Belotti E, Gareis N, Rey F, et al. Contribution of the VEGF system to the follicular persistence associated with bovine cystic ovaries. Theriogenology. 2019;138:52-65 pubmed publisher
Biselli Chicote P, Biselli J, Cunha B, Castro R, Maniglia J, Neto D, et al. Overexpression of Antiangiogenic Vascular Endothelial Growth Factor Isoform and Splicing Regulatory Factors in Oral, Laryngeal and Pharyngeal Squamous Cell Carcinomas. Asian Pac J Cancer Prev. 2017;18:2171-2177 pubmed
Karki S, Ngo D, Farb M, Park S, Saggese S, Hamburg N, et al. WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A165b in obese humans. Am J Physiol Heart Circ Physiol. 2017;313:H200-H206 pubmed publisher
Nagasaki M, Kondo S, Mukudai Y, Kamatani T, Akizuki A, Yaso A, et al. Clinicopathological implications of vascular endothelial growth factor 165b expression in oral squamous cell carcinoma stroma. Oncol Rep. 2016;36:573-81 pubmed publisher
Kim H, Kim K, Kim B, Cho M, Lee S. The effect of vascular endothelial growth factor on osteoclastogenesis in rheumatoid arthritis. PLoS ONE. 2015;10:e0124909 pubmed publisher
Carter J, Gammons M, Damodaran G, Churchill A, Harper S, Bates D. The carboxyl terminus of VEGF-A is a potential target for anti-angiogenic therapy. Angiogenesis. 2015;18:23-30 pubmed publisher
Bills V, Hamdollah Zadeh M, Soothill P, Harper S, Bates D. The role of VEGF-A165b in trophoblast survival. BMC Pregnancy Childbirth. 2014;14:278 pubmed publisher
Ngo D, Farb M, Kikuchi R, Karki S, Tiwari S, Bigornia S, et al. Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity. Circulation. 2014;130:1072-80 pubmed publisher
Van t Hull E, Bron S, Henry L, Ifticene Treboux A, Turrini R, Coukos G, et al. Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer. Oncoimmunology. 2014;3:e29080 pubmed
Bates D, Mavrou A, Qiu Y, Carter J, Hamdollah Zadeh M, Barratt S, et al. Detection of VEGF-A(xxx)b isoforms in human tissues. PLoS ONE. 2013;8:e68399 pubmed publisher
Gupta P, Adkins C, Lockman P, Srivastava S. Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis Model. PLoS ONE. 2013;8:e67278 pubmed publisher
Woolard J, Vousden W, Moss S, Krishnakumar A, Gammons M, Nowak D, et al. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chem Sci. 2011;2011:273-278 pubmed
Makarevich P, Tsokolaeva Z, Shevelev A, Rybalkin I, Shevchenko E, Beloglazova I, et al. Combined transfer of human VEGF165 and HGF genes renders potent angiogenic effect in ischemic skeletal muscle. PLoS ONE. 2012;7:e38776 pubmed publisher
Merdzhanova G, Gout S, Keramidas M, Edmond V, Coll J, Brambilla C, et al. The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo. Oncogene. 2010;29:5392-403 pubmed publisher
Hua J, Spee C, Kase S, Rennel E, Magnussen A, Qiu Y, et al. Recombinant human VEGF165b inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010;51:4282-8 pubmed publisher
Magnussen A, Rennel E, Hua J, Bevan H, Beazley Long N, Lehrling C, et al. VEGF-A165b is cytoprotective and antiangiogenic in the retina. Invest Ophthalmol Vis Sci. 2010;51:4273-81 pubmed publisher
Varet J, Douglas S, Gilmartin L, Medford A, Bates D, Harper S, et al. VEGF in the lung: a role for novel isoforms. Am J Physiol Lung Cell Mol Physiol. 2010;298:L768-74 pubmed publisher
Rennel E, Varey A, Churchill A, Wheatley E, Stewart L, Mather S, et al. VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo. Br J Cancer. 2009;101:1183-93 pubmed publisher
Bates D, MacMillan P, Manjaly J, Qiu Y, Hudson S, Bevan H, et al. The endogenous anti-angiogenic family of splice variants of VEGF, VEGFxxxb, are down-regulated in pre-eclamptic placentae at term. Clin Sci (Lond). 2006;110:575-85 pubmed

product information

brand :

R&D Systems

master code :

MAB3045

SKU :

MAB3045-100

product name :

Human VEGF165b Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human VEGF165b Antibody from R&D Systems is a mouse monoclonal antibody to VEGF. This antibody reacts with bovine,human,mouse. The Human VEGF165b Antibody has been validated for the following applications: ELISA Development,Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunofluorescence.

target :

VEGF

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

56-1

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Immunohistochemistry 8-25 ug/mL, Immunofluorescence

host :

Mouse

immunogen :

KLH-conjugated human VEGF165b synthetic peptide, TCRSLTRKD, Accession # AAL27435

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Bovine,Human,Mouse

specificity :

Detects human VEGF165b in direct ELISAs and Western blots. Recognizes an epitope within a 9 amino acid sequence at the C-terminus of human VEGF165b. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) VEGF206, rhVEGF-B167, rhVEGF-B186, rhVEGF-C, or rhVEGF-D is observed.

gene symbol :

VEGFA

top caption :

VEGF165bin Human Placenta by Immunohistochemistry (IHC-P).

accessionNumbers :

AAL27435

applications :

Immunofluorescence,ELISA Development,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization

USD :

479 USD

alt names :

MVCD1, VAS, vascular endothelial growth factor A, Vascular permeability factor, Vasculotropin, VEGFA, VEGF-A, VEGFMGC70609, VPF, VPFvascular endothelial growth factor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage