product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human IL-3R alpha/CD123 Antibody
catalog :
MAB301-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
32703
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 10
Reference
Koni M, Castellano I, Venturelli E, Sarcinella A, Lopatina T, Grange C, et al. Interleukin-3-Receptor-α in Triple-Negative Breast Cancer (TNBC): An Additional Novel Biomarker of TNBC Aggressiveness and a Therapeutic Target. Cancers (Basel). 2022;14: pubmed publisher
Lopatina T, Grange C, Cavallari C, Navarro Tableros V, Lombardo G, Rosso A, et al. Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming. Oncogenesis. 2020;9:90 pubmed publisher
Chen J, Kao Y, Sun D, Todorova T, Reynolds D, Narayanagari S, et al. Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level. Nat Med. 2019;25:103-110 pubmed publisher
Broughton S, Hercus T, Nero T, Kan W, Barry E, Dottore M, et al. A dual role for the N-terminal domain of the IL-3 receptor in cell signalling. Nat Commun. 2018;9:386 pubmed publisher
Barhanpurkar Naik A, Mhaske S, Pote S, Singh K, Wani M. Interleukin-3 enhances the migration of human mesenchymal stem cells by regulating expression of CXCR4. Stem Cell Res Ther. 2017;8:168 pubmed publisher
Dijkstra D, Meyer Bahlburg A. Human Basophils Modulate Plasma Cell Differentiation and Maturation. J Immunol. 2017;198:229-238 pubmed
Lombardo G, Dentelli P, Togliatto G, Rosso A, Gili M, Gallo S, et al. Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action. Sci Rep. 2016;6:25689 pubmed publisher
Gschweitl M, Ulbricht A, Barnes C, Enchev R, Stoffel Studer I, Meyer Schaller N, et al. A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes. elife. 2016;5:e13841 pubmed publisher
Leskela S, Serrano A, de la Fuente H, Rodríguez Muñoz A, Ramos Levi A, Sampedro Nuñez M, et al. Graves' disease is associated with a defective expression of the immune regulatory molecule galectin-9 in antigen-presenting dendritic cells. PLoS ONE. 2015;10:e0123938 pubmed publisher
Bovolenta C, Pilotti E, Mauri M, Turci M, Ciancianaini P, Fisicaro P, et al. Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor. Blood. 2002;99:224-31 pubmed
product information
master code :
MAB301
SKU :
MAB301-100
product name :
Human IL-3R alpha/CD123 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human IL-3R alpha/CD123 Antibody from R&D Systems is a mouse monoclonal antibody to IL-3R alpha/CD123. This antibody reacts with human. The Human IL-3R alpha/CD123 Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry-Frozen,Immunohistochemistry,Immunocytochemistry,CyTOF-ready.
target :
IL-3R alpha
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
32703
conjugate :
Unconjugated
host :
Mouse
immunogen :
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-3 R alpha /CD123, Lys20-Arg305, predicted, Accession # P26951
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human IL-3 R alpha /CD123 in direct ELISAs and Western blots.
gene symbol :
IL3RA
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
IL-3 Ra/CD123 antibody in Human Peripheral Blood Lymphocytes by Immunocytochemistry (ICC).
accessionNumbers :
P26951
applications :
Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry-Frozen,Immunohistochemistry,Immunocytochemistry,CyTOF-ready
USD :
469 USD
alt names :
CD123, CD123 antigen, hIL3Ra, hIL-3Ra, IL-3 R alpha, IL-3 receptor subunit alpha, IL3R, IL3R alpha, IL-3R subunit alpha, IL3RA, IL-3RA, IL-3R-alpha, IL3RAY, IL3RX, IL3RY, interleukin 3 receptor, alpha (low affinity), interleukin-3 receptor subunit alpha, MGC34174
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.