product summary
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company name :
R&D Systems
product type :
antibody
product name :
Oncostatin M/OSM Antibody
catalog :
MAB295-100
quantity :
100 ug (also 500 ug, 25 ug)
price :
459 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
17001
reactivity :
human
application :
western blot, ELISA, neutralization
more info or order :
R&D Systems product webpage
citations: 8
Reference
Jones M, Vanyo S, Ibraheem W, Maddi A, Visser M. Treponema denticola stimulates Oncostatin M cytokine release and de novo synthesis in neutrophils and macrophages. J Leukoc Biol. 2020;108:1527-1541 pubmed publisher
Rolvering C, Zimmer A, Ginolhac A, Margue C, Kirchmeyer M, Servais F, et al. The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies. J Leukoc Biol. 2018;104:969-985 pubmed publisher
Torossian F, Guerton B, Anginot A, Alexander K, Desterke C, Soave S, et al. Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight. 2017;2: pubmed publisher
Su C, Chiang Y, Huang C, Hsu C, Fong Y, Tang C. Osteopontin Promotes Oncostatin M Production in Human Osteoblasts: Implication of Rheumatoid Arthritis Therapy. J Immunol. 2015;195:3355-64 pubmed publisher
Nicolaidou V, Wong M, Redpath A, Ersek A, Baban D, Williams L, et al. Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation. PLoS ONE. 2012;7:e39871 pubmed publisher
Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C. Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis. J Biol Chem. 2011;286:34271-85 pubmed publisher
Duluc D, Delneste Y, Tan F, Moles M, Grimaud L, Lenoir J, et al. Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood. 2007;110:4319-30 pubmed
Hurst S, McLoughlin R, Monslow J, Owens S, Morgan L, Fuller G, et al. Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J Immunol. 2002;169:5244-51 pubmed
image
image 1 :
R&D Systems MAB295-100 image 1
Cell Proliferation Induced by Oncostatin M/OSM and Neutralization by Human Oncostatin M/OSM Antibody.
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
MAB295
SKU :
MAB295-100
product name :
Oncostatin M/OSM Antibody
Description :
The Human Oncostatin M/OSM Antibody from R&D Systems is a mouse monoclonal antibody to Oncostatin M/OSM. This antibody reacts with human. The Human Oncostatin M/OSM Antibody has been validated for the following applications: Western Blot, Neutralization, ELISA Capture (Matched Antibody Pair).
target :
Oncostatin M/OSM
category :
Primary Antibodies
unit size :
100 ug (also 500 ug, 25 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
17001
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant human Oncostatin M/OSM, Ala26-Arg234, Accession # P13725
isotype :
IgG2a
purity :
Protein A or G purified from ascites
species :
Human
specificity :
Detects human Oncostatin M in ELISAs and Western blots. In ELISAs, this antibody does not cross-react with recombinant human (rh) IL-6, rhIL-11, rhCNTF, or rhLIF.
gene symbol :
OSM
endotoxin note :
<0.10 EU per 1 µg of the antibody by the LAL method.
accessionNumbers :
P13725
applications :
Western Blot, Neutralization, ELISA Capture (Matched Antibody Pair)
USD :
459 USD
alt names :
MGC20461, oncostatin M, oncostatin-M
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.