Human HGF Antibody | R&D Systems MAB294-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human HGF Antibody

catalog :

MAB294-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

24612

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 32

Reference
Deng Y, Zhao Z, Sheldon M, Zhao Y, Teng H, Martínez C, et al. LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration. bioRxiv. 2023;: pubmed publisher
Kano F, Hashimoto N, Liu Y, Xia L, Nishihara T, Oki W, et al. Therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for radiation-induced mouse xerostomia. Sci Rep. 2023;13:2706 pubmed publisher
Jang H, Son Y, Park G, Park K. Bone Marrow-Derived Vasculogenic Mesenchymal Stem Cells Enhance In Vitro Angiogenic Sprouting of Human Umbilical Vein Endothelial Cells. Int J Mol Sci. 2022;24: pubmed publisher
Uruski P, Miku x142 a Pietrasik J, Paku x142 a M, Budkiewicz S, Drzewiecki M, Gaiday A, et al. Malignant Ascites Promote Adhesion of Ovarian Cancer Cells to Peritoneal Mesothelium and Fibroblasts. Int J Mol Sci. 2021;22: pubmed publisher
Chen B, Cai T, Huang C, Zang X, Sun L, Guo S, et al. G6PD-NF-κB-HGF Signal in Gastric Cancer-Associated Mesenchymal Stem Cells Promotes the Proliferation and Metastasis of Gastric Cancer Cells by Upregulating the Expression of HK2. Front Oncol. 2021;11:648706 pubmed publisher
Rudkouskaya A, Smith J, Intes X, Barroso M. Quantification of Trastuzumab-HER2 Engagement In Vitro and In Vivo. Molecules. 2020;25: pubmed publisher
Pakuła M, Mały E, Uruski P, Witucka A, Bogucka M, Jaroszewska N, et al. Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells. Cancers (Basel). 2020;12: pubmed publisher
Pakuła M, Uruski P, Niklas A, Wozniak A, Szpurek D, Tykarski A, et al. A Unique Pattern of Mesothelial-Mesenchymal Transition Induced in the Normal Peritoneal Mesothelium by High-Grade Serous Ovarian Cancer. Cancers (Basel). 2019;11: pubmed publisher
Lavine J, Ramos M, Wolk A, Baynes K, Sharma S, Rachitskaya A, et al. Heterogeneity of cultured melanocyte elongation and proliferation factor in bilateral diffuse uveal melanocytic proliferation. Exp Eye Res. 2019;184:30-37 pubmed publisher
Pakuła M, Mikuła Pietrasik J, Witucka A, Kostka Jeziorny K, Uruski P, Moszyński R, et al. The Epithelial-Mesenchymal Transition Initiated by Malignant Ascites Underlies the Transmesothelial Invasion of Ovarian Cancer Cells. Int J Mol Sci. 2019;20: pubmed publisher
Rao L, De Veirman K, Giannico D, Saltarella I, Desantis V, Frassanito M, et al. Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin® protein MP0250: a preclinical study. Oncotarget. 2018;9:13366-13381 pubmed publisher
Tomida C, Yamagishi N, Nagano H, Uchida T, Ohno A, Hirasaka K, et al. VEGF pathway-targeting drugs induce evasive adaptation by activation of neuropilin-1/cMet in colon cancer cells. Int J Oncol. 2018;52:1350-1362 pubmed publisher
Tjomsland V, Aasrum M, Christoffersen T, Gladhaug I. Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and migration in pancreatic cancer cells. Oncotarget. 2017;8:71672-71684 pubmed publisher
Qin Y, Roszik J, Chattopadhyay C, Hashimoto Y, Liu C, Cooper Z, et al. Hypoxia-Driven Mechanism of Vemurafenib Resistance in Melanoma. Mol Cancer Ther. 2016;15:2442-2454 pubmed
Rudisch A, Dewhurst M, Horga L, Kramer N, Harrer N, Dong M, et al. High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFÎºB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts. PLoS ONE. 2015;10:e0124283 pubmed publisher
Angelucci C, Maulucci G, Colabianchi A, Iacopino F, D Alessio A, Maiorana A, et al. Stearoyl-CoA desaturase 1 and paracrine diffusible signals have a major role in the promotion of breast cancer cell migration induced by cancer-associated fibroblasts. Br J Cancer. 2015;112:1675-86 pubmed publisher
Przybylski G, Chorostowska Wynimko J, Dyczek A, Wędrowska E, Jankowski M, Szpechcinski A, et al. Studies of hepatocyte growth factor in bronchoalveolar lavage fluid in chronic interstitial lung diseases. Pol Arch Med Wewn. 2015;125:260-71 pubmed
Aenlle K, Curtis K, Roos B, Howard G. Hepatocyte growth factor and p38 promote osteogenic differentiation of human mesenchymal stem cells. Mol Endocrinol. 2014;28:722-30 pubmed publisher
Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, et al. CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell. 2014;14:342-56 pubmed publisher
Wong J, Warbrick E, Vojtesk B, Hill J, Lane D. Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth. Oncotarget. 2013;4:1019-36 pubmed
Straussman R, Morikawa T, Shee K, Barzily Rokni M, Qian Z, Du J, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature. 2012;487:500-4 pubmed publisher
Makarevich P, Tsokolaeva Z, Shevelev A, Rybalkin I, Shevchenko E, Beloglazova I, et al. Combined transfer of human VEGF165 and HGF genes renders potent angiogenic effect in ischemic skeletal muscle. PLoS ONE. 2012;7:e38776 pubmed publisher
Sigurdsson V, Hilmarsdottir B, Sigmundsdottir H, Fridriksdottir A, Ringner M, Villadsen R, et al. Endothelial induced EMT in breast epithelial cells with stem cell properties. PLoS ONE. 2011;6:e23833 pubmed publisher
Tyan S, Kuo W, Huang C, Pan C, Shew J, Chang K, et al. Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis. PLoS ONE. 2011;6:e15313 pubmed publisher
Schipper H, de Jager W, van Dijk M, Meerding J, Zelissen P, Adan R, et al. A multiplex immunoassay for human adipokine profiling. Clin Chem. 2010;56:1320-8 pubmed publisher
Bae M, Bissonette G, Mars W, Michalopoulos G, Achim C, Depireux D, et al. Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility. Exp Neurol. 2010;221:129-35 pubmed publisher
Coxon A, Rex K, Meyer S, Sun J, Sun J, Chen Q, et al. Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte growth factor: c-Met-dependent tumors in animal models. Mol Cancer Ther. 2009;8:1119-25 pubmed publisher
Marsh D, Dickinson S, Neill G, Marshall J, Hart I, Thomas G. alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation. Cancer Res. 2008;68:3295-303 pubmed publisher
Hatfield K, Ryningen A, Corbascio M, Bruserud O. Microvascular endothelial cells increase proliferation and inhibit apoptosis of native human acute myelogenous leukemia blasts. Int J Cancer. 2006;119:2313-21 pubmed
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, et al. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol. 2005;175:6177-89 pubmed
Barbour A, Reeder J, Walsh M, Fawcett J, Antalis T, Gotley D. Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3. Cancer Res. 2003;63:887-92 pubmed
Takayama K, Suzuki J, Kawauchi M, Tsukioka K, Wada Y, Zhang T, et al. Hepatocyte growth factor and vascular endothelial growth factor expression in pig-to-primate xenotransplanted hearts. Transplant Proc. 2000;32:987-9 pubmed

product information

master code :

MAB294

SKU :

MAB294-100

product name :

Human HGF Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human HGF Antibody from R&D Systems is a mouse monoclonal antibody to HGF. This antibody reacts with human,porcine. The Human HGF Antibody has been validated for the following applications: Western Blot,Bioassay,Luminex Development,Flow Cytometry,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,Immunohistochemistry.

target :

HGF

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

24612

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human HGF, Gln32-Ser728 (Asp384Asn, Asp416Asn, Leu622Ser, His645Arg, Val678Ile), Accession # P14210

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Porcine

specificity :

Detects human HGF in Western blots. In Western blots, no-cross reactivity with recombinant mouse HGF or recombinant canine HGF is observed.

gene symbol :

HGF

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Recombinant Human, Mouse, and Canine HGF antibody by Western Blot.

accessionNumbers :

P14210

applications :

Western Blot,Bioassay,Luminex Development,Flow Cytometry,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,Immunohistochemistry

USD :

489 USD

alt names :

deafness, autosomal recessive 39, DFNB39, EC 3.4.21, EC 3.4.21.7, fibroblast-derived tumor cytotoxic factor, F-TCF, hepatocyte growth factor (hepapoietin A; scatter factor), Hepatopoeitin-A, Hepatopoietin A, HGFB, HPTA, HPTAhepatocyte growth factor, lung fibroblast-derived mitogen, Scatter factor, SF, SFhepatopoeitin-A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage