BMP-10 Antibody | R&D Systems MAB2926-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

BMP-10 Antibody

catalog :

MAB2926-100

quantity :

100 ug (also 500 ug, 25 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

462732

reactivity :

human, mouse

application :

western blot, neutralization

more info or order :

R&D Systems product webpage

citations: 7

Reference
Guo J, Liu B, Thorikay M, Yu M, Li X, Tong Z, et al. Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun. 2022;13:2395 pubmed publisher
Owen N, Alexander G, Sen S, Bunclark K, Polwarth G, Pepke Zaba J, et al. Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis. EBioMedicine. 2020;56:102794 pubmed publisher
Tillet E, Ouarné M, Desroches Castan A, Mallet C, Subileau M, Didier R, et al. A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma. J Biol Chem. 2018;293:10963-10974 pubmed publisher
Ruiz S, Zhao H, Chandakkar P, Chatterjee P, Papoin J, Blanc L, et al. A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10. Sci Rep. 2016;5:37366 pubmed publisher
Levet S, OuarnÃ© M, Ciais D, Coutton C, Subileau M, Mallet C, et al. BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A. 2015;112:E3207-15 pubmed publisher
Ricard N, Ciais D, Levet S, Subileau M, Mallet C, Zimmers T, et al. BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood. 2012;119:6162-71 pubmed publisher
Kahr P, Piccini I, Fabritz L, Greber B, SchÃ¶ler H, Scheld H, et al. Systematic analysis of gene expression differences between left and right atria in different mouse strains and in human atrial tissue. PLoS ONE. 2011;6:e26389 pubmed publisher

image

image 1 :

Alkaline Phosphatase Production Induced by BMP-10 and Neutralization by Human BMP-10 Antibody.

product information

brand :

R&D Systems

MasterCode :

MAB2926

SKU :

MAB2926-100

product name :

BMP-10 Antibody

Description :

The BMP-10 Antibody from MAB2926-100 is a mab2926 antibody to . The BMP-10 Antibody has been validated for the following applications: O95393.

target :

BMP-10

category :

Primary Antibodies

unit size :

100 ug (also 500 ug, 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

462732

conjugate :

Unconjugated

host :

Mouse

immunogen :

Chinese hamster ovary cell line CHO-derived recombinant human BMP-10, Asn317-Arg424, Accession # O95393

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human, Mouse

specificity :

Detects human BMP-10 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) BMP-1.1, 2, 3, 3b, 4, 5, 6, 7, 9, 15, or the pro region of rhBMP-10 is observed. In direct ELISAs, approximately 90% cross-reactivity with recombinant mouse BMP-10 is observed.

gene symbol :

BMP10

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

accessionNumbers :

O95393

applications :

Western Blot, Neutralization

USD :

469 USD

alt names :

BMP10, BMP-10, bone morphogenetic protein 10, MGC126783

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage