product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human IGF-II/IGF2 Antibody
catalog :
MAB292-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
75015
reactivity :
human, mouse
application :
neutralization
more info or order :
R&D Systems product webpage
citations: 8
Reference
Kano F, Hashimoto N, Liu Y, Xia L, Nishihara T, Oki W, et al. Therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for radiation-induced mouse xerostomia. Sci Rep. 2023;13:2706 pubmed publisher
De Giovanni C, Nanni P, Landuzzi L, Ianzano M, Nicoletti G, Croci S, et al. Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis. BMC Cancer. 2019;19:126 pubmed publisher
Guan S, Lam A, Newman J, Chua K, Kok C, Chong S, et al. Matrix metalloproteinase-1 facilitates MSC migration via cleavage of IGF-2/IGFBP2 complex. FEBS Open Bio. 2018;8:15-26 pubmed publisher
Forest A, Amatulli M, Ludwig D, Damoci C, Wang Y, Burns C, et al. Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor. Mol Cancer Res. 2015;13:1615-26 pubmed publisher
Mancini M, Gariboldi M, Taiana E, Bonzi M, Craparotta I, Pagin M, et al. Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. Br J Cancer. 2014;110:2865-73 pubmed publisher
Salisbury T, Morris G, Tomblin J, Chaudhry A, Cook C, Santanam N. Aryl hydrocarbon receptor ligands inhibit igf-ii and adipokine stimulated breast cancer cell proliferation. ISRN Endocrinol. 2013;2013:104850 pubmed publisher
Zhang Y, Jalili F, Ouamara N, Zameer A, Cosentino G, Mayne M, et al. Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: role of IGF-2. J Neuroimmunol. 2010;227:71-9 pubmed publisher
Adkins R, Fain J, Krushkal J, Klauser C, Magann E, Morrison J. Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels. Pediatr Res. 2007;62:451-5 pubmed
product information
master code :
MAB292
SKU :
MAB292-100
product name :
Human IGF-II/IGF2 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human IGF-II/IGF2 Antibody from R&D Systems is a mouse monoclonal antibody to IGF-II/IGF2. This antibody reacts with human,mouse. The Human IGF-II/IGF2 Antibody has been validated for the following applications: ELISA Development,ELISA Standard,Neutralization.
target :
IGF-II/IGF2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
75015
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant human IGF-II/IGF2, Ala25-Glu91, Accession # P01344.1
isotype :
IgG1
purity :
Protein A or G purified from ascites
species :
Human,Mouse
specificity :
Detects human IGF-II/IGF2 in direct ELISA and Western blots. This antibody shows 100% cross-reactivity with recombinant mouse (rm) IGF-II and no cross-reactivity with recombinant human IGF-I or rmIGF-I.
gene symbol :
IGF2
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Cell Proliferation Induced by IGF-II/IGF2 and Neutralization by Human IGF-II/IGF2 Antibody.
accessionNumbers :
P01344.1
applications :
ELISA Development,ELISA Standard,Neutralization
USD :
469 USD
alt names :
C11orf43, chromosome 11 open reading frame 43, FLJ22066, FLJ44734, GRDF, IGF2, IGF-2, IGFII, IGF-II, insulin-like growth factor 2 (somatomedin A), insulin-like growth factor II, insulin-like growth factor type 2, MSA, PEG2, PP9974, somatomedin-A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.