HTRA1/PRSS11 Antibody | R&D Systems MAB2916 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

HTRA1/PRSS11 Antibody

catalog :

MAB2916

quantity :

100 ug (also 25 ug)

price :

449 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

275615

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500; loading ...; fig 5c	Pan Y, Iejima D, Nakayama M, Suga A, Noda T, Kaur I, et al. Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro. J Biol Chem. 2021;296:100456 pubmed publisher
	Kouri A, Caza T, Beck L, Misurac J, Evans M, Phillips C, et al. Clinical and Histopathologic Characteristics of Pediatric Patients With Primary Membranous Nephropathy. Kidney Int Rep. 2023;8:2368-2375 pubmed publisher
	Inoue D, Chew G, Liu B, Michel B, Pangallo J, D Avino A, et al. Spliceosomal disruption of the non-canonical BAF complex in cancer. Nature. 2019;574:432-436 pubmed publisher
	Hondius D, Eigenhuis K, Morrema T, van der Schors R, Van Nierop P, Bugiani M, et al. Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease. Acta Neuropathol Commun. 2018;6:46 pubmed publisher
	Yamawaki S, Naitoh M, Kubota H, Aya R, Katayama Y, Ishiko T, et al. HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development. Int J Mol Sci. 2018;19: pubmed publisher
	Globus O, Evron T, Caspi M, Siman Tov R, Rosin Arbesfeld R. High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling. Sci Rep. 2017;7:17995 pubmed publisher
	Melo E, Oertle P, Trepp C, Meistermann H, Burgoyne T, Sborgi L, et al. HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model. EBioMedicine. 2018;27:258-274 pubmed publisher
	Kumar S, Nakashizuka H, Jones A, Lambert A, Zhao X, Shen M, et al. Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy. Am J Pathol. 2017;187:2841-2857 pubmed publisher
	Ng T, Liang X, Lu F, Liu D, Yam G, Ma L, et al. Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations. Lab Invest. 2017;97:43-52 pubmed publisher
	Ng T, Liang X, Lai T, Ma L, Tam P, Wang J, et al. HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration. Sci Rep. 2016;6:28639 pubmed publisher
	Jo H, Patterson V, Stoessel S, Kuan C, Hoh J. Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease. PLoS ONE. 2014;9:e115362 pubmed publisher
	Kumar S, Berriochoa Z, Ambati B, Fu Y. Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2014;55:3842-50 pubmed publisher
	Jacobo S, DeAngelis M, Kim I, Kazlauskas A. Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. Mol Cell Biol. 2013;33:1976-90 pubmed publisher
	Wang N, Eckert K, Zomorrodi A, Xin P, Pan W, Shearer D, et al. Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways. PLoS ONE. 2012;7:e39446 pubmed publisher
	Mauney J, Olsen B, Volloch V. Matrix remodeling as stem cell recruitment event: a novel in vitro model for homing of human bone marrow stromal cells to the site of injury shows crucial role of extracellular collagen matrix. Matrix Biol. 2010;29:657-63 pubmed publisher

image

image 1 :

Detection of Human HTRA1/PRSS11 antibody by Western Blot.

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

MAB2916

SKU :

MAB2916

product name :

HTRA1/PRSS11 Antibody

description :

The Human HTRA1/PRSS11 Antibody from R&D Systems is a mouse monoclonal antibody to HTRA1/PRSS11. This antibody reacts with human,mouse,rat. The Human HTRA1/PRSS11 Antibody has been validated for the following applications: IHC/IF,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunocytochemistry,ELISA Detection.

target :

HTRA1/PRSS11

unit size :

100 ug (also 25 ug)

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

275615

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human HTRA1/PRSS11, Gln23-Pro480, Accession # Q92743

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human HTRA1/PRSS11 in direct ELISAs and Western blots.

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

gene symbol :

HTRA1

accessionNumbers :

Q92743

applications :

Immunohistochemistry,Immunoprecipitation,Western Blot,Immunocytochemistry,ELISA Detection

product keywords :

MAB2916, hHTRA1 MAb Cl 275615, Mouse Anti-Human HTRA1/PRSS11 Monoclonal Antibody, Anti-HTRA1, Anti-PRSS11, Mouse Anti Human HTRA1/PRSS11 Monoclonal Antibody, Anti-hHTRA1, bioprocessingenzymes, HTRA 1, PRSS 11, Serine Protease, IGF binding

USD :

449

USD 2025 :

449 USD

alt names :

ARMD7, EC 3.4.21, EC 3.4.21.108, High-temperature requirement A serine peptidase 1, HtrA serine peptidase 1, IGFBP5-protease, L56, ORF480, PRSS11, Serine protease 11, serine, 11 (IGF binding)

more info or order :

R&D Systems product webpage