product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Alkaline Phosphatase/ALPL Antibody
catalog :
MAB29091
quantity :
100 ug (also 25 ug)
price :
439 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
388828
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 6
Reference
Zhang Z, Nam H, Crouch S, Hatch N. Tissue Nonspecific Alkaline Phosphatase Function in Bone and Muscle Progenitor Cells: Control of Mitochondrial Respiration and ATP Production. Int J Mol Sci. 2021;22: pubmed publisher
Fu R, Lv W, Xu Y, Gong M, Chen X, Jiang N, et al. Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis. Nat Commun. 2020;11:460 pubmed publisher
Zheng H, Bae Y, Kasimir Bauer S, Tang R, Chen J, Ren G, et al. Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy. Cancer Cell. 2017;32:731-747.e6 pubmed publisher
Onishi K, Tonge P, Nagy A, Zandstra P. Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency. Stem Cell Reports. 2014;3:156-68 pubmed publisher
Foster B, Nagatomo K, Nociti F, Fong H, Dunn D, Tran A, et al. Central role of pyrophosphate in acellular cementum formation. PLoS ONE. 2012;7:e38393 pubmed publisher
Yadav M, de Oliveira R, Foster B, Fong H, Cory E, Narisawa S, et al. Enzyme replacement prevents enamel defects in hypophosphatasia mice. J Bone Miner Res. 2012;27:1722-34 pubmed publisher
product information
master code :
MAB29091
SKU :
MAB29091
product name :
Human Alkaline Phosphatase/ALPL Antibody
unit size :
100 ug (also 25 ug)
description :
The Human Alkaline Phosphatase/ALPL Antibody from R&D Systems is a rat monoclonal antibody to Alkaline Phosphatase/ALPL. This antibody reacts with human,mouse. The Human Alkaline Phosphatase/ALPL Antibody has been validated for the following applications: Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry.
target :
Alkaline Phosphatase/ALPL
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
388828
concentration :
LYOPH
conjugate :
Unconjugated
host :
Rat
immunogen :
E. coli -derived recombinant human Alkaline Phosphatase/ALPL, Leu18-Ser502, Accession # P05186
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
specificity :
Detects human Alkaline Phosphatase/ALPL in direct ELISAs. In direct ELISAs, 80-100% cross-reactivity with recombinant mouse Alkaline Phosphatase/ALPL is observed and no cross-reactivity with recombinant human (rh) Alkaline Phosphatase/ALPP or rhAlkaline Phosphatase/ALPI is observed.
gene symbol :
ALPL
top caption :
Alkaline Phosphatase/ALPL antibody in BG01V Human Embryonic Stem Cells by Immunocytochemistry (ICC).
accessionNumbers :
P05186
applications :
Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry
USD :
439 USD
alt names :
Akp2, Alkaline phosphatase liver/bone/kidney isozyme, alkaline phosphatase, liver/bone/kidney, alkaline phosphatase, tissue-nonspecific isozyme, alkaline phosphomonoesterase, APTNAP, AP-TNAP, EC 3.1.3.1, FLJ40094, FLJ93059, glycerophosphatase, HOPS, liver/bone/kidney-type alkaline phosphatase, MGC161443, tissue-nonspecific ALP, TNAP, TNSALP, TNSALPMGC167935
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.